Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

1996 • 1,201 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

Catechol O -methyltransferase val ¹⁵⁸ -met genotype and individual variation in the brain response to amphetamine

2003 • 900 citations

Implementing a unified approach to family-based tests of association

2000 • 844 citations

Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

2002 • 842 citations

The family based association test method: strategies for studying general genotype–phenotype associations

2001 • 740 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

2002 • 701 citations

A Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission

1999 • 643 citations

Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

1995 • 634 citations

A Test for Linkage and Association in General Pedigrees: The Pedigree Disequilibrium Test

2000 • 532 citations

Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population

1995 • 426 citations

Fluorescence Polarization in Homogeneous Nucleic Acid Analysis

1999 • 400 citations

Genomewide Genetic Linkage Analysis Confirms the Presence of Susceptibility Loci for Schizophrenia, on Chromosomes 1q32.2, 5q33.2, and 8p21-22 and Provides Support for Linkage to Schizophrenia, on Chromosomes 11q23.3-24 and 20q12.1-11.23

2001 • 376 citations

Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

2003 • 368 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

A Haplotype Implicated in Schizophrenia Susceptibility Is Associated with Reduced COMT Expression in Human Brain

2003 • 340 citations

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

1996 • 308 citations

Transmission/Disequilibrium Tests for Extended Marker Haplotypes

1999 • 281 citations

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

1996 • 232 citations

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

1997 • 222 citations

Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families

1996 • 204 citations

Genetic variation in the 22q11 locus and susceptibility to schizophrenia

2002 • 199 citations

A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits

2003 • 186 citations

Seminars in Psychiatric Genetics

1996 • 178 citations

The Roscommon Family Study

1993 • 168 citations

Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity

1999 • 167 citations

A Two-Stage Genome Scan for Schizophrenia Susceptibility Genes in 196 Affected Sibling Pairs

1999 • 144 citations

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

2000 • 142 citations

Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females

2003 • 139 citations

Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes

2002 • 132 citations

Clinical Features of Schizophrenia and Linkage to Chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families

2000 • 125 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

1998 • 94 citations

Linkage analysis of putative schizophrenia gene candidate regions on chromosomes 3p, 5q, 6p, 8p, 20p and 22q in a population-based sampled Finnish family set

1998 • 80 citations

Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan

2001 • 79 citations

Association between Val^108/158 met polymorphism of the COMT gene and schizophrenia

2003 • 75 citations

Eye movement disturbances in schizophrenia and a polymorphism of catechol-O-methyltransferase gene

2002 • 56 citations

Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles

2000 • 49 citations

Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia

2001 • 49 citations

Family‐based and case–control study of catechol‐O‐methyltransferase in schizophrenia among Palestinian Arabs

2003 • 47 citations

Lack of evidence for association between the COMT locus and schizophrenia

1999 • 42 citations

FP-TDI SNP Scoring by Manual and Statistical Procedures: A Study of Error Rates and Types

2003 • 40 citations

The psychopathological phenotype of velo-cardio-facial syndrome

2002 • 37 citations

No evidence for linkage of chromosome 22 markers to schizophrenia in Southern African Bantu-speaking families

1996 • 30 citations