Neuregulin Signaling via ErbB Receptor Assemblies in the Nervous System

Untangling the ErbB signalling network

2001 • 6,623 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

DHAM-BMSC matrix promotes axonal regeneration and functional recovery after spinal cord injury in adult rats.

2009 • 1,710 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

GAP-43: an intrinsic determinant of neuronal development and plasticity

1997 • 1,285 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 • 1,021 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

1997 • 721 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

1999 • 525 citations

Neuregulin and ErbB receptor signaling pathways in the nervous system

2001 • 490 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

1998 • 400 citations

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

1997 • 385 citations

Isoform-specific expression and function of neuregulin

1997 • 384 citations

Neuregulin and erbB Receptors Play a Critical Role in Neuronal Migration

1997 • 381 citations

Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

2000 • 376 citations

GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

1996 • 374 citations

Binding specificities and affinities of egf domains for ErbB receptors

1999 • 370 citations

Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex

1997 • 366 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

Roles of NMDA receptor activity and nitric oxide production in brain development

2000 • 337 citations

Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

1999 • 321 citations

Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

1996 • 311 citations

Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

1999 • 307 citations

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

2000 • 289 citations

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1997 • 288 citations

Basic science of HER-2/neu: a review.

1999 • 267 citations

Nitric oxide stimulates Ca2+-independent synaptic vesicle release

1994 • 263 citations

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

2000 • 261 citations

Neuregulin-β induces expression of an NMDA-receptor subunit

1997 • 261 citations

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

1998 • 259 citations

Identification and purification of glial growth factor

1984 • 243 citations

Nitric Oxide Modulates Synaptic Vesicle Docking/Fusion Reactions

1996 • 238 citations

Cell death in the Schwann cell lineage and its regulation by neuregulin.

1996 • 237 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Protein phosphorylation and the regulation of synaptic membrane traffic

1999 • 236 citations

Neuregulins in Development

1996 • 229 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency

1998 • 208 citations

Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo.

1998 • 206 citations

Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

2000 • 181 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Role of neuregulins in glial cell development

2000 • 175 citations

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS

1995 • 170 citations

Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor

1998 • 170 citations

Failure of spinal cord oligodendrocyte development in mice lacking neuregulin

1999 • 165 citations

Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.

1999 • 160 citations

The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis

1998 • 152 citations

A Novel, Nerve Growth Factor-activated Pathway Involving Nitric Oxide, p53, and p21WAF1 Regulates Neuronal Differentiation of PC12 Cells

1997 • 152 citations

Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination

2001 • 148 citations

Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes.

1994 • 147 citations

Neu Differentiation Factor/Neuregulin Isoforms Activate Distinct Receptor Combinations

1996 • 142 citations

Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation

1997 • 131 citations

Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

1998 • 123 citations

PDZ-dependent Activation of Nitric-oxide Synthases by the Serotonin 2B Receptor

2000 • 122 citations

Neuregulin Signaling Regulates Neural Precursor Growth and the Generation of OligodendrocytesIn Vitro

2001 • 121 citations

Regulation of Neuregulin Expression in the Injured Rat Brain and Cultured Astrocytes

2001 • 112 citations

Signalling through the JAK–STAT pathway in the developing brain

1999 • 111 citations

Neuregulins Signaling via a Glial erbB-2–erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual Development

1999 • 110 citations

Expression of multiple neuregulin transcripts in postnatal rat brains

1994 • 109 citations

The neuron–glia signal β‐neuregulin promotes Schwann cell motility via the MAPK pathway

2001 • 106 citations

Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain

1998 • 105 citations

Induction and variants of neuronal nitric oxide synthase type I during synaptogenesis

1995 • 105 citations

Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma.

1998 • 101 citations

Translational control in vertebrate development

2001 • 98 citations

Ubiquitination of Neuronal Nitric-oxide Synthase in Vitro and in Vivo

2000 • 90 citations

ErbB‐4 Activation Promotes Neurite Outgrowth in PC12 Cells

2000 • 89 citations

Erbin Is a Protein Concentrated at Postsynaptic Membranes That Interacts with PSD-95

2001 • 89 citations

The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins

2001 • 87 citations

Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2

1998 • 87 citations

Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression

1998 • 82 citations

Cultured neonatal schwann cells contain and secrete neuregulins

1996 • 74 citations

A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4

1997 • 72 citations

Expression of the EGF Receptor Family Members ErbB2, ErbB3, and ErbB4 in Germinal Zones of the Developing Brain and in Neurosphere Cultures Containing CNS Stem Cells

2000 • 71 citations

Release of the Neuregulin Functional Polypeptide Requires Its Cytoplasmic Tail

1998 • 61 citations

Both the Neuronal and Inducible Isoforms Contribute to Upregulation of Retinal Nitric Oxide Synthase Activity by Brain-Derived Neurotrophic Factor

1999 • 59 citations

Roles of endogenous nitric oxide in cerebellar cortical development in slice cultures

1994 • 58 citations

Neonatal Oligodendrocytes Contain and Secrete Neuregulins In Vitro

1997 • 54 citations

Localization and modulation of ErbB receptor tyrosine kinases

2001 • 54 citations

Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells

2000 • 48 citations

Neuregulin-1 proteins in rat brain and transfected cells are localized to lipid rafts

2001 • 47 citations

BDNF Increases the Number of Axotomized Rat Retinal Ganglion Cells Expressing GAP-43, L1, and TAG-1 mRNA—A Supportive Role for Nitric Oxide?

2001 • 47 citations

The EGF domain: Requirements for binding to receptors of the ErbB family

2000 • 45 citations

Expression of receptors for neuregulins, ErbB2, ErbB3 and ErbB4, in developing mouse cerebellum

1998 • 41 citations

Neuregulins and erbB receptor expression in adult human oligodendrocytes

2000 • 36 citations

The Effects of NGF and Sensory Nerve Stimulation on Collateral Sprouting and Gene Expression in Adult Sensory Neurons

1998 • 35 citations

GAP-43 (B-50) and C-Jun Are Up-Regulated in Axotomized Neurons of Clarke's Nucleus after Spinal Cord Injury in the Adult Rat

1999 • 32 citations

Neuregulin found in cultured-sciatic nerve conditioned medium causes neuronal differentiation of PC12 cells

2000 • 32 citations

Quantitative analysis of nitric oxide synthase expressed in developing and differentiating rat cerebellum

1998 • 30 citations

Neuregulins and ErbB receptors in cultured neonatal astrocytes

1999 • 20 citations

Heregulin upregulates the expression of nitric oxide synthase (NOS)‐1 in rat cerebellar granule neurons via the ErbB4 receptor

2001 • 16 citations

Regulation of functional nitric oxide synthase‐1 expression in cerebellar granule neurons by heregulin is post‐transcriptional, and involves mitogen‐activated protein kinase

2001 • 15 citations

Neuregulin-Induced Association of Sos Ras Exchange Protein with HER2(erbB2)/HER3(erbB3) Receptor Complexes in Schwann Cells through a Specific Grb2-HER2(erbB2) Interaction

2001 • 14 citations