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The neuropathology of schizophrenia

Data up to Jan 2025

Published1999
Citations1,664
References376
Clinical Trials (1)

Total Citations Per Year

Abstract

References (376)

Dementia Praecox or the Group of Schizophrenias

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Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia

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BRAIN PLASTICITY AND BEHAVIOR

1998 • 718 citations

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

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Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

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Postmortem Evidence of Structural Brain Changes in Schizophrenia

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1992 • 665 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

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1994 • 642 citations

Dopamine D4 receptors elevated in schizophrenia

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From neuropathology to neurodevelopment

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Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

1990 • 558 citations

Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia

1990 • 543 citations

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

1998 • 542 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

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1997 • 517 citations

Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia

1991 • 517 citations

Use-dependent growth of pyramidal neurons after neocortical damage

1994 • 513 citations

5-Hydroxytryptamine 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

1998 • 510 citations

Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

1994 • 507 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

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Cell loss in the hippocampus of schizophrenics

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1982 • 472 citations

A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives

1998 • 468 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Limbic pathology in schizophrenia: The entorhinal region—a morphometric study

1988 • 441 citations

Hippocampal Pathologic Findings in Schizophrenia

1989 • 437 citations

Frontal-striatal cognitive deficits in patients with chronic schizophrenia

1997 • 434 citations

Regional Brain Activity in Chronic Schizophrenic Patients during the Performance of a Verbal Fluency Task

1995 • 429 citations

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics

1997 • 419 citations

A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia

1998 • 408 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Obstetric Complications and Schizophrenia: A Meta-Analysis

1995 • 404 citations

Temporal Lobe Asymmetries as the Key to the Etiology of Schizophrenia

1990 • 398 citations

PATHOLOGY OF THE NERVOUS SYSTEM

1949 • 394 citations

Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method

1998 • 394 citations

Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients

1996 • 391 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

Discussion

1997 • 373 citations

Hippocampus in autism: a Golgi analysis

1995 • 373 citations

Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

1992 • 371 citations

Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

1997 • 367 citations

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia

1999 • 362 citations

Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder

1997 • 358 citations

Genetic variability of human brain size and cortical gyral patterns

1997 • 348 citations

Schizophrenia – a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder

1995 • 345 citations

Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders

1998 • 341 citations

Symptoms, signs, and diagnosis of schizophrenia

1995 • 339 citations

Neurochemical Sensitization in the Pathophysiology of Schizophrenia: Deficits and Dysfunction in Neuronal Regulation and Plasticity

1997 • 336 citations

Schizophrenia: A Subcortical Neurotransmitter Imbalance Syndrome?

1990 • 335 citations

Reduction of Synaptophysin Immunoreactivity in the Prefrontal Cortex of Subjects With Schizophrenia

1997 • 334 citations

Causes and Consequences of the Gender Difference in Age at Onset of Schizophrenia

1998 • 331 citations

Neuropsychological functioning of first-episode schizophreniform patients

1992 • 324 citations

Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions

1995 • 319 citations

PET and MRI of the thalamus in never-medicated patients with schizophrenia

1996 • 319 citations

CEREBRAL VENTRICULAR SIZE IN TWINS DISCORDANT FOR SCHIZOPHRENIA

1982 • 313 citations

Psychiatric Disturbances in Metachromatic Leukodystrophy

1992 • 302 citations

The Varied Outcomes of Schizophrenia

1997 • 295 citations

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

1992 • 291 citations

If you assume, you can make an ass out of u and me': a decade of the disector for stereological counting of particles in 3D space.

1996 • 287 citations

Schizophrenia and the brain: a prospective clinico-neuropathological study

1990 • 287 citations

5-HT1A and 5-HT2A Receptor mRNAs and Binding Site Densities Are Differentially Altered in Schizophrenia

1996 • 287 citations

An Analysis of the Arrangement of Neurons in the Cingulate Cortex of Schizophrenic Patients

1987 • 280 citations

Absence of regional hemispheric volume asymmetries in first-episode schizophrenia

1994 • 277 citations

Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients

1991 • 276 citations

Functional Clustering: Identifying Strongly Interactive Brain Regions in Neuroimaging Data

1998 • 273 citations

The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain

1995 • 272 citations

Amnesic syndrome in schizophrenia

1990 • 270 citations

Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

1996 • 263 citations

Structural abnormalities in deficit and nondeficit schizophrenia

1993 • 260 citations

Cortical Pruning and the Development of Schizophrenia: A Computer Model

1989 • 259 citations

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response

1998 • 254 citations

The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system

1993 • 251 citations

Quantitative Brain Measurements in Chronic Schizophrenia

1972 • 251 citations

Childhood-Onset Schizophrenia

1997 • 250 citations

Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia

1995 • 248 citations

The genetic basis for schizophrenia

1973 • 247 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging.

1990 • 245 citations

Hippocampal Pyramidal Cell Disarray in Schizophrenia as a Bilateral Phenomenon

1991 • 239 citations

Mesolimbic Dopamine D3 Receptors and Use of Antipsychotics in Patients With Schizophrenia

1997 • 236 citations

The neuropsychological signature of schizophrenia: generalized or differential deficit?

1994 • 235 citations

Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors

1997 • 235 citations

Schizophrenia: A disease of heteromodal association cortex?

1996 • 234 citations

Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.

1991 • 234 citations

Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients

1992 • 225 citations

Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics

1990 • 224 citations

Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics

1998 • 224 citations

SCHIZOPHRENIA AND THE LIMBIC SYSTEM

1974 • 223 citations

Cortical Development and Thalamic Pathology in Schizophrenia

1997 • 223 citations

The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study

1999 • 220 citations

Anomalous Cerebral Asymmetry and Language Processing in Schizophrenia

1997 • 218 citations

Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia

1995 • 216 citations

The role of serotonin in the pathophysiology and treatment of schizophrenia

1997 • 214 citations

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia

1995 • 213 citations

Hippocampal Pyramidal Cell Orientation in Schizophrenia

1987 • 210 citations

Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia

1996 • 210 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers

1993 • 208 citations

Recent advances in defining the neuropathology of schizophrenia

1996 • 206 citations

Schizophrenia: A Neuropathological Perspective

1991 • 206 citations

Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities

1997 • 205 citations

Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia

1997 • 204 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study

1998 • 203 citations

Post-mortem Study of Chronic Schizophrenic Brains

1987 • 203 citations

Advancing a Neurodevelopmental Origin for Schizophrenia

1993 • 202 citations

The Human Entorhinal Cortex: A Cytoarchitectonic Analysis

2017 • 202 citations

The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics

1992 • 202 citations

Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia

1998 • 200 citations

Brain Anatomic Magnetic Resonance Imaging in Childhood-Onset Schizophrenia

1996 • 198 citations

Decreased Caudate Volume in Neuroleptic-Naive Psychotic Patients

1998 • 198 citations

Reduced GABA uptake sites in the temporal lobe in schizophrenia

1989 • 198 citations

A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics.

1983 • 197 citations

Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography

1995 • 195 citations

Schizophrenia and anteroventral thalamic nucleus: selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons

1998 • 193 citations

Hippocampal Neuron Number in Schizophrenia

1991 • 188 citations

Course of Schizophrenia: Neuropsychological Evidence for a Static Encephalopathy

1993 • 187 citations

The Hippocampus and Parahippocampus in Schizophrenic, Suicide, and Control Brains

1990 • 187 citations

Progressive Reduction of Temporal Lobe Structures in Childhood-Onset Schizophrenia

1998 • 186 citations

Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons

1995 • 186 citations

Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia

1995 • 183 citations

Meta-analysis of brain and cranial size in schizophrenia

1996 • 183 citations

霊長類大脳皮質の5‐ヒドロキシトリプタミン2Aセロトニン受容体 錐体細胞先端樹状突起での幻覚剤及び抗精神病剤の作用部位

1998 • 183 citations

The Neuroanatomy of Alzheimer's Disease

1989 • 181 citations

Layer‐specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex

1998 • 179 citations

Ventricular Enlargement in Schizophrenia

1992 • 178 citations

A Quantitative Investigation of Hippocampal Pyramidal Cell Size, Shape, and Variability of Orientation in Schizophrenia

1989 • 177 citations

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

1997 • 176 citations

Alzheimer Disease and Related Neurodegenerative Diseases in Elderly Patients With Schizophrenia

1998 • 174 citations

[3H]WAY–100635 for 5–HT1A receptor autoradiography in human brain: a comparison with [3H]8–OH–DPAT and demonstration of increased binding in the frontal cortex in schizophrenia

1997 • 174 citations

SNAP-25 deficit and hippocampal connectivity in schizophrenia

1998 • 172 citations

Neuropathology of Schizophrenia: Cortex, Thalamus, Basal Ganglia, and Neurotransmitter-specific Projection Systems

1997 • 172 citations

Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics

1997 • 171 citations

Schizophrenia-like psychoses associated with organic cerebral disorders: a review.

1983 • 171 citations

NEUROPATHOLOGICAL INVESTIGATION OF 28 BRAINS FROM PATIENTS WITH DYSKINESIA

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Volumetric Evaluation of the Thalamus in Schizophrenic Male Patients Using Magnetic Resonance Imaging

1998 • 168 citations

Morphological variation of layer III pyramidal neurones in the occipitotemporal pathway of the macaque monkey visual cortex

1998 • 167 citations

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1994 • 160 citations

Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study

1995 • 159 citations

The Neuropsychology of Schizophrenia

2019 • 158 citations

Dorsal Striatal Size, Shape, and Metabolic Rate in Never-Medicated and Previously Medicated Schizophrenics Performing a Verbal Learning Task

1998 • 158 citations

Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia

1997 • 158 citations

Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics

1993 • 157 citations

Schizophrenia as a developmental disorder of the cerebral cortex

1998 • 156 citations

Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine

1998 • 156 citations

An ultrastructural size principle

1994 • 155 citations

Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia

1998 • 155 citations

Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study

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Sex Differences in Brain Morphology in Schizophrenia

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Is there gliosis in schizophrenia? Investigation of the temporal lobe

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MRI Study of Cavum Septi Pellucidi in Schizophrenia, Affective Disorder, and Schizotypal Personality Disorder

1998 • 153 citations

Schizophrenia and the myth of intellectual decline

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Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?

1997 • 152 citations

Cerebral Gray Matter Volume Deficits in First Episode Psychosis

1998 • 151 citations

Gliosis in schizophrenia: A survey

1986 • 150 citations

Loss of sylvian fissure asymmetry in schizophrenia

1992 • 148 citations

Clinical subtypes of schizophrenia: differences in brain and CSF volume

1994 • 148 citations

Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia

1997 • 146 citations

No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone

1995 • 146 citations

Schizophrenia as a transcallosal misconnection syndrome

1998 • 145 citations

Multivariate analysis of RNA levels from postmortem human brains as measured by three different methods of RT-PCR

1997 • 144 citations

Increased Vertical Axon Numbers in Cingulate Cortex of Schizophrenics

1987 • 142 citations

Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness

1994 • 141 citations

The Role of Synaptic Proteins in the Pathogenesis of Disorders of the Central Nervous System

1993 • 140 citations

Structural brain abnormalities in male schizophrenics reflect fronto-temporal dissociation

1997 • 138 citations

On the possible role of neocortex and its limbic connections in the process of attention and schizophrenia: Clinical cases of inattention in man and experimental anatomy in monkey

1978 • 138 citations

Abnormal Reinnervation as a Basis for Schizophrenia: A Hypothesis

1992 • 137 citations

‘Pfropfschizophrenie’ revisited

1998 • 137 citations

Schizophrenia: a disorder of neurodevelopment?

1997 • 134 citations

Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats.

1995 • 132 citations

ON THE WEIGHT OF THE BRAIN AND ITS COMPONENT PARTS IN THE INSANE

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Limbic Structures and Lateral Ventricle in Schizophrenia

1990 • 130 citations

Further Evidence of Abnormal Cytoarchitecture of the Entorhinal Cortex in Schizophrenia Using Spatial Point Pattern Analyses

1997 • 130 citations

Increased Density of Glutamate-immunoreactive Vertical Processes in Superficial Laminae in Cingulate Cortex of Schizophrenic Brain

1992 • 129 citations

Epilepsy, psychosis, and schizophrenia

1994 • 127 citations

Schizophrenia and Related Syndromes

2013 • 127 citations

Increased Concentrations of Presynaptic Proteins in the Cingulate Cortex of Subjects With Schizophrenia

1997 • 127 citations

Model Generation and Testing to Probe Neural Circuitry in the Cingulate Cortex of Postmortem Schizophrenic Brain

1998 • 126 citations

Morphological study of neocortical areas in Rett syndrome

1997 • 126 citations

Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects

1996 • 124 citations

Age and hemisphere effects on dendritic structure

1996 • 123 citations

Problem of diagnosis in postmortem brain studies of schizophrenia

1996 • 120 citations

Dopamine D2 densities and the schizophrenic brain

1998 • 119 citations

Regional neuropathology in schizophrenia: Where are we? Where are we going?

1993 • 119 citations

Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996 • 118 citations

Progression of cerebroventricular enlargement and the subtyping of schizophrenia

1997 • 118 citations

Natural Variation in Neuron Number in Mice Is Linked to a Major Quantitative Trait Locus on Chr 11

1998 • 118 citations

ON THE WEIGHT OF THE BRAIN AND ITS COMPONENT PARTS IN THE INSANE

1879 • 117 citations

Cognitive functioning in late-life schizophrenia: a comparison of elderly schizophrenic patients and patients with Alzheimer's disease

1996 • 117 citations

Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia

1996 • 116 citations

Linking the Family of D2 Receptors to Neuronal Circuits in Human Brain: Insights into Schizophrenia

1997 • 116 citations

The Brain Stem in Psychosis

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Schizophrenia: Recent Epidemiologic Issues

1995 • 113 citations

Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients

1995 • 112 citations

Lack of a bimodal distribution of ventricular size in schizophrenia: A Gaussian mixture analysis of 1056 cases and controls

1991 • 109 citations

Chemical brain anatomy in schizophrenia

1995 • 108 citations

Postmortem Studies of the Hippocampal Formation in Schizophrenia

1997 • 108 citations

Mesopontine neurons in schizophrenia

1995 • 107 citations

Does dysplasia cause anatomical dysconnectivity in schizophrenia?

1998 • 106 citations

Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia

1995 • 104 citations

Reduced Purkinje Cell Size in the Cerebellar Vermis of Elderly Patients With Schizophrenia

1998 • 102 citations

Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study

1994 • 101 citations

A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia

1997 • 101 citations

Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia

1997 • 100 citations

Cognitive Impairment in Adolescents With Schizophrenia

1997 • 100 citations

Brain changes in schizophrenia

1998 • 99 citations

MENTAL ILLNESS AND THE AGEING BRAIN

1963 • 98 citations

Locus ceruleus morphometry in aging and schizophrenia

1988 • 98 citations

Gender and schizophrenia.

1997 • 97 citations

A histological study of the corpus callosum in chronic schizophrenia

1983 • 96 citations

Gross and Histological Criteria for Developmental Disorders in Brains of Schizophrenics

1989 • 96 citations

Structural Magnetic Resonance Imaging Abnormalities in Men With Severe Chronic Schizophrenia and an Early Age at Clinical Onset

1997 • 94 citations

Cytoarchitecture of the entorhinal cortex in schizophrenia

1997 • 94 citations

Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study

1994 • 93 citations

Neuropathology of the cerebellum in schizophrenia—An update: 1996 and future directions

1997 • 92 citations

ON THE TOPOGRAPHICAL DISTRIBUTION OF CORTEX LESIONS AND ANOMALIES IN DEMENTIA PRÆCOX, WITH SOME ACCOUNT OF THEIR FUNCTIONAL SIGNIFICANCE

1915 • 92 citations

Heterogeneity of layer II neurons in human entorhinal cortex

1992 • 91 citations

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

1995 • 90 citations

The heterogeneous course of schizophrenia

1997 • 89 citations

Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy

1998 • 88 citations

Schizophrenia.

1996 • 88 citations

The entorhinal cortex: an examination of cyto- and myeloarchitectonic organization in humans

1997 • 86 citations

The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions

1995 • 86 citations

Decreased left frontal lobe N-acetylaspartate in schizophrenia

1997 • 83 citations

Reduced striatal spine size in schizophrenia

1996 • 83 citations

Distribution of Heterotopic Neurons in Normal Hemispheric White Matter: A Morphometric Analysis

1996 • 82 citations

A two-process theory of schizophrenia: Evidence from studies in post-mortem brain

1997 • 82 citations

Prospects for research on schizophrenia. 3. Neurophysiology. Neuropathological findings.

1972 • 81 citations

Differential distribution of tyrosine hydroxylase fibers on small and large neurons in layer II of anterior cingulate cortex of schizophrenic brain

1997 • 80 citations

Cognitive dysfunction in chronic schizophrenia followed prospectively over 10 years and its longitudinal relationship to the emergence of tardive dyskinesia

1996 • 80 citations

No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET

1998 • 80 citations

Schizophrenia, abnormal connection, and brain evolution

1983 • 80 citations

Pathological reaction of astrocytes in perinatal brain injury

1986 • 79 citations

Electron microscopic study on schizophrenia

1972 • 79 citations

The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry

1997 • 77 citations

Cortical gyral anatomy and gross brain dimensions in monozygotic twins discordant for schizophrenia

1996 • 75 citations

Pre-clinical Pharmacology of Atypical Antipsychotic Drugs: A Selective Review

1996 • 74 citations

Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia

1998 • 73 citations

Alzheimer-type Neuropathology in Elderly Schizophrenia Patients

1993 • 73 citations

In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy

1998 • 73 citations

The occurrence of organic disease of possible or probable aetiological significance in a population of 268 cases of first episode schizophrenia

1987 • 71 citations

Cortical cholinergic markers in schizophrenia

1994 • 69 citations

Altered distribution of parvalbumin-immunoreactive local circuit neurons in the anterior cingulate cortex of schizophrenic patients

1997 • 67 citations

Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes

1997 • 66 citations

Quantitative study of gliosis in schizophrenia and huntington's chorea

1988 • 66 citations

The role of gender in studies of ventricle enlargement in schizophrenia: a predominantly male effect

1990 • 65 citations

Chapter 12 Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease

1986 • 64 citations

The Effect of Chronic Haloperidol Treatment on Dendritic Spines in the Rat Striatum

1997 • 64 citations

The human striatum in schizophrenia. II. Increased number of striatal neurons in schizophrenics

1997 • 64 citations

Anomalies of cerebral asymmetry in schizophrenia interact with gender and age of onset: a post-mortem study

1998 • 62 citations

Similar extent of brain dysmorphology in severely ill women and men with schizophrenia

1997 • 61 citations

Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia

1996 • 61 citations

Cognitive impairment as a target for pharmacological treatment in schizophrenia

1995 • 60 citations

Neural Plasticity in Schizophrenia

1985 • 60 citations

Genetically‐associated variations in the development of hippocampal pyramidal neurons may produce differences in mossy fiber connectivity

1977 • 60 citations

Lesions of the Nucleus Ansae Peduncularis in Neuropsychiatric Disease

1981 • 60 citations

Hippocampal volume reduction in male schizophrenic patients

1998 • 59 citations

Correlational Patterns of Cerebral Glucose Metabolism in Never-Medicated Schizophrenics

1996 • 58 citations

The early origins of schizophrenia

1997 • 58 citations

A Candidate Molecule Approach to Defining Developmental Pathology in Schizophrenia

1998 • 57 citations

Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia

1998 • 57 citations

Magnopyramidal Neurons in the Anterior Motor Speech Region

1996 • 57 citations

Total number of neurons in the layers of the human entorhinal cortex

1998 • 56 citations

Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 55 citations

Lateral ventricular enlargement in schizophrenic probands and their siblings with schizophrenia-related isorders

1998 • 55 citations

Pneumoencephalographic evidence of brain atrophy in acute and chronic schizophrenic patients

1982 • 55 citations

Neuronal Misconnections and Psychiatric Disorder

1989 • 54 citations

In this issue ofThe American Journal of Psychiatry

1996 • 54 citations

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The neuropathology of schizophrenia (1999) – Brain | Metascience Observatory Explorer