Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

2000 • 907 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

1998 • 870 citations

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

1995 • 847 citations

The Enteric Nervous System

1996 • 756 citations

A BDNF autocrine loop in adult sensory neurons prevents cell death

1995 • 743 citations

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

1997 • 721 citations

Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture

1980 • 672 citations

Axonal Self-Destruction and Neurodegeneration

2002 • 632 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns

1987 • 503 citations

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

1987 • 490 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 467 citations

The TrkB-Shc Site Signals Neuronal Survival and Local Axon Growth via MEK and PI3-Kinase

2000 • 431 citations

GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

1996 • 374 citations

The Relationship between Neuronal Survival and Regeneration

2000 • 342 citations

Induction of sodium channel clustering by oligodendrocytes

1997 • 328 citations

Role of neurotrophic factors in neuronal development

1996 • 294 citations

Depolarization and Neurotrophins Converge on the Phosphatidylinositol 3-Kinase–Akt Pathway to Synergistically Regulate Neuronal Survival

1999 • 253 citations

Oligodendroglia Regulate the Regional Expansion of Axon Caliber and Local Accumulation of Neurofilaments during Development Independently of Myelin Formation

1996 • 247 citations

Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases

2000 • 244 citations

Oligodendrocytes as providers of growth factors

2002 • 241 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton

1999 • 198 citations

Neuroprotection Mediated by Glial Cell Line-Derived Neurotrophic Factor: Involvement of a Reduction of NMDA-Induced Calcium Influx by the Mitogen-Activated Protein Kinase Pathway

2001 • 189 citations

A role for oligodendrocyte‐derived IGF‐1 in trophic support of cortical neurons

2001 • 183 citations

c-Src Is Required for Glial Cell Line-Derived Neurotrophic Factor (GDNF) Family Ligand-Mediated Neuronal Survival via a Phosphatidylinositol-3 Kinase (PI-3K)-Dependent Pathway

2001 • 171 citations

Programmed cell death and the control of cell survival

1994 • 169 citations

Other neurotrophic factors: Glial cell line-derived neurotrophic factor (GDNF)

1999 • 163 citations

Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo.

2001 • 159 citations

Local Control of Neurofilament Accumulation during Radial Growth of Myelinating Axons in Vivo

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Even in culture, oligodendrocytes myelinate solely axons.

1993 • 125 citations

Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1)

1998 • 122 citations

p21 Ras and Phosphatidylinositol-3 Kinase Are Required for Survival of Wild-Type and NF1 Mutant Sensory Neurons

1998 • 121 citations

The role of oligodendrocytes and myelin on axon maturation in the developing rat retinofugal pathway

1994 • 112 citations

Murine oligodendroglial cells express nerve growth factor.

1994 • 78 citations

Apoptotic Cell Death of Cultured Cerebral Cortical Neurons Induced by Withdrawal of Astroglial Trophic Support

1998 • 67 citations

GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development

1999 • 52 citations

Calcium influx and membrane depolarization induce phosphorylation of neurofilament (NF-M) KSP repeats in PC12 cells

1999 • 25 citations