Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia

Comprehensive Textbook of Psychiatry

1967 • 3,952 citations

Multiple receptors for dopamine

1979 • 3,739 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

From motivation to action: Functional interface between the limbic system and the motor system

1980 • 2,292 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Chemical Neuroanatomy

1984 • 1,646 citations

Comprehensive Textbook of Psychiatry

1994 • 1,370 citations

The organization of the projection from the cerebral cortex to the striatum in the rat

1989 • 1,334 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.

1979 • 1,184 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

1984 • 866 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

The role of dopamine in locomotor activity and learning

1983 • 849 citations

The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems

1984 • 815 citations

How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements

1978 • 735 citations

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

1989 • 734 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA

1974 • 673 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Microdialysis—Theory and application

1990 • 651 citations

On the Presence of 3-Hydroxytyramine in Brain

1958 • 632 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

1966 • 496 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum

1984 • 467 citations

MECHANISM OF THE ANTIPSYCHOTIC EFFECT IN THE TREATMENT OF ACUTE SCHIZOPHRENIA

1978 • 464 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system

1989 • 435 citations

Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons

1989 • 434 citations

Amphetamine Psychosis

1957 • 429 citations

Catecholamines in the Brain as Mediators of Amphetamine Psychosis

1972 • 428 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Modulatory actions of norepinephrine in the central nervous system.

1979 • 421 citations

Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey

1986 • 382 citations

The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique

1976 • 374 citations

A Quantitative Study on the Nigro‐Neostriatal Dopamine Neuron System in the Rat

1966 • 374 citations

Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia

1985 • 373 citations

Differential effects of amphetamine and neuroleptics on negative Vs. positive symptoms in schizophrenia

1980 • 347 citations

Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum

1981 • 332 citations

Dopamine neurons of the monkey midbrain: contingencies of responses to stimuli eliciting immediate behavioral reactions

1990 • 326 citations

Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients

1986 • 318 citations

Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis

1985 • 314 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat.

1989 • 270 citations

An In Vivo Study of Dopamine Release and Metabolism in Rat Brain Regions Using Intracerebral Dialysis

1986 • 261 citations

Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis

1984 • 247 citations

Neuroleptic-Induced Decrease in Plasma Homovanillic Acid and Antipsychotic Activity in Schizophrenic Patients

1984 • 244 citations

Hippocampal Pyramidal Cell Disarray in Schizophrenia as a Bilateral Phenomenon

1991 • 239 citations

Schizophrenic Symptoms Improve with Apomorphine

1978 • 228 citations

Interaction of norepinephrine with cerebellar activity evoked by mossy and climbing fibers

1977 • 225 citations

Connections of the nucleus accumbens

1976 • 223 citations

Biological Psychiatry

1986 • 218 citations

Quantification of the dopamine innervation in adult rat neostriatum

1986 • 216 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine

1982 • 211 citations

Release of dopamine evoked by electrical stimulation of the motor and visual areas of the cerebral cortex in both caudate nuclei and in the substantia nigra in the cat

1978 • 202 citations

Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: Evidence for its mediation by quisqualateor kainate-receptors

1985 • 201 citations

Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons

1985 • 196 citations

Activation of dopamine receptors inhibits calcium-dependent glutamate release from cotico-striatal terminals in vitro

1980 • 189 citations

The role of dopamine in intracranial self-stimulation of the ventral tegmental area

1987 • 189 citations

Imaging of Neurotransmitter Receptors in the Living Human Brain

1986 • 182 citations

Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat

1981 • 170 citations

Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs

1980 • 169 citations

Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy

1986 • 159 citations

Detecting behaviorally relevant changes in extracellular dopamine with microdialysis

1987 • 150 citations

Real-time measurement of dopamine release in rat brain

1986 • 148 citations

The Effect of Neuroleptics and Other Psychotropic Drugs on Negative Symptoms in Schizophrenia

1986 • 143 citations

Monitoring the Stimulated Release of Dopamine with In Vivo Voltammetry. I: Characterization of the Response Observed in the Caudate Nucleus of the Rat

1984 • 143 citations

[The tropical localization and content of noradrenalin and dopamine (3-hydroxytyramine) in the substantia nigra of normal persons and patients with Parkinson's disease].

1963 • 143 citations

Stimulation of D2-dopamine receptors in rat neostriatum inhibits the release of acetylcholine and dopamine but does not affect the release of γ-aminobutyric acid, glutamate or serotonin

1982 • 142 citations

Differentiation of Dopamine Overflow and Uptake Processes in the Extracellular Fluid of the Rat Caudate Nucleus with Fast-Scan In Vivo Voltammetry

1988 • 129 citations

Amino Acids in Rat Striatal Dialysates: Methodological Aspects and Changes After Electroconvulsive Shock

1985 • 126 citations

Comparative Psychotomimetic Effects of Stereoisomers of Amphetamine

1971 • 125 citations

Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy

1983 • 125 citations

The effect of surgical lesions to frontal cortex and substantia nigra on amphetamine responses in rats

1971 • 123 citations

Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: Correlations to symptomatology and family history

1985 • 121 citations

Supersensitivity in rat caudate nucleus: Effects of 6-hydroxydopamine on the time course of dopamine receptor and cyclic AMP changes

1980 • 113 citations

The effect of l-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs

1975 • 111 citations

Effects of nucleus accumbens amphetamine on lateral hypothalamic brain stimulation reward

1988 • 109 citations

Controversies in Schizophrenia: Changes and Constancies

1986 • 109 citations

Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology

1985 • 101 citations

Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo

1987 • 99 citations

Compensatory responses to nigrostriatal bundle injury

1989 • 95 citations

Monitoring the Stimulated Release of Dopamine with In Vivo Voltammetry. II: Clearance of Released Dopamine from Extracellular Fluid

1984 • 95 citations

Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

1989 • 91 citations

Effects of electrical stimulation of brain reward sites on release of dopamine in rat: An in vivo electrochemical study

1988 • 83 citations

Presynaptic regulation of dopaminergic transmission in the striatum

1988 • 81 citations

Preliminary Evidence of Reduced Combined Output of Dopamine and Its Metabolites in Chronic Schizophrenia

1987 • 79 citations

Notes from the graveyard: neuropathology and schizophrenia*

1990 • 77 citations

Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.

1991 • 69 citations

Do endogenous excitatory amino acids influence striatal dopamine release?

1991 • 69 citations

Potentiation of behavioral arousal after cortical damage and subsequent recovery

1969 • 68 citations

Chronic haloperidol decreases dopamine release in striatum and nucleus accumbens in vivo: Depolarization block as a possible mechanism of action

1987 • 66 citations

Functional Properties of Presumed Doparmine-Containing and Other Ventral Tegmental Area Neurons in Conscious Rats

1988 • 60 citations

Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

1990 • 60 citations

Sertindole, a new neuroleptic with extreme selectivity on A10 versus A9 dopamine neurones in the rat

1990 • 59 citations

Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats

1988 • 58 citations

The effect of L-dopa on young patients with simple schizophrenia reated with neuroleptic subjects.

1975 • 55 citations

γ‐Aminobutyric Acid Can Both Inhibit and Facilitate Dopamine Release in the Caudate Nucleus of the Rabbit

1982 • 54 citations

Effects of ICI 169,369, a selective serotonin2 antagonist, in electrophysiological tests predictive of antipsychotic activity.

1989 • 54 citations

Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons

1992 • 54 citations

Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences

1987 • 51 citations

The dopamine hypothesis: variations on a theme (II).

1986 • 51 citations

Stereoisomers of apomorphine differ in affinity and intrinsic activity at presynaptic dopamine receptors modulating [3H]dopamine and [3H]acetylcholine release in slices of cat caudate

1983 • 51 citations

Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block

1991 • 49 citations

The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: A microdialysis study

1989 • 48 citations

Changes in sensitivity to amphetamine in rats with chronic brain lesions.

1961 • 45 citations

Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions

1989 • 41 citations

Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats

1990 • 40 citations

Behavioral evidence for midbrain dopamine depolarization inactivation

1989 • 39 citations

The effect of l-DOPA on in vivo dopamine release from nigrostriatal bundle neurons

1988 • 36 citations

Clinical Implications of Receptor Sensitivity Modification

1983 • 35 citations

Paradoxical reaction to L-dopa in schizophrenic patients

1978 • 32 citations

GABA in the thalamic motor nuclei modulates dopamine release from the two dopaminergic nigrostriatal pathways in the cat

1983 • 31 citations

NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens

1989 • 31 citations

Activity of neurons in the ventral tegmental region of the behaving monkey

1983 • 29 citations

Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment

1980 • 27 citations

Enhanced dopamine receptor activation in accumbens and frontal cortex has opposite effects on medial forebrain bundle self-stimulation

1990 • 26 citations

A quantitative description of excitatory amino acid neurotransmitter responses on cultured embryonic Xenopus spinal neurons

1989 • 24 citations

Tolerance to haloperidol-induced increases in dopamine metabolites: fact or artifact?

1987 • 21 citations

Spontaneous activity of A9 and A10 dopamine neurons after acute and chronic administration of the selective dopamine D-1 receptor antagonist SCH 23390

1988 • 20 citations

Chronic treatment with high doses of haloperidol fails to decrease the time course for the development of depolarization inactivation of midbrain dopamine neurons

1988 • 16 citations

CI-943, a potential antipsychotic agent. III. Evaluation of effects on dopamine neuronal activity.

1989 • 11 citations

Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats.

1991 • 10 citations

Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats.

1991 • 9 citations

31P NMR studies in schizophrenia

1989 • 9 citations

EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY

1979 • 6 citations