Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

1999 • 1,029 citations

Increased baseline occupancy of D ₂ receptors by dopamine in schizophrenia

2000 • 996 citations

Schizophrenics Show Spatial Working Memory Deficits

1992 • 953 citations

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

2000 • 872 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited

2000 • 811 citations

Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort

1998 • 786 citations

Prefrontal Dopamine D₁Receptors and Working Memory in Schizophrenia

2002 • 724 citations

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

1997 • 707 citations

Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression

1996 • 673 citations

The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task

1994 • 663 citations

Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines

2002 • 661 citations

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

2002 • 640 citations

Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia

2001 • 616 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1988 • 602 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons

2001 • 539 citations

Gating of information flow within the limbic system and the pathophysiology of schizophrenia

2000 • 522 citations

Bidirectional Dopamine Modulation of GABAergic Inhibition in Prefrontal Cortical Pyramidal Neurons

2001 • 511 citations

6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine

1994 • 420 citations

Functional Hypofrontality and Working Memory Dysfunction in Schizophrenia

1998 • 403 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

1999 • 385 citations

Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia

1985 • 373 citations

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

1999 • 371 citations

Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization

2001 • 355 citations

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

2000 • 332 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

1996 • 315 citations

The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia

1991 • 287 citations

Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata

2001 • 280 citations

Localization and Dynamic Regulation of Biogenic Amine Transporters in the Mammalian Central Nervous System

1998 • 276 citations

Atlas of the human brainstem

1995 • 265 citations

Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia

1999 • 243 citations

The Primate Substantia Nigra and VTA: Integrative Circuitry and Function

1997 • 225 citations

A Paradigm Shift in Brain Research

2001 • 220 citations

Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease

1993 • 216 citations

Optimization of cRNA probein situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: A detailed protocol

1990 • 191 citations

Dopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex

2000 • 180 citations

Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice

2002 • 178 citations

New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis

2004 • 177 citations

The Relationship between Dorsolateral Prefrontal Neuronal N-Acetylaspartate and Evoked Release of Striatal Dopamine in Schizophrenia

2000 • 170 citations

The effects of stress on central dopaminergic neurons: possible clinical implications.

1997 • 168 citations

Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons

1994 • 155 citations

Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat

2002 • 147 citations

Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology.

1995 • 145 citations

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

2000 • 142 citations

Cloning, expression and structure of catechol-O-methyltransferase

1995 • 130 citations

Preferential transmission of the high activity allele of COMT in schizophrenia

1996 • 127 citations

Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with parkinson's, alzheimer's with parkinsonism, and alzheimer's disease

1997 • 110 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: Anin vivo neurochemical assessment in the rhesus monkey

1995 • 93 citations

Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area

1997 • 90 citations

Neurocircuitries and neurotransmitter interactions in schizophrenia

1995 • 76 citations

Brain Dopamine Transporter Messenger RNA and Binding Sites in Cocaine Users

1998 • 75 citations

The catecholaminergic innervation of primate prefrontal cortex

1992 • 64 citations

Immunohistochemical study of catechol-O-methyltransferase in the human mesostriatal system

1994 • 56 citations

Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage

1999 • 56 citations

Calbindin D28k-containing neurons are restricted to the medial substantia nigra in humans

1995 • 53 citations

Absence of 6‐Hydroxydopamine in the Rat Brain After Treatment with Stimulants and Other Dopaminergic Agents: A Mass Fragmentographic Study

1993 • 41 citations

Catecholamine Metabolism

1997 • 37 citations

Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neurons

1998 • 31 citations

Neurocircuitries and neurotransmitter interactions in schizophrenia

1995 • 28 citations

The Human Genome: Mutations

2002 • 20 citations

Prefrontal Cortical and Hippocampal Modulation of Dopamine-Mediated Effects

1997 • 15 citations

Unique and Cell-Type-Specific Tyrosine Hydroxylase Gene Expression

1997 • 11 citations

Regulation of Tyrosine Hydroxylase Gene Expression by Transsynaptic Mechanisms and Cell-Cell Contact

1997 • 7 citations