N‐Acetylaspartylglutamate

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

1993 • 510 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons

1989 • 434 citations

Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.

1996 • 360 citations

N‐Acetyl‐Aspartyl‐Glutamate: Regional Levels in Rat Brain and the Effects of Brain Lesions as Determined by a New HPLC Method

1984 • 344 citations

Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses.

1996 • 341 citations

Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.

1987 • 303 citations

N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

1997 • 295 citations

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

1999 • 281 citations

Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta.

1998 • 265 citations

Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase

1996 • 240 citations

Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-β

1998 • 230 citations

Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex

1994 • 210 citations

A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord

1993 • 197 citations

Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses

1996 • 188 citations

High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture

1986 • 181 citations

A Gas Chromatographic Method for the Determination of N‐Acetyl‐<scp>l</scp>‐Aspartic Acid, N‐Acetyl‐α‐ Aspartylglutamic Acid and β‐Citryl‐<scp>l</scp>‐Glutamic Acid and Their Distributions in the Brain and Other Organs of Various Species of Animals

1981 • 181 citations

Excitatory synaptic transmission in cultures of rat olfactory bulb

1990 • 175 citations

Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus

1996 • 151 citations

N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.

1985 • 148 citations

The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells

1994 • 132 citations

DISTRIBUTION OF N‐ACETYL‐ASPARTIC AND N‐ACETYL‐ASPARTYL‐GLUTAMIC ACIDS IN NERVOUS TISSUE*

1965 • 129 citations

Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization.

1990 • 128 citations

Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain

1995 • 125 citations

N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.

1983 • 124 citations

Immunohistochemistry and Biosynthesis of N‐Acetylaspartylglutamate in Spinal Sensory Ganglia

1987 • 116 citations

Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system

1999 • 113 citations

Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons

1992 • 111 citations

N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes

1998 • 111 citations

N‐Acetylaspartylglutamate Inhibits Forskolin‐Stimulated Cyclic AMP Levels via a Metabotropic Glutamate Receptor in Cultured Cerebellar Granule Cells

1993 • 109 citations

Folylpoly-γ-glutamate Carboxypeptidase from Pig Jejunum

1998 • 106 citations

Co‐localization of N‐acetyl‐aspartyl‐glutamate in central cholinergic, noradrenergic, and serotonergic neurons

1987 • 99 citations

Isolation and Expression of Novel Human Glutamate Carboxypeptidases with N-Acetylated α-Linked Acidic Dipeptidase and Dipeptidyl Peptidase IV Activity

1999 • 98 citations

Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

1991 • 98 citations

Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain

1986 • 92 citations

Immunocytochemical localization of the N‐acetyl‐aspartyl‐glutamate (NAAG) hydrolyzing enzyme N‐acetylated α‐linked acidic dipeptidase (NAALADase)

1992 • 91 citations

N-Acetylaspartylglutamate identified in the rat retinal ganglion cells and their projections in the brain

1987 • 83 citations

Molecular Cloning of a Peptidase Against N‐Acetylaspartylglutamate from a Rat Hippocampal cDNA Library

1997 • 83 citations

The Regional Distribution of N‐Acetylaspartylglutamate (NAAG) and Peptidase Activity Against NAAG in the Rat Nervous System

1994 • 83 citations

Selective release ofN-acetylaspartylglutamate from rat optic nerve terminals in vivo

1990 • 82 citations

Characterization of [³H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([³H]‐DCG IV) binding to metabotropic mGlu₂ receptor‐transfected cell membranes

1998 • 81 citations

Comparison of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis and N‐[³H]Acetylaspartylglutamate Binding in Rat Brain: Selective Inhibition of Phosphoinositide Hydrolysis by 2‐Amino‐3‐Phosphonopropionate

1989 • 80 citations

NAAG inhibits KCl‐induced [³H]‐GABA release via mGluR3, cAMP, PKA and L‐type calcium conductance

2001 • 80 citations

N-acetylaspartylglutamate immunoreactivity in neurons of the cat's visual system

1987 • 79 citations

Hydrolysis of the Brain Dipeptide N‐Acetyl‐l‐Aspartyl‐l‐Glutamate: Subcellular and Regional Distribution, Ontogeny, and the Effect of Lesions on N‐Acetylated‐α‐Linked Acidic Dipeptidase Activity

1988 • 77 citations

Low-concentration N-acetylaspartylglutamate suppresses the climbing fiber response of Purkinje cells in Guinea pig cerebellar slices and the responses to excitatory amino acids of Xenopus laevis oocytes injected with cerebellar mRNA

1989 • 75 citations

Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II

1998 • 75 citations

Dipeptides of glutamate and aspartate may be endogenous neuroexcitants in the rat hippocampal slice

1985 • 75 citations

N-Acetylaspartylglutamate catabolism is achieved by an enzyme on the cell surface of neurons and glia

1993 • 73 citations

N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.

1993 • 70 citations

Ultrastructural localization of N-acetylaspartylglutamate in synaptic vesicles of retinal neurons

1988 • 70 citations

IDENTIFICATION OF N‐ACETYL‐α‐ASPARTYLGLUTAMIC ACID IN THE BOVINE BRAIN

1966 • 69 citations

Interactions Between N‐Acetylaspartylglutamate and AMPA, Kainate, and NMDA Binding Sites

1994 • 69 citations

Competitive Inhibition of N‐Acetylated‐α‐Linked Acidic Dipeptidase Activity by N‐Acetyl‐L‐Aspartyl‐β‐Linked L‐Glutamate

1990 • 68 citations

N-acetylaspartylglutamate,N-acetylaspartate, andN-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer diseases

1997 • 67 citations

Calcium‐Dependent Evoked Release of N[³H]Acetylaspartylglutamate from the Optic Pathway

1988 • 64 citations

A study of possible excitatory effects of N-acetylaspartylglutamate in different in vivo and in vitro brain preparations

1984 • 64 citations

Release of N‐Acetylaspartylglutamate on Depolarization of Rat Brain Slices

1988 • 63 citations

Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate

1987 • 61 citations

Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells

1998 • 60 citations

N‐Acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes

1992 • 58 citations

N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system

1995 • 56 citations

Calcium-dependent release ofN-acetylaspartylglutamate from retinal neurons upon depolarization

1988 • 56 citations

Dual Function Glutamate-Related Ligands: Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity

2000 • 51 citations

Specific role of n-acetyl-aspartyl-glutamate in the in vivo regulation of dopamine release from dendrites and nerve terminals of nigrostriatal dopaminergic neurons in the cat

1991 • 51 citations

Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor

1996 • 48 citations

N‐acetylaspartylglutamate immunoreactivity in neurons of the monkey's visual pathway

1991 • 47 citations

Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease

1997 • 46 citations

Excitatory action of N-acetylaspartylglutamate on Purkinje cells in guinea pig cerebellar slices: an intrasomatic study

1987 • 42 citations

The characterization of the specific binding of [3H]-N- acetylaspartylglutamate to rat brain membranes

1985 • 41 citations

N‐Acetylaspartylglutamate Stimulates Metabotropic Glutamate Receptor 3 to Regulate Expression of the GABA_Aα6 Subunit in Cerebellar Granule Cells

1997 • 40 citations

An explanation for the purported excitation of piriform cortical neurons by N-acetyl-L-aspartyl-L-glutamic acid (NAAG).

1989 • 39 citations

Localization and Synaptic Release of N‐acetylaspartyl‐glutamate in the Chick Retina and Optic Tectum

1991 • 39 citations

Electrophysiological and pharmacological actions of N-acetylaspartylglutamate intracellularly studied in cultured chick cerebellar neurons

1987 • 39 citations

Cellular localization of N-acetylaspartylglutamate in amphibian retina and spinal sensory ganglia

1987 • 38 citations

Purification, cDNA Cloning, and Expression of a New Human Blood Plasma Glutamate Carboxypeptidase Homologous toN-Acetyl-aspartyl-α-glutamate Carboxypeptidase/Prostate-specific Membrane Antigen

1999 • 37 citations

Localization and Transport of N‐Acetylaspartylglutamate in Cells of Whole Murine Brain in Primary Culture

1993 • 37 citations

Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures

1998 • 37 citations

N-acetyl-aspartylglutamate: binding sites and excitatory action in the dorsolateral septum of rats

1987 • 36 citations

Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay

1988 • 36 citations

Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors

1984 • 36 citations

N-Acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo

1997 • 35 citations

Immunocytochemical distribution of n-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways

1993 • 35 citations

Release of N‐Acetylaspartylglutamate from Slices of Rat Cerebellum, Striatum, and Spinal Cord, and the Effect of Climbing Fiber Deprivation

1994 • 32 citations

Comparative distribution of N‐Acetylaspartylglutamate and GAD₆₇ in the cerebellum and precerebellar nuclei of the rat utilizing enhanced carbodiimide fixation and immunohistochemistry

1994 • 32 citations

N-Acetylaspartylglutamate Selectively Inhibits Neuronal Responses to N-Methyl-d-Aspartic Acid In Vitro

1994 • 31 citations

Light and electron microscopic immunohistochemical localization of N-acetylaspartylglutamate NAAG in the olivocerebellar pathway of the rat

1997 • 31 citations

Evidence for the presence of N-acetylaspartylglutamate in cultured oligodendrocytes and LPS activated microglia

1998 • 31 citations

Regional brain levels of N-acetyl-aspartyl-glutamate: the effect of kindled seizures

1985 • 29 citations

Uptake, Metabolism, and Release of N‐[³H]‐Acetylaspartylglutamate by the Avian Retina

1992 • 29 citations

Blockade of NAALADase: A Novel Neuroprotective Strategy Based on Limiting Glutamate and Elevating NAAG

1999 • 27 citations

Depolarization-evoked release of N-acetyl-L-aspartlyl-L-glutamate from rat brain synaptosomes

1988 • 27 citations

Induction of long-lasting depression by (+)-α-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro

1999 • 27 citations

N-Acetylaspartylglutamate

1988 • 23 citations

The action of the putative neurotransmitters N-acetylaspartylglutamate and L-homocysteate in cat dorsal lateral geniculate nucleus

1992 • 23 citations

N-Acetylated alpha-linked acidic dipeptidase may be involved in axon-Schwann cell signalling

1996 • 22 citations

N-acetyl-aspartylglutamate (NAAG) elicits rapid increase in intraneuronal Ca2+ in vitro

1994 • 22 citations

Seizures decrease regional enzymatic hydrolysis of N-acetyl-aspartylglutamate in rat brain

1989 • 21 citations

Production and characterization of monoclonal antibodies to N-acetyl-aspartyl-glutamate.

1990 • 17 citations

A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites

1988 • 14 citations

Release of endogenous N-acetylaspartylglutamate (NAAG) and uptake of [3H]NAAG in Guinea pig cerebellar slices

1989 • 12 citations

NAALADase inhibition protects motor neurons against chronic glutamate toxicity

2003 • 11 citations

N-acetylaspartylglutamate. A neuropeptide in the human visual system

1988 • 11 citations

N‐Acetylsuccinimidylglutamate, a Cyclic Imide Form of the Peptide N‐Acetylaspartylglutamate, Is Present in Low Micromolar Concentrations in Murine and Bovine CNS

1996 • 4 citations

Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase

1992 • 4 citations