Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Principles of Population Genetics.

1990 • 5,413 citations

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

Consed: A Graphical Tool for Sequence Finishing

1998 • 3,325 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous

2002 • 1,798 citations

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

1996 • 1,780 citations

Genetics of populations

1983 • 1,542 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

TRANSFAC: an integrated system for gene expression regulation

2000 • 1,236 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

1999 • 1,023 citations

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

1997 • 946 citations

Haplotype Variation and Linkage Disequilibrium in 313 Human Genes

2001 • 879 citations

Racial variability in the UDP-glucuronosyltransferase 1 ( UGT1A1 ) promoter: A balanced polymorphism for regulation of bilirubin metabolism?

1998 • 833 citations

Computer Programmes for Processing Enzyme Kinetic Data

1963 • 655 citations

Catechol-O-methyl transferase: pharmacological aspects and physiological role.

1975 • 547 citations

An E-M algorithm and testing strategy for multiple-locus haplotypes.

1995 • 544 citations

Crystal structure of catechol O-methyltransferase

1994 • 426 citations

Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism

2000 • 413 citations

Principles of population genetics (2nd edn)

1989 • 404 citations

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

1999 • 371 citations

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

1994 • 332 citations

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder

1997 • 311 citations

Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism

1996 • 310 citations

Characterization and Implications of Estrogenic Down-Regulation of Human Catechol-O-Methyltransferase Gene Transcription

1999 • 297 citations

Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1→q11.2

1992 • 295 citations

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

1997 • 286 citations

Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes

1989 • 254 citations

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

1977 • 248 citations

Human liver catechol-O-methyltransferase pharmacogenetics

1990 • 243 citations

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

1997 • 222 citations

Genetics of Populations (2nd edn). Philip W. Hedrick. Jones and Bartlett Publishers, Sudbury, MA. 2000. Pp. 553. Price £26.99, hardback. ISBN 0 7637 1076 8.

2000 • 215 citations

Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1

2001 • 211 citations

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

1991 • 197 citations

Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA

1991 • 166 citations

Catechol- O -Methyltransferase: Thermolabile Enzyme in Erythrocytes of Subjects Homozygous for Allele for Low Activity

1979 • 151 citations

Human HistamineN-Methyltransferase Pharmacogenetics: Common Genetic Polymorphisms that Alter Activity

1998 • 134 citations

High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease

1997 • 128 citations

Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the O-methylation of the catecholamine neurotransmitters

1992 • 123 citations

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells

1999 • 119 citations

Association studies of bipolar disorder

2001 • 116 citations

Genetics of red cell COMT activity: Analysis of thermal stability and family data

1981 • 113 citations

Microassay of human erythrocyte catechol-O-methyltransferase: Removal of inhibitory calcium ion with chelating resin

1975 • 105 citations

Human Liver Thermolabile Phenol Sulfotransferase: cDNA Cloning, Expression and Characterization

1994 • 88 citations

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies

2002 • 88 citations

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene

1998 • 79 citations

Heterozygote and mutation detection by direct automated fluorescent DNA sequencing using a mutant Taq DNA polymerase.

1996 • 76 citations

Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.

1994 • 73 citations

Association between homozygosity at the COMT gene locus and obsessive compulsive disorder

2000 • 69 citations

Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population

2001 • 62 citations

Human erythrocyte catechol-o-methyltransferase: Correlation with lung and kidney activity

1978 • 61 citations

Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation

2002 • 55 citations

Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies

2001 • 52 citations

Deconstructing Schizophrenia

2003 • 51 citations

The Inheritance of human erythrocyte catechol‐O‐methyltransferase activity

1981 • 46 citations

Human 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes

2002 • 41 citations

Major gene model for the inheritance of catechol‐o‐methyltransferase activity in five large families

1984 • 22 citations

Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population

2000 • 22 citations

Low catechol-O-methyltransferase activity in a Saami population

1994 • 18 citations

Meta-analysis of polymorphism of the catechol-O-methyltransferase gene in relation to the etiology of Parkinson's disease in Japan

2000 • 11 citations

Thiopurine S‐Methyltransferase (TPMT) Pharmacogenetics: Role of Chaperone Proteins in variant Allozyme Degradation

2003 • 7 citations