Pre‐and Postmortem Influences on Brain RNA

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

Convulsant-induced increase in transcription factor messenger RNAs in rat brain.

1988 • 377 citations

The role of mRNA and protein stability in gene expression

1989 • 370 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

REGULATED mRNA STABILITY

1990 • 279 citations

MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE

1989 • 266 citations

Enzyme Activities in Relation to pH and Lactate in Postmortem Brain in Alzheimer‐Type and Other Dementias

1990 • 252 citations

Extensive postmortem stability of RNA from rat and human brain

1986 • 226 citations

Chronic ethanol causes heterologous desensitization of receptors by reducing αsmessenger RNA

1988 • 220 citations

Neuronal activity up-regulates astroglial gene expression.

1991 • 206 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia

1990 • 199 citations

The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue

1985 • 186 citations

Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study

1989 • 178 citations

Alzheimer's Disease Brain: Alterations in RNA Levels and in a Ribonuclease-Inhibitor Complex

1984 • 173 citations

Chapter 27 Chapter Seizures, neuropeptide regulation, and mRNA expression in the hippocampus

1990 • 166 citations

Changes in hypothalamic preproenkephalin A mRNA following stress and opiate withdrawal

1987 • 161 citations

Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization

1987 • 145 citations

Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in parkinson's disease: An in situ hybridization study

1990 • 143 citations

RNA metabolism: strategies for regulation in the heat shock response

1990 • 142 citations

Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex.

1989 • 136 citations

Post‐mortem stability of dopamine. glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material

1978 • 122 citations

Alzheimer's disease-associated reduction of polysomal mRNA translation

1989 • 113 citations

Haloperidol increases proenkephalin mRNA levels in the caudate-putamen of the rat: a quantitative study at the cellular level using in situ hybridization

1987 • 109 citations

Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock

1989 • 106 citations

Effects of Postmortem Delay and Temperature on Neurotransmitter Receptor Binding in a Rat Model of the Human Autopsy Process

1984 • 105 citations

Splicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone.

1991 • 84 citations

Insulin-Induced Hypoglycemia Increases Corticotropin- Releasing Factor Messenger Ribonucleic Acid Levels in Rat Hypothalamus*

1988 • 83 citations

A Comparison of Methodologies for the Study of Functional Transmitter Neurochemistry in Human Brain

1988 • 83 citations

Characterization of Messenger RNA from the Cerebral Cortex of Control and Alzheimer‐Afflicted Brain

1986 • 80 citations

Synthesis of plasma proteins in fetal, adult, and neoplastic human brain tissue

1986 • 80 citations

Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

1991 • 78 citations

Effect of pre- and postmortem variables on specific mRNA levels in human brain

1991 • 74 citations

Terminal coma affects messenger RNA detection in post mortem human temporal cortex

1991 • 72 citations

Altered expression of genes for amyloid and cytoskeletal proteins in alzheimer cortex

1989 • 70 citations

Characterisation of messenger RNA extracted post-mortem from the brains of schizophrenic, depressed and control subjects.

1988 • 70 citations

The isolation and in vitro translation of undegraded messenger RNAs from human postmortem brain

1981 • 67 citations

Cholinergic Neurons of the Nucleus basalis Express Elevated Levels of Nerve Growth Factor Receptor mRNA in Senile Dementia of the Alzheimer Type

1990 • 65 citations

On the Stability of Messenger RNA and Ribosomal RNA in the Brains of Control Human Subjects and Patients with Alzheimer's Disease

1992 • 63 citations

In situ hybridization histochemistry and the study of gene expression in the human brain

1990 • 62 citations

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

1990 • 59 citations

Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.

1988 • 56 citations

Recovery and measurement of specific RNA species from postmortem brain tissue: A general reduction in Alzheimer's disease detected by molecular hybridization

1986 • 55 citations

Alzheimer's disease: specific increases in a G protein subunit (GSα) mRNA in hippocampal and cortical neurons

1991 • 55 citations

Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-1 mRNA in alzheimer brains

1991 • 54 citations

Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry

1991 • 53 citations

Heat shock protein (hsx70) mRNA expression in human brain: effects of neurodegenerative disease and agonal state

1993 • 51 citations

The Preparation of Biologically Active Messenger RNA from Human Postmortem Brain Tissue

1981 • 47 citations

Changes in gene expression in hippocampus in response to glucocorticoids and stress

1990 • 44 citations

Stability of messenger RNA in postmortem human brains and construction of human brain cDNA libraries

1990 • 43 citations

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

1991 • 42 citations

Regional distribution of the messenger RNA coding for the neuropeptide cholecystokinin in the human brain examined by in situ hybridization

1990 • 40 citations

Molecular events regulating messenger RNA stability in eukaryotes

1990 • 40 citations

Are post-mortem biochemical studies of human brain worthwhile?

1988 • 40 citations

Regional distribution of messenger RNAs in postmortem human brain

1986 • 39 citations

Quantitative approaches for studying gene expression

1991 • 38 citations

Cytoskeletal Messenger RNA Stability in Human Neocortex: Studies in Normal Aging and in Alzheimer's Disease

1990 • 34 citations

Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain

1991 • 34 citations

PROTEIN AND NUCLEIC ACID CONTENT IN THE AGING HUMAN BRAIN*

1979 • 33 citations

Mechanisms of mRNA decay

1990 • 31 citations

Distribution of a kainate/ AMPA receptor mRNA in normal and Alzheimer brain

1990 • 31 citations

The use ofin situ hybridization histochemistry for the study of neuropeptide gene expression in the human brain

1990 • 30 citations

Preproenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation

1989 • 29 citations

Localization and regulation of vasopressin mRNA in human neurons

1989 • 25 citations

The postmortem Alzheimer brain is a source of structurally and functionally intact astrocytic messenger RNA

1988 • 25 citations

Polyadenylated Messenger RNA in Paired Helical Filament-Immunoreactive Neurons in Alzheimer Disease

1990 • 20 citations

Effect of anoxia and ischemia on ribonuclease activity in brain

1979 • 19 citations

A study of non-isotopic in situ hybridization histochemistry on postmortem changes in vasopressin mRNA in rat brain

1989 • 18 citations

A study on postmortem stability of vasopressin messenger RNA in rat brain compared with those in total RNA and ribosomal RNA

1991 • 18 citations

Expressional potency of mRNAs encoding receptors and voltage-activated channels in the postmortem rat brain.

1991 • 18 citations

Decrease in mRNA levels but not in the density of D2 dopamine receptors in rat striatum after transient forebrain ischemia

1991 • 18 citations

Rapid autopsy brains for biochemical research: Experiences in establishing a programme

1990 • 17 citations

Polyadenylated Messenger RNA in Paired Helical Filament-Immunoreactive Neurons in Alzheimer Disease

1990 • 17 citations

Study of pro-opiomelanocortin mRNA expression in human postmortem pituitaries

1991 • 17 citations

Circadian rhythms of calcitonin gene expression in the rat

1989 • 17 citations

Neuronal gene expression in amyotrophic lateral sclerosis

1990 • 15 citations

Stereospecific effect of flupenthixol on neuroreceptor gene expression

1991 • 14 citations

Cloning of the cDNA from normal brain and brain of patients with Alzheimer's disease in the expression vector lambda GT 11

1988 • 11 citations

In vitro study of the biological activity of RNAs after incubation of hog liver, heart and brain tissue at room temperature

1985 • 8 citations

Effects of Cap Analogue or Cap Removal on the Translation of Rat Brain mRNA In Vitro

1982 • 8 citations

The impact of molecular genetics on clinical neurology

1986 • 7 citations

Changes in brain gene expression in schizophrenic and depressed patients

1992 • 6 citations

Characterization of polysomes purified from human postmortem brain tissues

1990 • 6 citations

Stability of brain RNA post mortem: effect of Alzheimer's disease

1987 • 4 citations