Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment

Principles of neural science

1982 • 9,410 citations

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

2016 • 8,701 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Principles of Neural Science

1992 • 2,515 citations

Lipid peroxidation: its mechanism, measurement, and significance

1993 • 2,324 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

2000 • 1,565 citations

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

2001 • 1,479 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort

1994 • 1,326 citations

Schizophrenia: a disconnection syndrome?

1995 • 1,310 citations

Synaptic plasticity: LTP and LTD

1994 • 1,301 citations

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder

1999 • 1,258 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

Glutamate receptors in the mammalian central nervous system

1998 • 1,126 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

2001 • 1,080 citations

Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia

1999 • 1,063 citations

NMDA receptor hypofunction model of schizophrenia

1999 • 1,007 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

Dopamine receptor pharmacology

1994 • 959 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia

2001 • 915 citations

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1993 • 893 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

2000 • 872 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Ca ²⁺ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors

1999 • 836 citations

Catching Up on Schizophrenia

2000 • 815 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

Synaptogenesis in human visual cortex — evidence for synapse elimination during normal development

1982 • 747 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

2000 • 728 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Clinical and Theoretical Implications of 5-HT₂ and D₂ Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

1999 • 706 citations

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis

1998 • 702 citations

Toward a molecular definition of long-term memory storage

1996 • 685 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

The Role of Serotonin in Antipsychotic Drug Action

1999 • 672 citations

Regulation of NMDA receptors by tyrosine kinases and phosphatases

1994 • 671 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test

2000 • 645 citations

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

1995 • 639 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia

1998 • 608 citations

Assembly of presynaptic active zones from cytoplasmic transport packets

2000 • 602 citations

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM

1997 • 596 citations

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 • 590 citations

Lateral Cerebral Ventricular Enlargement in Chronic Schizophrenia

1979 • 579 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

2001 • 569 citations

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

1996 • 558 citations

D-serine added to antipsychotics for the treatment of schizophrenia

1998 • 557 citations

Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.

1993 • 552 citations

Maturation of a Central Glutamatergic Synapse

1996 • 551 citations

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

1976 • 543 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

1997 • 538 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

Neurotransmitters in the regulation of neuronal cytoarchitecture

1988 • 525 citations

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

2000 • 520 citations

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

1997 • 517 citations

Structure, development, and plasticity of dendritic spines

1999 • 511 citations

Excitotoxicity and the NMDA receptor -- still lethal after eight years

1995 • 504 citations

Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses

1999 • 496 citations

Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

1998 • 493 citations

Assembly of New Individual Excitatory Synapses

2000 • 490 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Schizophrenia

1994 • 489 citations

Schizophrenia as a Long-Term Outcome of Pregnancy, Delivery, and Perinatal Complications: A 28-Year Follow-Up of the 1966 North Finland General Population Birth Cohort

1998 • 486 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

Genetics of programmed cell death in C. elegans: past, present and future

1998 • 486 citations

Efficacy of High-Dose Glycine in the Treatment of Enduring Negative Symptoms of Schizophrenia

1999 • 484 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Electrophysiological studies of NMDA receptors

1987 • 483 citations

Neuroleptics increase C-FOS expression in the forebrain: Contrasting effects of haloperidol and clozapine

1992 • 477 citations

Is schizophrenia a neurodegenerative disorder? a clinical and neurobiological perspective

1999 • 476 citations

Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

1997 • 470 citations

Molecular mechanisms of calcium-dependent excitotoxicity

2000 • 467 citations

Neural apoptosis

1995 • 464 citations

Determinants of ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing

1993 • 453 citations

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

1992 • 445 citations

Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia

1998 • 441 citations

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

1996 • 440 citations

A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia

1999 • 435 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

1997 • 434 citations

Neuromotor Precursors of Schizophrenia

1994 • 434 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

1992 • 416 citations

Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism

1998 • 413 citations

Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

1995 • 411 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Glutamate receptor expression in schizophrenic brain

2000 • 401 citations

Neuroimaging studies of the hippocampus in schizophrenia

2001 • 399 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat*1

1989 • 375 citations

Expression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation

1999 • 374 citations

CREB: A mediator of long-term memory from mollusks to mammals

1994 • 371 citations

Ionotropic Glutamate Receptors and Expression ofN-Methyl-<scp>d</scp>-Aspartate Receptor Subunits in Subregions of Human Hippocampus: Effects of Schizophrenia

2000 • 366 citations

5-HT₂ and D₂ Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation

1998 • 364 citations

Amelioration of negative symptoms in schizophrenia by glycine

1994 • 349 citations

D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons

1990 • 344 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

Synapse elimination and plasticity in developing human cerebral cortex.

1984 • 337 citations

Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine.

1992 • 334 citations

Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptor

1991 • 333 citations

Differential Hippocampal Expression of Glutamic Acid Decarboxylase 65 and 67 Messenger RNA in Bipolar Disorder and Schizophrenia

2002 • 322 citations

Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases

1997 • 316 citations

Molecular Physiology of Kainate Receptors

2001 • 310 citations

Receptor pharmacology of neuroleptics: relation to clinical effects.

1999 • 309 citations

Schizophrenia: the fundamental questions

2000 • 308 citations

Molecular determinants of metabotropic glutamate receptor signaling

2001 • 307 citations

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons

2001 • 305 citations

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.

1994 • 304 citations

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.

1993 • 304 citations

Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor

1996 • 302 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

Sustained Dendritic Gradients of Ca ²⁺ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons

1988 • 301 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

3 Regulation of ligand-gated ion channels by protein phosphorylation

1999 • 297 citations

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

2000 • 294 citations

Slices Have More Synapses than Perfusion-Fixed Hippocampus from both Young and Mature Rats

1999 • 292 citations

Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs

1997 • 284 citations

An overview of the mechanism of action of clozapine.

1994 • 283 citations

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

1997 • 280 citations

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

2000 • 278 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

Magnetic Resonance Imaging Abnormalities in Lenticular Nuclei and Cerebral Cortex in Schizophrenia

1991 • 271 citations

Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors

2001 • 270 citations

Association of Schizophrenia With Low Maternal Body Mass Index, Small Size at Birth, and Thinness During Childhood

2001 • 265 citations

Motoneuron-Specific Expression of NR3B, a Novel NMDA-Type Glutamate Receptor Subunit That Works in a Dominant-Negative Manner

2001 • 255 citations

Double-Blind, Placebo-Controlled, Crossover Trial of Glycine Adjuvant Therapy for Treatment-Resistant Schizophrenia

1996 • 253 citations

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1989 • 250 citations

Markers of Glutamatergic Neurotransmission and Oxidative Stress Associated With Tardive Dyskinesia

1998 • 247 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

Quantitative Neuroanatomy in Schizophrenia

1988 • 241 citations

Decreased hippocampal expression of a glutamate receptor gene in schizophrenia

1991 • 241 citations

Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia

1995 • 238 citations

Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. III. CREB Is Necessary for Presynaptic Functional Plasticity

1996 • 236 citations

Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors

1997 • 235 citations

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: CytochromecRelease and a Secondary Increase in Superoxide Production

2000 • 233 citations

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

1998 • 229 citations

Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis

1992 • 225 citations

<scp>d-</scp>Serine Added to Clozapine for the Treatment of Schizophrenia

1999 • 224 citations

Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia

1995 • 216 citations

Schizophrenic Birth Seasonality in Relation to the Incidence of Infectious Diseases and Temperature Extremes

1984 • 216 citations

Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia?

1995 • 215 citations

Childhood precursors of schizophrenia: facial expressions of emotion

1993 • 215 citations

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia

1995 • 213 citations

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

1988 • 210 citations

Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats

2000 • 209 citations

Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia

1998 • 209 citations

A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia

2001 • 208 citations

Facilitated Glutamatergic Transmission in the Striatum of D₂ Dopamine Receptor-Deficient Mice

2001 • 204 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study.

1988 • 201 citations

Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia

1983 • 201 citations

Roles of metabotropic glutamate receptors in LTP and LTD in

1999 • 196 citations

CaMKII regulates the density of central glutamatergic synapses in vivo

1999 • 196 citations

Critical Dependence of cAMP Response Element-Binding Protein Phosphorylation on L-Type Calcium Channels Supports a Selective Response to EPSPs in Preference to Action Potentials

2000 • 195 citations

Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia

2001 • 195 citations

Genetic animal models: focus on schizophrenia

2001 • 194 citations

Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro

1999 • 190 citations

Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin- dependent protein kinase II and protein kinase C in cultured hippocampal neurons

1994 • 188 citations

D-cycloserine added to clozapine for patients with schizophrenia

1996 • 184 citations

Synaptic kainate receptors

2000 • 181 citations

A placebo-controlled crossover trial of d-cycloserine added to clozapine in patients with schizophrenia

1999 • 179 citations

Clozapine is a potent and selective muscarinic M4 receptor agonist

1994 • 179 citations

Molecular mechanisms associated with long-term consolidation of the NMDA signals

2000 • 179 citations

Placebo-Controlled Trial of Glycine Added to Clozapine in Schizophrenia

2000 • 174 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

Neuropathology of Schizophrenia: Cortex, Thalamus, Basal Ganglia, and Neurotransmitter-specific Projection Systems

1997 • 172 citations

The role of cell adhesion molecules in synaptic plasticity and memory

1999 • 172 citations

N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells

1990 • 171 citations

Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs

1995 • 171 citations

Role of Caspases in N‐Methyl‐<scp>d</scp>‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons

1998 • 170 citations

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

1993 • 170 citations

Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders

1995 • 170 citations

Control of NMDA Receptor Activation by a Glycine Transporter Co-Expressed inXenopusOocytes

1997 • 170 citations

d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes

1990 • 168 citations

L-Type Ca²⁺Channels Are Essential for Glutamate-Mediated CREB Phosphorylation andc-fosGene Expression in Striatal Neurons

1999 • 168 citations

Evidence for altered trisynaptic circuitry in schizophrenic hippocampus

1999 • 167 citations

Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit.

2001 • 166 citations

Maternal influenza, obstetric complications, and schizophrenia

1995 • 164 citations

Dopamine Terminals in the Rat Prefrontal Cortex Synapse on Pyramidal Cells that Project to the Nucleus Accumbens

1999 • 162 citations

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1997 • 158 citations

Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia

1997 • 158 citations

Cerebral Ventricular Enlargement in Schizophrenia

1986 • 158 citations

Dorsal Striatal Size, Shape, and Metabolic Rate in Never-Medicated and Previously Medicated Schizophrenics Performing a Verbal Learning Task

1998 • 158 citations

Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja

1994 • 156 citations

Tardive dyskinesia: pathophysiology and animal models.

2000 • 156 citations

Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study

1991 • 154 citations

Evidence of glutamatergic deficiency in schizophrenia

1991 • 154 citations

Childhood Neuromotor Dysfunction in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study

2000 • 153 citations

Hyperfunction of Dopaminergic and Serotonergic Neuronal Systems in Mice Lacking the NMDA Receptor ε1 Subunit

2001 • 152 citations

Intracellular Modulation of NMDA Receptor Function by Antipsychotic Drugs

2000 • 150 citations

Gliosis in schizophrenia: A survey

1986 • 150 citations

Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia

1991 • 148 citations

Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons

2000 • 148 citations

The effects of antipsychotic drugs on fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization

1996 • 147 citations

NMDA‐induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria

1998 • 146 citations

Epidemiology and natural history of schizophrenia

1999 • 145 citations

Extrapyramidal side effects, tardive dyskinesia, and the concept of atypicality.

2000 • 143 citations

Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness

1994 • 141 citations

Effect of Clozapine and Adjunctive High-Dose Glycine in Treatment-Resistant Schizophrenia

1999 • 140 citations

Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia

1991 • 139 citations

Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor.

1990 • 139 citations

Postsynaptically Silent Synapses in Single Neuron Cultures

1998 • 138 citations

The neural cell adhesion molecule and synaptic plasticity

1995 • 138 citations

Schizophrenia: a disorder of neurodevelopment?

1997 • 134 citations

Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers

1995 • 133 citations

Dopamine receptor pharmacology.

1993 • 133 citations

A PET Study of 5-HT2 and D2 Dopamine Receptor Occupancy Induced by Olanzapine in Healthy Subjects

1997 • 132 citations

Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats

1998 • 131 citations

Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic receptors in vivo in rats

1996 • 131 citations

Review Article Reciprocaldopamine-glutamatemodulation of release in the basalganglia

1998 • 129 citations

The effects of haloperidol on synaptic patterns in the rat striatum

1985 • 127 citations

Binding of Antipsychotic Drugs to Cortical 5-HT_2A Receptors: A PET Study of Chlorpromazine, Clozapine, and Amisulpride in Schizophrenic Patients

1998 • 125 citations

Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine — a123 IBZM single photon emission tomography (SPET) study

1996 • 124 citations

Lipid Peroxides in the Free Radical Pathophysiology of Brain Diseases

1998 • 124 citations

Tardive dyskinesia and atypical antipsychotic drugs

1999 • 124 citations

Rapid dendritic movements during synapse formation and rearrangement

2000 • 123 citations

Synaptic innervation of midbrain dopaminergic neurons by glutamate-enriched terminals in the squirrel monkey

1996 • 123 citations

Arachidonic acid modulates hippocampal calcium current via protein kinase C and oxygen radicals

1990 • 122 citations

The role of postsynaptic calcium in the induction of long-term potentiation

1991 • 122 citations

Prevalence of spontaneous dyskinesia in schizophrenia.

2000 • 122 citations

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1989 • 118 citations

Cold thoughts of death: the role of ICE proteases in neuronal cell death

1996 • 118 citations

Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

1993 • 118 citations

Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996 • 118 citations

Computed Tomographic Evidence for Generalized Sulcal and Ventricular Enlargement in Schizophrenia

1988 • 117 citations

Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

2000 • 116 citations

The changing roles and targets for animal models of schizophrenia

2001 • 114 citations

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

1994 • 114 citations

Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

2000 • 110 citations

Protein phosphorylation in neuronal plasticity and gene expression

1995 • 107 citations

Actions of ?-cycloserine at the ? glycine receptor site in vivo

1991 • 105 citations

GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT–PCR) study

1997 • 103 citations

Development of neuron–neuron synapses

2000 • 103 citations

Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain

1998 • 102 citations

Expected incidence of tardive dyskinesia associated with atypical antipsychotics.

2000 • 100 citations

Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia

1997 • 100 citations

Striatal enlargement in rats chronically treated with neuroleptic

1998 • 100 citations

Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains

1997 • 99 citations

Dopamine and the pharmacology of schizophrenia: The state of the evidence

1974 • 99 citations

The role of superoxide dismutation in malaria parasites.

1998 • 97 citations

Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons

1998 • 96 citations

Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.

1995 • 94 citations

Glutamate in schizophrenia: clinical and research implications

1997 • 94 citations

Phencyclidine: an overview.

1978 • 93 citations

D2 and 5-HT2 receptor effects of antipsychotics: bridging basic and clinical findings using PET.

1999 • 92 citations

Activity-Dependent Induction of Tonic Calcineurin Activity Mediates a Rapid Developmental Downregulation of NMDA Receptor Currents

2000 • 91 citations

Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus

2000 • 91 citations

Obstetric complications in histories of monozygotic twins discordant and concordant for schizophrenia

1994 • 91 citations

Alterations in phencyclidine and sigma binding sites in schizophrenic brains

1991 • 90 citations

Modulation of dopamine neuronal activity by glutamate receptor subtypes

1997 • 89 citations

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.

1996 • 88 citations

Kainic acid induces apoptosis in neurons

1996 • 88 citations

The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia

2001 • 88 citations

NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia

1999 • 88 citations

Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons.

1995 • 87 citations

Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain

1995 • 86 citations

Confirmation of reduced temporal limbic structure volume on magnetic resonance imaging in male patients with schizophrenia

1996 • 86 citations

Involvement of adenosine and glutamate receptors in the induction ofc-fos in the striatum by haloperidol

1996 • 85 citations

Calcium/calmodulin-dependent protein kinase II: role in learning and memory

1993 • 83 citations

Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs.

1997 • 82 citations

Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors

1999 • 82 citations

Excitatory transmitter neurotoxicity

1994 • 82 citations

Synergistic interactions between ampakines and antipsychotic drugs.

1999 • 82 citations

Metabotropic G-protein-coupled glutamate receptors as therapeutic targets

1999 • 76 citations

Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia

2000 • 75 citations

Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus

2000 • 74 citations

Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment

1995 • 72 citations

Which characteristics of schizophrenia predate psychosis?

1998 • 71 citations

5-HT_2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine

1998 • 69 citations

Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

1997 • 69 citations

Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment

1991 • 68 citations

Effects of Subchronic Clozapine and Haloperidol on Striatal Glutamatergic Synapses

1996 • 67 citations

First Images of a Glutamate Receptor Ion Channel: Oligomeric State and Molecular Dimensions of GluRB Homomers

2001 • 67 citations

Spontaneous dyskinesia in first episode schizophrenia

1999 • 67 citations

Glutamate agonist activity

1995 • 65 citations

An Analysis of Contemporary Morphological Concepts of Synaptic Remodelling in the CNS: Perforated Synapses Revisited

1995 • 62 citations

Rapid plasticity of dendritic spine: hints to possible functions?

2001 • 62 citations

Synaptic Plasticity in the Rat Striatum following Chronic Haloperidol Treatment

1992 • 61 citations

Antipsychotics from theory to practice: integrating clinical and basic data.

1999 • 60 citations

Comparative analysis of group II metabotropic glutamate receptor immunoreactivity in Brodmann's area 46 of the dorsolateral prefrontal cortex from patients with schizophrenia and normal subjects

2002 • 59 citations

Mitochondria, glutamate neurotoxicity and the death cascade

1998 • 59 citations

Haloperidol interacts with the strychnine-insensitive glycine site at the NMDA receptor in cultured mouse hippocampal neurones

1993 • 58 citations

Small head circumference at birth in schizophrenia

1996 • 56 citations

Sealing one's fate: control of cell death in neurons

1998 • 56 citations

The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum

1993 • 55 citations

Glycinergic augmentation of NMDA receptor-mediated neurotransmission in the treatment of schizophrenia.

1996 • 53 citations

Striatal N-methyl-D-aspartate receptors in haloperidol-induced catalepsy

1991 • 51 citations

Antipsychotic drug effects on glutamatergic activity

1997 • 50 citations

Tardive dyskinesia and substrates of energy metabolism in CSF

1995 • 50 citations

Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors.

1996 • 50 citations

Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): analysis of association with schizophrenia

2001 • 49 citations

Phencyclidine: An Overview

1977 • 49 citations

NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonists

1993 • 48 citations

Spontaneous Dyskinesia in Subjects With Schizophrenia Spectrum Personality

1998 • 47 citations

Increased density of glutamate/N-methyl-d-aspartate receptors in putamen from schizophrenic patients

1998 • 46 citations

Increased density of glutamate/N-methyl-d-aspartate receptors in superior temporal cortex in schizophrenia

2001 • 45 citations

Cell Death in C. elegans: Molecular insights into Mechanisms Conserved Between Nematodes and Mammals

1996 • 45 citations

NMDA-Dependent Modulation of Hippocampal Kainate Receptors by Calcineurin and Ca²⁺/Calmodulin-Dependent Protein Kinase

2000 • 44 citations

In vivo determination of striatal dopamine D2 receptor occupancy in patients treated with olanzapine

1999 • 44 citations

Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia

2001 • 43 citations

Pharmacologic treatment of schizophrenia.

1991 • 43 citations

Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia

1999 • 43 citations

The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain

1996 • 43 citations

ICE-like proteases execute the neuronal death program

1996 • 42 citations

Combined antagonism of adrenoceptors and dopamine and 5-HT receptors underlies the atypical profile of clozapine

1994 • 42 citations

The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits

1990 • 42 citations

Pieces of the Schizophrenia Puzzle Fall into Place

1996 • 42 citations

Expression of N-Methyl-D-Aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons

1998 • 41 citations

Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.

1997 • 39 citations

The biochemical pharmacology of metabotropic glutamate receptors

1993 • 38 citations

An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.

1998 • 35 citations

Chronic haloperidol treatment impairs glutamate transport in the rat striatum

1999 • 35 citations

Impairments of movement initiation and execution induced by a blockade of dopamine D1 OR D2 receptors are reversed by a blockade of N-methyl-d-aspartate receptors

1996 • 34 citations

Time course of cerebral ventricular enlargement in schizophrenia supports the hypothesis of its neurodevelopmental nature

1997 • 33 citations

Differential effects of unique profile antipsychotic drugs on extracellular amino acids in the ventral pallidum and globus pallidus of rats.

1996 • 32 citations

The NMDA positive modulatord-cycloserine potentiates the neuroleptic activity of D1 and D2 dopamine receptor blockers in the rat

1993 • 32 citations

Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats

1999 • 31 citations

Comparison of chronic intermittent haloperidol and raclopride effects on striatal dopamine release and synaptic ultrastructure in rats

1992 • 31 citations

Modulation of the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor by Haloperidol: NR2B‐Specific Interactions

1998 • 31 citations

Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons

1999 • 30 citations

MK 801 reverses haloperidol-induced catalepsy from both striatal and extrastriatal sites in the rat brain

1997 • 30 citations

Expression of messenger RNAs encoding ionotropic glutamate receptors in rat brain: regulation by haloperidol

1998 • 29 citations

Conventional versus novel antipsychotics: changing concepts and clinical implications.

1999 • 29 citations

Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia

2001 • 28 citations

EMERGING ROLES FOR NOVEL ANTIPSYCHOTIC MEDICATIONS IN THE TREATMENT OF SCHIZOPHRENIA

1998 • 26 citations

Reactive gliosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex: GFAP evaluation by sandwich ELISA and immunocytochemistry.

1995 • 26 citations

Neuropathological studies of brain tissue in schizophrenia

1997 • 24 citations

Neurodevelopmental Schizophrenia: Obstetric Complications, Birth Weight, Premorbid Social Withdrawal and Learning Disabilities

2001 • 23 citations

No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia

2000 • 21 citations

Activation of apoptosis-linked caspase(s) in NMDA-injured brains in neonatal rats

2000 • 20 citations

NMDA regulation of dopamine release from proximal and distal dendrites in the cat substantia nigra

1994 • 18 citations

Synaptic plasticity: Building memories to last

2000 • 16 citations

Neuroleptic effects on serine and glycine metabolism

1993 • 15 citations

Failure to down regulate NMDA receptors in the striatum and nucleus accumbens associated with neuroleptic-induced dyskinesia

1998 • 12 citations

Identity of peroxy radicals produced from arachidonic acid in oxygenated solutions as studied by pulse radiolysis technique

1982 • 11 citations

Mechanisms of destabilization of Ca2+-homeostasis of brain neurons caused by toxic glutamate challenge.

2000 • 11 citations

Evidence for NMDA/D2 receptor-receptor interactions in the rat striatum.

1993 • 8 citations

Prefabrication provides synapses on demand

2000 • 3 citations

Spontaneous dyskinesia in schizophrenia spectrum personality

1997 • 2 citations