The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

1990 • 1,009 citations

NMDA receptor hypofunction model of schizophrenia

1999 • 1,007 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

2000 • 781 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives

1998 • 468 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Hippocampal Pathologic Findings in Schizophrenia

1989 • 437 citations

A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia

1998 • 408 citations

Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration

1996 • 402 citations

Immunocytochemical localization of GABA-, cholecystokinin-, vasoactive intestinal polypeptide-, and somatostatin-like immunoreactivity in the area dentata and hippocampus of the rat

1987 • 398 citations

Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method

1998 • 394 citations

Cholinesterase Inhibitors: A New Class of Psychotropic Compounds

2000 • 384 citations

Effect of smoking history on [3H]nicotine binding in human postmortem brain.

1997 • 382 citations

Acetylcholine Activates an α-Bungarotoxin-Sensitive Nicotinic Current in Rat Hippocampal Interneurons, But Not Pyramidal Cells

1998 • 380 citations

Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia

2000 • 340 citations

Neurotransmitter interactions in schizophrenia—therapeutic implications

1999 • 305 citations

Decreased Protein Levels of Nicotinic Receptor Subunits in the Hippocampus and Temporal Cortex of Patients with Alzheimer’s Disease

2000 • 283 citations

Decreased protein level of nicotinic receptor α7 subunit in the frontal cortex from schizophrenic brain

1999 • 280 citations

NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees

1998 • 269 citations

Cholinergic gating of response to auditory stimuli in rat hippocampus

1992 • 264 citations

Nicotinic receptors that bind α-bungarotoxin on neurons raise intracellular free ca2+

1992 • 263 citations

Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers

1997 • 252 citations

Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia

1999 • 252 citations

Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks

2000 • 251 citations

Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)

1998 • 239 citations

Nicotinic Receptor-Induced Apoptotic Cell Death of Hippocampal Progenitor Cells

1998 • 234 citations

Comparison of the regional expression of nicotinic acetylcholine receptor ?7 mRNA and [125I]-?-bungarotoxin binding in human postmortem brain

1997 • 233 citations

Schizophrenia and Nicotinic Receptors

1994 • 224 citations

Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for ‘hypofrontality’

1999 • 216 citations

Neurons in rat hippocampus that synthesize nitric oxide

1993 • 214 citations

Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain

1999 • 214 citations

Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression

1993 • 205 citations

Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia

1990 • 202 citations

α4 but Not α3 and α7 Nicotinic Acetylcholine Receptor Subunits Are Lost from the Temporal Cortex in Alzheimer's Disease

1999 • 197 citations

Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons

1997 • 194 citations

Peptides, the limbic lobe and schizophrenia

1983 • 184 citations

Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients

2000 • 176 citations

UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes

2000 • 165 citations

Synaptic connections of neuropeptide Y (NPY) immunoreactive neurons in the hilar area of the rat hippocampus

1990 • 165 citations

Reduced cholecystokinin-like and somatostatin-like immunoreactivity in limbic lobe is associated with negative symptoms in schizophrenia

1983 • 164 citations

Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord

1998 • 160 citations

Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics

1993 • 157 citations

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated‐tau protein

1999 • 155 citations

Somatostatin-like immunoreactive neurons in the hippocampus: An immunocytochemical study in the rat

1982 • 153 citations

Differences in the subregional and cellular distribution of GABAA receptor binding in the hippocampal formation of schizophrenic brain

1996 • 145 citations

Sensory physiology and catecholamines in schizophrenia and mania

1990 • 141 citations

Mice Homozygous for the L250T Mutation in the α7 Nicotinic Acetylcholine Receptor Show Increased Neuronal Apoptosis and Die Within 1 Day of Birth

2000 • 133 citations

Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative

1998 • 129 citations

Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families

2000 • 127 citations

Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings

1994 • 122 citations

Neurotransmitter interactions in schizophrenia-therapeutic implications

1999 • 110 citations

Seizures and Schizophrenia

1997 • 108 citations

Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat

1998 • 107 citations

Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain

1998 • 96 citations

Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex

1996 • 94 citations

Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia

1999 • 93 citations

Effects of dopamine on spontaneous and evoked activity of caudate neurons

1983 • 82 citations

Prospects for research on schizophrenia. 3. Neurophysiology. Neuropathological findings.

1972 • 81 citations

Various types of non-pyramidal hippocampal neurons project to the septum and contralateral hippocampus

1986 • 80 citations

Impairment of Inhibitory Synaptic Transmission in Mice Lacking Synapsin I

1999 • 80 citations

[125I]α-Bungarotoxin binding marks primary sensory areas of developing rat neocortex

1989 • 73 citations

Cortical cholinergic markers in schizophrenia

1994 • 69 citations

The thalamus and neuropsychiatric illness

1997 • 66 citations

No evidence for linkage between schizophrenia and markers at chromosome 15q13-14

1999 • 66 citations

Brief research communication: No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families

1998 • 64 citations

Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus

1993 • 63 citations

The relationship of α-bungarotoxin binding activity and cholinergic termination within the rat hippocampus

1979 • 62 citations

Imaging of calcium variations in living dendritic spines of cultured rat hippocampal neurons.

1995 • 59 citations

VASE-Containing N-CAM Isoforms Are Increased in the Hippocampus in Bipolar Disorder but Not Schizophrenia

1998 • 48 citations

Nicotine withdrawal in the rat

1999 • 45 citations

Localization of mRNA for CHRNA7 in human fetal brain.

1999 • 31 citations

`Dormant' inhibitory neurons: do they exist and what is their functional impact?

1998 • 19 citations

Nicotinic antagonist α-bungarotoxin binding to rat hippocampal neurons containing nitric oxide synthase

1997 • 18 citations

Afferent fibers from the septum terminate on gamma-aminobutyric acid (GABA-) interneurons and granule cells in the area dentata of the rat

1986 • 14 citations

228. A genome scan using a pharmacogenetic approach indicates a susceptibility locus for BD on 15q14

2000 • 12 citations