Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

The origins of intelligence in children.

1952 • 9,556 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Dementia Praecox or the Group of Schizophrenias

1951 • 4,409 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

Negative Symptoms in Schizophrenia

1982 • 2,228 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effects of Different Brain Lesions on Card Sorting

1963 • 2,198 citations

The frontal lobes

1986 • 2,138 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Vulnerability: A new view of schizophrenia.

1977 • 1,961 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

The myelogenetic cycles of regional maturation of the brain

1967 • 1,558 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

1986 • 1,126 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

Neuropsychological studies of the frontal lobes.

1984 • 1,037 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

The role of the limbic system in experiential phenomena of temporal lobe epilepsy

1982 • 843 citations

The limbic system

1974 • 751 citations

Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain

1984 • 701 citations

Postmortem Evidence of Structural Brain Changes in Schizophrenia

1986 • 684 citations

A neurohistological correlate of schizophrenia.

1984 • 584 citations

MENTAL PHENOMENA EVOKED BY ELECTRICAL STIMULATION OF THE HUMAN HIPPOCAMPAL FORMATION AND AMYGDALA

1978 • 577 citations

Part III. Speculations on the Processes That Underlie Schizophrenic Symptoms and Signs

1974 • 572 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Positive and Negative Schizophrenic Symptoms and the Role of Dopamine

1980 • 544 citations

NEUROPSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS: DIAGNOSIS, CLINICAL SPECTRUM, AND RELATIONSHIP TO OTHER FEATURES OF THE DISEASE

1976 • 531 citations

"Memory of the future": an essay on the temporal organization of conscious awareness.

1985 • 525 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

1986 • 506 citations

Antipsychotic Drugs, Neurotransmitters, and Schizophrenia

1978 • 500 citations

Cell loss in the hippocampus of schizophrenics

1986 • 496 citations

Pharmacology of mesocortical dopamine neurons.

1983 • 478 citations

Neuropathology of Schizophrenia

1982 • 472 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 420 citations

Bimodal Distribution of Dopamine Receptor Densities in Brains of Schizophrenics

1984 • 347 citations

Computed Tomography in Schizophreniform Disorder and Other Acute Psychiatric Disorders

1982 • 326 citations

Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings.

1983 • 324 citations

Neurobiologic Antecedents of Schizophrenia in Children

1977 • 283 citations

Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys

1982 • 283 citations

Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity

1971 • 274 citations

From metapsychology to molecular biology: explorations into the nature of anxiety

1983 • 260 citations

Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia

1980 • 258 citations

Akinesia

1975 • 257 citations

Neurology of hereditary metabolic diseases of children

1997 • 243 citations

Increased Dopamine Receptor Sensitivity After Estrogen Treatment Using the Rat Rotation Model

1980 • 222 citations

Parkinsonism

1975 • 219 citations

A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics.

1983 • 197 citations

Ventricular enlargement in teenage patients with schizophrenia spectrum disorder

1983 • 184 citations

Dopamine deficiency in the cerebral cortex in Parkinson disease

1982 • 179 citations

Schizophrenia with Good and Poor Outcome II: Cerebral Ventricular Size and its Clinical Significance

1985 • 171 citations

Schizophrenia-like psychoses associated with organic cerebral disorders: a review.

1983 • 171 citations

The Evolution of Symptoms in Institutionalized Hebephrenic/Catatonic Schizophrenics

1982 • 168 citations

The diencephalon in schizophrenia: Evidence for reduced thickness of the periventricular grey matter

1984 • 163 citations

Day Treatment and Psychotropic Drugs in the Aftercare of Schizophrenic Patients

1979 • 158 citations

Computed tomography of the brain in patients with acute psychosis and in healthy volunteers

1982 • 149 citations

Intellectual changes in patients with MPTP‐induced parkinsonism

1985 • 149 citations

Creutzfeldt‐Jakob disease of long duration: Clinicopathological characteristics, transmissibility, and differential diagnosis

1984 • 142 citations

PSYCHOSES FOLLOWING WAR BRAIN INJURIES

1969 • 142 citations

Computerized tomographic scan changes in early schizophrenia – preliminary findings

1986 • 137 citations

Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: Correlations to symptomatology and family history

1985 • 121 citations

A clinicopathological study of 323 patients with oligodendrogliomas

1986 • 118 citations

Relationship of stress and activity to brain dopamine and homovanillic acid

1971 • 115 citations

The distribution of alterations in energy metabolism in the rat brain produced by apomorphine

1982 • 111 citations

The effect of l-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs

1975 • 111 citations

Neuropsychiatric disturbances associated with idiopathic calcification of the basal ganglia.

1983 • 111 citations

Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142

1985 • 101 citations

Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates

1987 • 93 citations

Biology of Schizophrenia Subtypes: A Review and Proposal for Method of Study

1979 • 91 citations

Day Treatment and Psychotropic Drugs in the Aftercare of Schizophrenic Patients

1980 • 85 citations

Huntington's chorea in Michigan

1960 • 78 citations

Maturation of prefrontal cortex in the monkey revealed by local reversible cryogenic depression

1977 • 77 citations

Differential effects of early and late lesions of frontal granular cortex in the monkey

1967 • 67 citations

Neural Plasticity in Schizophrenia

1985 • 60 citations

Lesions of the Nucleus Ansae Peduncularis in Neuropsychiatric Disease

1981 • 60 citations

LIMBIC EPILEPSY IN CHILDHOOD

1967 • 45 citations

CLINICAL COURSE OF ADULT METACHROMATIC LEUKODYSTROPHY PRESENTING AS SCHIZOPHRENIA A REPORT OF TWO LIVING CASES IN SIBLINGS

1978 • 45 citations

Clinical effect of L-dopa on schizophrenia.

1976 • 32 citations

ENCEPHALITIS AS A CAUSATIVE FACTOR IN BEHAVIOR DISORDERS OF CHILDREN

1948 • 22 citations

Methodological issues in the neuropsychological approach to schizophrenia

1986 • 22 citations

Deleted Work

1955 • 0 citations