Back to search

Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

Data up to Jan 2025

Published2003
Citations368
References72

Total Citations Per Year

Abstract

References (72)

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

1999 • 1,029 citations

Schizophrenics Show Spatial Working Memory Deficits

1992 • 953 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Prefrontal neurons and the genetics of schizophrenia

2001 • 738 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines

2002 • 661 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter

1998 • 578 citations

Neurophysiological correlates of age-related changes in human motor function

2002 • 521 citations

Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain

1995 • 486 citations

Prefrontal function in schizophrenia: confounds and controversies

1996 • 420 citations

Dopaminergic modulation of cortical function in patients with Parkinson's disease

2002 • 403 citations

Cytoarchitectonic Definition of Prefrontal Areas in the Normal Human Cortex: I. Remapping of Areas 9 and 46 using Quantitative Criteria

1995 • 398 citations

Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons

2000 • 394 citations

Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

1999 • 385 citations

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

1999 • 371 citations

Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake2) and Evidence for the Expression of the Transporter in the Brain

1998 • 362 citations

Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization

2001 • 355 citations

3‐Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model

1994 • 349 citations

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

1994 • 332 citations

Human Neurons Express the Polyspecific Cation Transporter hOCT2, Which Translocates Monoamine Neurotransmitters, Amantadine, and Memantine

1998 • 324 citations

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder

1997 • 311 citations

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits

2000 • 243 citations

Dopamine D5 receptors of rat and human brain

2000 • 233 citations

Dendrodendritic Inhibition Through Reversal of Dopamine Transport

2001 • 212 citations

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

1991 • 197 citations

Optimization of cRNA probein situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: A detailed protocol

1990 • 191 citations

High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers

1997 • 181 citations

The “Psychic” Neuron of the Cerebral Cortex

1999 • 180 citations

Word and Tone Working Memory Deficits in Schizophrenia

1998 • 173 citations

Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele

1998 • 171 citations

Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): Association of the high-enzyme activity val allele with adhd impulsive-hyperactive phenotype

1999 • 167 citations

Evoked Extracellular Dopamine In Vivo in the Medial Prefrontal Cortex

1993 • 158 citations

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

2000 • 142 citations

Full-length cDNA cloning and distribution of human dopamine D4 receptor

1995 • 141 citations

Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain

1979 • 139 citations

Cloning, expression and structure of catechol-O-methyltransferase

1995 • 130 citations

Preferential transmission of the high activity allele of COMT in schizophrenia

1996 • 127 citations

Distribution of catechol-O-methyltransferase expression in human central nervous system

1998 • 125 citations

Characterization of Extracellular Dopamine Clearance in the Medial Prefrontal Cortex: Role of Monoamine Uptake and Monoamine Oxidase Inhibition

2001 • 124 citations

Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the O-methylation of the catecholamine neurotransmitters

1992 • 123 citations

Distribution of catechol-O-methyltransferase enzyme in rat tissues.

1994 • 122 citations

Distinct Cellular Localization of Membrane‐Bound and Soluble Forms of Catechol‐O‐Methyltransferase in Brain

1983 • 111 citations

Structure of the human brain

1976 • 110 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

Expression and Intracellular Localization of Catechol O‐methyltransferase in Transfected Mammalian Cells

1997 • 103 citations

Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons

2000 • 101 citations

Mesocortical Dopaminergic Function and Human Cognition

1988 • 100 citations

Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase

1982 • 95 citations

Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype

2001 • 92 citations

Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein

1995 • 78 citations

Structure of the Rat Catechol-O-Methyltransferase Gene: Separate Promoters Are Used to Produce mRNAs for Soluble and Membrane-Bound Forms of the Enzyme

1993 • 75 citations

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits

2000 • 66 citations

Striatal membrane-bound and soluble catechol-O-methyl-transferase after selective neuronal lesions in the rat

1987 • 63 citations

A membrane component of the endoplasmic reticulum that may be essential for protein translocation.

1989 • 61 citations

Distribution of catechol-O-methyltransferase, histamine N-methyltransferase and monoamine oxidase in specific areas of the rat brain

1976 • 60 citations

Distribution of dopamine D1 receptors in rat cortical areas, neostriatum, olfactory bulb and hippocampus in relation to endogenous dopamine contents

1988 • 59 citations

Immunohistochemical study of catechol-O-methyltransferase in the human mesostriatal system

1994 • 56 citations

Localization of catechol-O-methyltransferase in the leptomeninges, choroid plexus and ciliary epithelium: implications for the separation of central and peripheral catechols

1981 • 54 citations

Quantification of D1B (D5) receptors in dopamine D1A receptor-deficient mice

2001 • 49 citations

Localization of Membrane‐Bound Catechol‐O‐Methyltransferase

1983 • 43 citations

Cell‐free synthesis of rat and human catechol O‐methyltransferase

1991 • 41 citations

Unique and Cell-Type-Specific Tyrosine Hydroxylase Gene Expression

1997 • 11 citations

Catechol-O-methyltransferase (COMT)

2024 • 8 citations

Cited By (0)

No citing papers found in database

Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role… (2003) – Neuroscience | Metascience Observatory Explorer