Back signaling by the Nrg-1 intracellular domain

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Neuregulin and ErbB receptor signaling pathways in the nervous system

2001 • 490 citations

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice

1997 • 462 citations

The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

2001 • 439 citations

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

2000 • 418 citations

Isoform-specific expression and function of neuregulin

1997 • 384 citations

Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction

2001 • 382 citations

Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

2001 • 342 citations

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

1998 • 334 citations

Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses

2000 • 309 citations

Presenilin-dependent γ-Secretase-like Intramembrane Cleavage of ErbB4

2002 • 285 citations

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

2002 • 265 citations

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

1996 • 228 citations

LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics

2002 • 197 citations

A RIP Tide in Neuronal Signal Transduction

2002 • 162 citations

Differential Shedding of Transmembrane Neuregulin Isoforms by the Tumor Necrosis Factor-α-Converting Enzyme

2000 • 159 citations

A Cysteine-Rich Isoform of Neuregulin Controls the Level of Expression of Neuronal Nicotinic Receptor Channels during Synaptogenesis

1998 • 143 citations

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

2000 • 142 citations

ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network

1998 • 141 citations

Neoplastic Transformation by Notch Requires Nuclear Localization

2000 • 123 citations

The N-terminal Region of Neuregulin Isoforms Determines the Accumulation of Cell Surface and Released Neuregulin Ectodomain

2001 • 123 citations

Signaling Downstream of Eph Receptors and Ephrin Ligands

2001 • 102 citations

Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells

2002 • 94 citations

Transmembrane Neuregulins Interact with LIM Kinase 1, a Cytoplasmic Protein Kinase Implicated in Development of Visuospatial Cognition

1998 • 92 citations

Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail

1998 • 92 citations

Biosynthetic Processing of neu Differentiation Factor

1995 • 89 citations

Neu Differentiation Factor (NDF), a Dominant Oncogene, Causes Apoptosis In Vitro and In Vivo

1998 • 72 citations

The Neuregulin Precursor proARIA Is Processed to ARIA after Expression on the Cell Surface by a Protein Kinase C-Enhanced Mechanism

1998 • 67 citations

Formation of a high affinity heregulin binding site using the soluble extracellular domains of ErbB2 with ErbB3 or ErbB4

1998 • 65 citations

Release of the Neuregulin Functional Polypeptide Requires Its Cytoplasmic Tail

1998 • 61 citations

Nuclear export of LIM-kinase 1, mediated by two leucine-rich nuclear-export signals within the PDZ domain

1999 • 51 citations

Post-translational Processing of Membrane-associated neu Differentiation Factor Proisoforms Expressed in Mammalian Cells

1995 • 43 citations

Involvement of the neuregulins and their receptors in cardiac and neural development

1996 • 39 citations

The oncogene heregulin induces apoptosis in breast epithelial cells and tumors

1998 • 37 citations

An Apoptosis-inducing Isoform of Neu Differentiation Factor (NDF) Identified Using a Novel Screen for Dominant, Apoptosis-inducing Genes

1997 • 36 citations

Neuregulin Signaling via ErbB Receptor Assemblies in the Nervous System

2002 • 33 citations

LIM kinase 1 accumulates in presynaptic terminals during synapse maturation

2000 • 33 citations

The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis.

2000 • 30 citations

Molecular Determinants of the Sensory and Motor Neuron-derived Factor Insertion into Plasma Membrane

2002 • 29 citations

The Transmembrane Heregulin Precursor Is Functionally Active

2001 • 27 citations

Processing of ARIA and release from isolated nerve terminals

1999 • 18 citations