Glutamatergic Mechanisms in Schizophrenia

Cloned Glutamate Receptors

1994 • 3,989 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia

1999 • 1,063 citations

The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs

1954 • 1,014 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

The current status of the dopamine hypothesis of schizophrenia

1988 • 962 citations

The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia

2001 • 915 citations

Schizophrenia genesis: the origins of madness

1991 • 876 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Catching Up on Schizophrenia

2000 • 815 citations

MRI anatomy of schizophrenia

1999 • 735 citations

Increased dopamine transmission in schizophrenia: relationship to illness phases

1999 • 713 citations

The Role of Locus Coeruleus in the Regulation of Cognitive Performance

1999 • 707 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

1994 • 699 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

1993 • 565 citations

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

1996 • 558 citations

Increased cortical kynurenate content in schizophrenia

2001 • 558 citations

D-serine added to antipsychotics for the treatment of schizophrenia

1998 • 557 citations

D2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic Patients

1990 • 526 citations

Projections of the median raphe nucleus in the rat

1999 • 515 citations

Purification of serine racemase: Biosynthesis of the neuromodulator <scp>d</scp> -serine

1999 • 501 citations

Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

1998 • 493 citations

Efficacy of High-Dose Glycine in the Treatment of Enduring Negative Symptoms of Schizophrenia

1999 • 484 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

1996 • 440 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia

1999 • 435 citations

N -Acetylaspartate in neuropsychiatric disorders

1995 • 422 citations

Excitotoxic Amino Acids and Neuropsychiatric Disorders

1990 • 407 citations

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1997 • 393 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

1999 • 383 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

Ligand affinities at recombinant receptors depend on subunit composition

1994 • 381 citations

Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia

2000 • 374 citations

Ionotropic Glutamate Receptors and Expression ofN-Methyl-<scp>d</scp>-Aspartate Receptor Subunits in Subregions of Human Hippocampus: Effects of Schizophrenia

2000 • 366 citations

Amelioration of negative symptoms in schizophrenia by glycine

1994 • 349 citations

Schizophrenia – a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder

1995 • 345 citations

Comparison of Ketamine-Induced Thought Disorder in Healthy Volunteers and Thought Disorder in Schizophrenia

1999 • 339 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

THE VARIABILITY OF CENTRAL NEURAL ACTIVITY IN A SENSORY SYSTEM, AND ITS IMPLICATIONS FOR THE CENTRAL REFLECTION OF SENSORY EVENTS

1963 • 297 citations

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

1979 • 263 citations

Double-Blind, Placebo-Controlled, Crossover Trial of Glycine Adjuvant Therapy for Treatment-Resistant Schizophrenia

1996 • 253 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

Smoking, nicotine and human performance

1983 • 245 citations

Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization

1981 • 242 citations

Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia

1995 • 238 citations

Biochemical evidence for γ-aminobutyrate containing fibres from the nucleus accumbens to the substantia nigra and ventral tegmental area in the rat

1980 • 232 citations

NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders

1999 • 230 citations

Ionotropic Glutamate Receptor Binding and Subunit mRNA Expression in Thalamic Nuclei in Schizophrenia

2000 • 227 citations

<scp>d-</scp>Serine Added to Clozapine for the Treatment of Schizophrenia

1999 • 224 citations

Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to <scp>l</scp>‐Kynurenine

1989 • 221 citations

Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: microiontophoretic studies.

1984 • 220 citations

Identification and quantification of kynurenic acid in human brain tissue

1988 • 217 citations

Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans

2000 • 217 citations

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia

1995 • 213 citations

Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors.

1997 • 210 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia

1983 • 201 citations

Glutamate Modulation of Dopamine Measured in Vivo with Positron Emission Tomography (PET) and 11C-Raclopride in Normal Human Subjects

1998 • 199 citations

Clozapine Blunts N-Methyl-d-Aspartate Antagonist-Induced Psychosis: A Study with Ketamine

1997 • 197 citations

D-cycloserine added to clozapine for patients with schizophrenia

1996 • 184 citations

Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia

1995 • 181 citations

Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions

2000 • 178 citations

The Nagging Question of the Function ofN-Acetylaspartylglutamate

1997 • 173 citations

New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine

1995 • 173 citations

Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release.

1999 • 172 citations

d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes

1990 • 168 citations

Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons

1980 • 165 citations

Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia

1997 • 158 citations

The pharmacology of mesocortical dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and prefrontal cortex of the rat brain.

1998 • 151 citations

Specific Relationship Between Prefrontal NeuronalN-Acetylaspartate and Activation of the Working Memory Cortical Network in Schizophrenia

2000 • 151 citations

Cognitive function in schizophrenia

1997 • 138 citations

Proposal for a noradrenaline hypothesis of schizophrenia

2004 • 134 citations

Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers

1995 • 133 citations

Comparison of Phencyclidine Hydrochloride (Sernyl) with Other Drugs

1962 • 128 citations

Search for schizophrenia susceptibility genes

2000 • 125 citations

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

1994 • 114 citations

D2-Family receptor distribution in human postmortem tissue

1995 • 104 citations

Efficacy and tolerance of D-cycloserine in drug-free schizophrenic patients

1996 • 104 citations

Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia

1997 • 100 citations

Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex

1994 • 99 citations

Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity

1993 • 98 citations

Dopamine and norepinephrine activity in schizophrenia

1991 • 97 citations

Preliminary investigation of high-dose oral glycine on serum levels and negative symptoms in schizophrenia: an open-label trial

1996 • 91 citations

Synapse structure: Glutamate receptors connected by the shanks

1999 • 91 citations

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

1995 • 90 citations

d-Cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label study

1994 • 88 citations

Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat

1994 • 88 citations

D-Cycloserine Increases Positive Symptoms in Chronic Schizophrenic Patients When Administered in Addition to Antipsychotics A Double-Blind, Parallel, Placebo-Controlled Study

1999 • 84 citations

Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia

1998 • 83 citations

Synergistic interactions between ampakines and antipsychotic drugs.

1999 • 82 citations

Abnormal Kainate Receptor Expression in Prefrontal Cortex in Schizophrenia

2001 • 81 citations

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo

2000 • 78 citations

Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel.

1994 • 74 citations

Glutamatergic neurotransmission involves structural and clinical deficits of schizophrenia

1998 • 74 citations

Localization of GABAB receptors in midbrain monoamine containing neurons in the rat

2001 • 71 citations

Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens

1980 • 71 citations

Phencyclidine poisoning in young children

1980 • 70 citations

Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse

1997 • 70 citations

The effects of early and sustained intervention on the long-term morbidity of schizophrenia

1998 • 70 citations

BRAIN IMAGING IN SCHIZOPHRENIA

1995 • 68 citations

FOUR CASES OF TUBERCULAR MENINGITIS IN WHICH PARACENTESIS OF THE THECA VERTEBRALIS WAS PERFORMED FOR THE RELIEF OF FLUID PRESSURE.

1891 • 67 citations

Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons

1980 • 64 citations

Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists

1993 • 61 citations

Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain

1999 • 56 citations

D-Cycloserine Adjuvant Therapy to Molindone in the Treatment of Schizophrenia

1996 • 54 citations

Correlations between height of subject and concentrations of monoamine metabolites in cerebrospinal fluid from psychotic men and women.

1978 • 54 citations

Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain

1996 • 48 citations

Effects of phencyclidine, MK-801 and 1,3-di(2-tolyl) guanidine on non-dopaminergic midbrain neurons

1993 • 47 citations

Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems

1996 • 45 citations

CSF levels of HVA and 5-HIAA in drug-free schizophrenic patients and healthy controls: a prospective study focused on their predictive value for outcome in schizophrenia

1998 • 42 citations

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

1996 • 41 citations

Dr. Goff Replies

1995 • 37 citations

Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients.

1998 • 37 citations

Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats

1992 • 33 citations

Presynaptic inhibition preferentially reduces the NMDA receptor‐mediated component of transmission in rat midbrain dopamine neurons

1999 • 31 citations

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

1999 • 22 citations