Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Stress, Adaptation, and Disease: Allostasis and Allostatic Load

1998 • 4,336 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

The neuropathology of schizophrenia

1999 • 1,664 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Hippocampal damage associated with prolonged glucocorticoid exposure in primates

1990 • 1,092 citations

Does stress damage the brain?

1999 • 694 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

Longitudinal study of brain morphology in first episode schizophrenia

2001 • 558 citations

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

1998 • 542 citations

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

1997 • 517 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Is schizophrenia a neurodegenerative disorder? a clinical and neurobiological perspective

1999 • 476 citations

The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave

2000 • 470 citations

A Review of Longitudinal Studies of Cognitive Functions in Schizophrenia Patients

1998 • 451 citations

Longitudinal Changes in Magnetic Resonance Imaging Brain Volumes in Abstinent and Relapsed Alcoholics

1995 • 426 citations

Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men

2001 • 417 citations

Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism

1998 • 413 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method

1998 • 394 citations

Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits

2001 • 328 citations

Cell biology of the hippocampal formation in schizophrenia

1999 • 324 citations

Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy

1999 • 278 citations

Atrophy of mesial structures in patients with temporal lobe epilepsy: Cause or consequence of repeated seizures?

1993 • 271 citations

A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings

1995 • 263 citations

Decrease in Thalamic Volumes of Pediatric Patients With Obsessive-compulsive Disorder Who Are Taking Paroxetine

2000 • 261 citations

Change in Basal Ganglia Volume Over 2 Years in Patients With Schizophrenia: Typical Versus Atypical Neuroleptics

1999 • 259 citations

Neuronal Vacuolization and Necrosis Induced by the Noncompetitive N-methyl-d-aspartate (NMDA) Antagonist MK(+)801 (Dizocilpine Maleate): A Light and Electron Microscopic Evaluation of the Rat Retrosplenial Cortex

1993 • 257 citations

Childhood-Onset Schizophrenia

1997 • 250 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Apoptosis in the aging process

2000 • 204 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study.

1988 • 201 citations

Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia

1998 • 200 citations

Progressive Reduction of Temporal Lobe Structures in Childhood-Onset Schizophrenia

1998 • 186 citations

Apoptosis and Alzheimer's disease

2000 • 185 citations

Cortical Bcl-2 protein expression and apoptotic regulation in schizophrenia

2000 • 163 citations

Detection of Subtle Brain Changes Using Subvoxel Registration and Subtraction of Serial MR Images

1995 • 159 citations

Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?

1997 • 152 citations

Critical analysis of the use of computer‐assisted transverse axial tomography to study human brain in aging and dementia of the Alzheimer type

1990 • 147 citations

Enhanced seizures and hippocampal neurodegeneration following kainic acid‐induced seizures in metallothionein‐I + II‐deficient mice

2000 • 136 citations

DNA fragmentation in rat brain after intraperitoneal administration of kainate

1994 • 136 citations

Brain morphology in schizophrenia: a 2‐ to 5‐year CT scan follow‐up study

1988 • 132 citations

Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders

2001 • 125 citations

The Effect of Clozapine on Caudate Nucleus Volume in Schizophrenic Patients Previously Treated with Typical Antipsychotics

2001 • 124 citations

Hippocampus in Alzheimer’s disease: a 3-year follow-up MRI study

2000 • 124 citations

Progression of cerebroventricular enlargement and the subtyping of schizophrenia

1997 • 118 citations

Reversible brain shrinkage in abstinent alcoholics, measured by MRI

1988 • 116 citations

Kainate-induced genes in the hippocampus: lessons from expression patterns

2001 • 111 citations

Quantitative MRI hippocampal volumes: association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients

1993 • 111 citations

Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study

1994 • 101 citations

Reversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional grid

1996 • 86 citations

Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study

1989 • 83 citations

A prospective cohort study of neurodevelopmental processes in the genesis and epigenesis of schizophrenia

1999 • 83 citations

Association of brain structural change with the heterogeneous course of schizophrenia from early childhood through five years subsequent to a first hospitalization

1998 • 81 citations

Brain atrophy and neuronal loss in alcoholism: a role for DNA damage?

2000 • 65 citations

Stability of cerebral ventricular size from the appearance of the first psychotic symptoms to the later diagnosis of schizophrenia

1994 • 63 citations

N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease

2000 • 61 citations

Apparent Cerebral Atrophy in Patients on Treatment with Steroids

1980 • 50 citations

Brain and ventricle instability during psychotic episodes of the schizophrenias

2000 • 47 citations

Schizophrenia as a progressive disorder: Relations to EEG, CT. neuropathological and other evidence

1989 • 45 citations

Apoptosis and gene expression: Perspectives on alcohol-induced brain damage

1994 • 45 citations

Three-year follow-up of older schizophrenics: Extrapyramidal syndromes, psychiatric symptoms, and ventricular brain ratio

1991 • 40 citations

Left ventricular enlargement associated with diagnostic outcome of schizophreniform disorder

1992 • 36 citations

Reactive gliosis of immature Bergmann glia and microglial cell activation in response to cell death of granule cell precursors induced by methylazoxymethanol treatment in developing rat cerebellum

1998 • 36 citations

The Identification of Cerebral Volume Changes in Treated Growth Hormone-Deficient Adults Using Serial 3D MR Image Processing

2000 • 28 citations