Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Regional differences in synaptogenesis in human cerebral cortex

1997 • 2,944 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

The neuropathology of schizophrenia

1999 • 1,664 citations

Meta-Analysis of Regional Brain Volumes in Schizophrenia

2000 • 1,657 citations

The neuropsychology of schizophrenia

1991 • 1,376 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

Schizophrenia: a disconnection syndrome?

1995 • 1,310 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Neuropsychological Deficits in Neuroleptic Naive Patients With First-Episode Schizophrenia

1994 • 1,099 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

2001 • 754 citations

Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging

1998 • 753 citations

Myelination of a Key Relay Zone in the Hippocampal Formation Occurs in the Human Brain During Childhood, Adolescence, and Adulthood

1994 • 740 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity

2000 • 647 citations

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

2000 • 640 citations

A Unitary Model of Schizophrenia

1999 • 605 citations

The left striato-pallidal hyperactivity model of schizophrenia

1994 • 600 citations

A neurohistological correlate of schizophrenia.

1984 • 584 citations

From neuropathology to neurodevelopment

1995 • 569 citations

Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness

1994 • 548 citations

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

1992 • 546 citations

Chronic stress alters synaptic terminal structure in hippocampus

1997 • 539 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

Emerging principles of altered neural circuitry in schizophrenia

2000 • 520 citations

Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia

1991 • 517 citations

Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

1994 • 507 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

1986 • 506 citations

Cell loss in the hippocampus of schizophrenics

1986 • 496 citations

Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

1998 • 493 citations

A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives

1998 • 468 citations

Hippocampal Pathologic Findings in Schizophrenia

1989 • 437 citations

Synaptic Vesicle Size and Number Are Regulated by a Clathrin Adaptor Protein Required for Endocytosis

1998 • 426 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats

2000 • 389 citations

Structural Correlates of Cognition in Dementia: Quantification and Assessment of Synapse Change

1996 • 387 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Hippocampal Volume in First-Episode Psychoses and Chronic Schizophrenia

1999 • 364 citations

Structural Abnormalities of Subicular Dendrites in Subjects With Schizophrenia and Mood Disorders

2000 • 357 citations

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

1989 • 353 citations

The Localization of the Brain-Specific Inorganic Phosphate Transporter Suggests a Specific Presynaptic Role in Glutamatergic Transmission

1998 • 326 citations

Cell biology of the hippocampal formation in schizophrenia

1999 • 324 citations

Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions

1995 • 319 citations

Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients

1991 • 276 citations

Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses.

1996 • 265 citations

THE LEFT MEDIAL TEMPORAL REGION AND SCHIZOPHRENIA: A PET STUDY

1992 • 264 citations

Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections.

1990 • 263 citations

Structural Synaptic Modifications Associated with Hippocampal LTP and Behavioral Learning

2000 • 261 citations

Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins

2001 • 260 citations

Decreased Somal Size of Deep Layer 3 Pyramidal Neurons in the Prefrontal Cortex of Subjects With Schizophrenia

2001 • 256 citations

Spine loss and other dendritic abnormalities in epilepsy

2000 • 252 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

Hippocampal Pyramidal Cell Disarray in Schizophrenia as a Bilateral Phenomenon

1991 • 239 citations

Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.

1991 • 234 citations

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

2005 • 232 citations

Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia

1995 • 216 citations

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia

1995 • 213 citations

Hippocampal Pyramidal Cell Orientation in Schizophrenia

1987 • 210 citations

Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat

1991 • 207 citations

Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features

1996 • 206 citations

Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study

1998 • 203 citations

Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia

1998 • 200 citations

The morphology of synapses

1996 • 199 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

1999 • 195 citations

Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography

1995 • 195 citations

Hippocampal Neuron Number in Schizophrenia

1991 • 188 citations

Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus

1999 • 186 citations

A Quantitative Investigation of Hippocampal Pyramidal Cell Size, Shape, and Variability of Orientation in Schizophrenia

1989 • 177 citations

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

1997 • 176 citations

SNAP-25 deficit and hippocampal connectivity in schizophrenia

1998 • 172 citations

Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs

2000 • 171 citations

Dementia with Lewy Bodies Versus Pure Alzheimer Disease

1997 • 165 citations

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1994 • 160 citations

Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia

1997 • 158 citations

Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics

1993 • 157 citations

Early and late environmental risk factors for schizophrenia

2000 • 156 citations

Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy

2000 • 149 citations

The neuropathological effects of antipsychotic drugs

1999 • 142 citations

The Role of Synaptic Proteins in the Pathogenesis of Disorders of the Central Nervous System

1993 • 140 citations

Abnormal Reinnervation as a Basis for Schizophrenia: A Hypothesis

1992 • 137 citations

Schizophrenia: a disorder of neurodevelopment?

1997 • 134 citations

Control of spine formation by electrical activity in the adult rat cerebellum

1999 • 122 citations

Entorhinal cortex pre-alpha cell clusters in schizophrenia: quantitative evidence of a developmental abnormality

2000 • 121 citations

Age-changes of brain synapses and synaptic plasticity in response to an enriched environment

1999 • 115 citations

Cerebellar synaptic protein expression in schizophrenia

2001 • 113 citations

Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses

1995 • 110 citations

Developmental and plasticity-related differential expression of two SNAP-25 isoforms in the rat brain

1996 • 107 citations

Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways

1996 • 107 citations

Glutamate decarboxylase65-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain

2000 • 106 citations

Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia

1995 • 104 citations

The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains

1999 • 103 citations

A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia

1997 • 101 citations

Synaptophysin gene expression in schizophrenia

2000 • 101 citations

Hippocampal connectivity and Alzheimer's dementia

1994 • 100 citations

Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain

1998 • 96 citations

Cytoarchitecture of the entorhinal cortex in schizophrenia

1997 • 94 citations

Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia

1999 • 93 citations

Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study

1994 • 93 citations

Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats

1999 • 90 citations

Lamina-Specific Synaptic Activation Causes Domain-Specific Alterations in Dendritic Immunostaining for MAP2 and CAM Kinase II

1999 • 90 citations

Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia1This study was presented at the 27th Meeting of the Society for Neuroscience (New Orleans 1997).1

1998 • 89 citations

Decreased density of tyrosine hydroxylase–immunoreactive axons in the entorhinal cortex of schizophrenic subjects

2000 • 88 citations

Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients

1997 • 82 citations

Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex

2001 • 80 citations

The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry

1997 • 77 citations

Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia

1998 • 73 citations

Golgi preparations as a tool in neuropathology with particular reference to investigations of the human telencephalic cortex

1985 • 72 citations

Synapsin I and syntaxin 1B: Key elements in the control of neurotransmitter release are regulated by neuronal activation and long-term potentiation in vivo

1997 • 70 citations

Synaptic Pathology in Borna Disease Virus Persistent Infection

2000 • 70 citations

Hippocampal microtubule-associated protein-2 alterations with contextual memory1Published on the World Wide Web on 28 January 1999.1

1999 • 69 citations

Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt–Jakob disease

2000 • 67 citations

Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia

2001 • 66 citations

Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes

1997 • 66 citations

The medial temporal lobe in schizophrenia

1997 • 66 citations

On the Neuropathology of Schizophrenia and its Dementia: Neurodevelopmental, Neurodegenerative, or Both?

1995 • 62 citations

Neurodevelopment and Adult Psychopathology

1998 • 62 citations

Postmortem changes in the levels and localization of microtubule‐associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus

1994 • 62 citations

Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections

1999 • 60 citations

Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia

1998 • 57 citations

Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 55 citations

Increased dendritic MAP2 expression in the hippocampus in schizophrenia

2000 • 55 citations

The Growth-Associated Protein GAP-43 Is Increased in the Hippocampus and in the Gyrus Cinguli in Schizophrenia

1999 • 51 citations

Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia

1997 • 50 citations

Alterations in hippocampal mossy fiber pathway in Schizophrenia and Alzheimer' s disease

1995 • 49 citations

Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain

2000 • 49 citations

Medium-sized neurofilament protein related to maturation of a subset of cortical neurons

1999 • 49 citations

Differential expression of synaptosome-associated protein 25 kDa [SNAP-25] in hippocampi of neonatal mice following exposure to human influenza virus in utero

1998 • 48 citations

Increased synapsin I immunoreactivity during long-term potentiation in rat hippocampus

2000 • 46 citations

Quantitative Study of Synaptophysin Immunoreactivity of Cerebral Cortex and Spinal Cord in Motor Neuron Disease

1995 • 45 citations

Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock

1998 • 37 citations

Expression of synaptophysin in sprouting neurons after entorhinal lesion in the rat

1997 • 35 citations

Decreased hippocampal (CA3) NMDA receptors in schizophrenia

1999 • 34 citations

Temporal lobe epilepsy with and without psychosis: exploration of hippocampal pathology including that in subpopulations of neurons defined by their content of immunoreactive calcium-binding proteins

2000 • 32 citations

Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment

1995 • 24 citations

Hippocampal synaptic pathology in patients with temporal lobe epilepsy

1994 • 21 citations

The subiculum: a potential site of action for novel antipsychotic drugs?

1996 • 20 citations

Regional zinc staining in postmortem hippocampus from schizophrenic patients

1995 • 20 citations

The subiculum: a potential site of action for novel antipsychotic drugs?

1996 • 20 citations

Differential Regulation of Synaptic Vesicle Protein Genes by Target and Synaptic Activity

1998 • 18 citations

Synaptophysin immunoreactivity in temporal lobe epilepsy-associated hippocampal sclerosis

1999 • 18 citations

Brief Communication: Correlation of Neuronal Cell Body Size in Motor Cortex and Hippocampus with Body Height, Body Weight, and Axonal Length

1992 • 13 citations

Methodological Issues

2000 • 13 citations

Gliosis and its Implications for the Disease Process

2000 • 12 citations

Synaptic Pathology

2000 • 11 citations

Perspectives from other Diseases and Lesions

2000 • 7 citations

Hippocampal Pathology

2000 • 6 citations