The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

Signaling to NF-κB

2004 • 3,768 citations

The MAPK signaling cascade

1995 • 3,300 citations

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

2004 • 2,381 citations

AP-1: a double-edged sword in tumorigenesis

2003 • 2,077 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Phosphorylation and Functional Inactivation of TSC2 by Erk

2005 • 1,229 citations

The RAF proteins take centre stage

2004 • 1,158 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

2003 • 766 citations

MAP Kinases

2001 • 759 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Regulation of Raf-1 by Direct Feedback Phosphorylation

2005 • 602 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

Paxillin: Adapting to Change

2004 • 582 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1

2000 • 543 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi

2000 • 517 citations

Vimentin-Dependent Spatial Translocation of an Activated MAP Kinase in Injured Nerve

2005 • 505 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

2003 • 463 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

2000 • 444 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

2002 • 417 citations

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 ^MAPK -Dependent Phosphorylation

1999 • 414 citations

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

1996 • 390 citations

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

2002 • 386 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

1996 • 381 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

1998 • 359 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

1996 • 326 citations

Ets ternary complex transcription factors

2003 • 325 citations

A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration

2003 • 324 citations

mTOR, translational control and human disease

2005 • 321 citations

A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1

1998 • 319 citations

Molecular recognitions in the MAP kinase cascades

2003 • 311 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

2000 • 302 citations

MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

2004 • 302 citations

Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases

2002 • 293 citations

Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP

2004 • 292 citations

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1998 • 287 citations

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

2001 • 286 citations

Erk1/2-dependent Phosphorylation of Gα-interacting Protein Stimulates Its GTPase Accelerating Activity and Autophagy in Human Colon Cancer Cells

2000 • 286 citations

Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling

2004 • 280 citations

Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

2004 • 279 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

2003 • 270 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation

2004 • 265 citations

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

1999 • 263 citations

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

1992 • 263 citations

Phosphorylation of Steroid Receptor Coactivator-1

2000 • 260 citations

Isotype-Specific Functions of Raf Kinases

1999 • 259 citations

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

1998 • 257 citations

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

1988 • 257 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

In pursuit of myosin function.

1989 • 252 citations

ERK-Dependent Phosphorylation of the Transcription Initiation Factor TIF-IA Is Required for RNA Polymerase I Transcription and Cell Growth

2003 • 249 citations

Identification of Novel MAP Kinase Pathway Signaling Targets by Functional Proteomics and Mass Spectrometry

2000 • 246 citations

Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.

1990 • 245 citations

The A‐Type Potassium Channel Kv4.2 Is a Substrate for the Mitogen‐Activated Protein Kinase ERK

2000 • 243 citations

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

1992 • 242 citations

An Immediate Response of Ribosomal Transcription to Growth Factor Stimulation in Mammals Is Mediated by ERK Phosphorylation of UBF

2001 • 240 citations

KSR: a MAPK scaffold of the Ras pathway?

2001 • 234 citations

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

2000 • 234 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

Paxillin Serves as an ERK-Regulated Scaffold for Coordinating FAK and Rac Activation in Epithelial Morphogenesis

2004 • 227 citations

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38

2002 • 226 citations

Regulation of carbamoyl phosphate synthetase by MAP kinase

2000 • 220 citations

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

2004 • 219 citations

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

2000 • 216 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

1991 • 215 citations

Phosphorylation-Dependent Paxillin-ERK Association Mediates Hepatocyte Growth Factor-Stimulated Epithelial Morphogenesis

2003 • 214 citations

Bidirectional signals transduced by DAPK?ERK interaction promote the apoptotic effect of DAPK

2004 • 209 citations

Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression

1999 • 205 citations

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

1993 • 205 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Sp1 Phosphorylation by Erk 2 Stimulates DNA Binding

1999 • 201 citations

AKT/PKB signaling mechanisms in cancer and chemoresistance

2005 • 199 citations

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

1997 • 199 citations

MAP Kinase-Dependent Transcriptional Coactivation by Elk-1 and Its Cofactor CBP

1996 • 196 citations

Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

2003 • 186 citations

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1995 • 184 citations

Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases

1999 • 183 citations

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

1997 • 183 citations

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade

1997 • 181 citations

Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities

2003 • 180 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

1999 • 179 citations

Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation

2002 • 177 citations

Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

1993 • 174 citations

Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF

2001 • 174 citations

Untying the regulation of the Raf-1 kinase

2002 • 174 citations

MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase

1997 • 173 citations

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

1994 • 165 citations

Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

2000 • 165 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

2004 • 158 citations

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

1994 • 154 citations

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

1996 • 153 citations

Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases

2005 • 149 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association

2002 • 143 citations

Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1

2002 • 143 citations

Identification of a Cytoplasmic-Retention Sequence in ERK2

1999 • 136 citations

Identification of mitogen‐activated protein kinase phosphorylation sequences in mammalian h‐Caldesmon

1993 • 136 citations

Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation

2005 • 130 citations

Interactions of β and γENaC with Nedd4 Can Be Facilitated by an ERK-mediated Phosphorylation

2002 • 129 citations

Phosphorylation of Tristetraprolin, a Potential Zinc Finger Transcription Factor, by Mitogen Stimulation in Intact Cells and by Mitogen-activated Protein Kinase in Vitro

1995 • 129 citations

Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase

1993 • 128 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

1991 • 126 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

Phosphorylation of αB-crystallin in Mitotic Cells and Identification of Enzymatic Activities Responsible for Phosphorylation

1998 • 124 citations

Protein–Protein Interactions in the Regulation of the Extracellular Signal-Regulated Kinase

2005 • 122 citations

Transactivation of Fra-1 and Consequent Activation of AP-1 Occur Extracellular Signal-Regulated Kinase Dependently

2002 • 121 citations

Analysis of the ERK-Stimulated ETS Transcription Factor ER81

1996 • 121 citations

Identification of Novel ERK2 Substrates through Use of an Engineered Kinase and ATP Analogs

2003 • 120 citations

The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB

2003 • 117 citations

Counting on mitogen-activated protein kinases—ERKs 3, 4, 5, 6, 7 and 8

2004 • 116 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK

2001 • 113 citations

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes

1999 • 112 citations

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

2003 • 111 citations

Mitotic Phosphorylation of Golgi Reassembly Stacking Protein 55 by Mitogen-activated Protein Kinase ERK2

2001 • 111 citations

Phosphorylation of Nuclear Phospholipase C β1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I

2001 • 108 citations

Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

1999 • 108 citations

MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase

1998 • 105 citations

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a

1999 • 104 citations

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

1992 • 104 citations

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation

2002 • 103 citations

Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate

2002 • 103 citations

Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase

1986 • 102 citations

Phosphorylation of the Transactivation Domain of Pax6 by Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinase

1999 • 100 citations

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

2004 • 100 citations

Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910

2003 • 99 citations

ERKs and p38 Kinases Mediate Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10

2000 • 98 citations

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

2002 • 98 citations

Mitogen-activated Protein Kinase Phosphorylates and Regulates the HIV-1 Vif Protein

1998 • 95 citations

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3

2004 • 95 citations

Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2

2004 • 94 citations

DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes

2003 • 94 citations

3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region

1996 • 92 citations

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

2003 • 91 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death

2004 • 88 citations

SAP1a is a nuclear target of signaling cascades involving ERKs.

1995 • 86 citations

Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

2001 • 86 citations

Convergence of Cell Cycle Regulation and Growth Factor Signals on GRASP65

2005 • 80 citations

Identification of the Anti-proliferative Protein Tob as a MAPK Substrate

2002 • 80 citations

Involvement of the Activation Loop of ERK in the Detachment from Cytosolic Anchoring

2001 • 80 citations

Activation mechanism and function of the MAP kinase cascade

1995 • 79 citations

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.

1993 • 78 citations

ERK1b, a 46-kDa ERK Isoform That Is Differentially Regulated by MEK

2000 • 78 citations

Hyaluronan Binding Protein 1 (HABP1)/C1QBP/p32 Is an Endogenous Substrate for MAP Kinase and Is Translocated to the Nucleus upon Mitogenic Stimulation

2002 • 75 citations

ERK Phosphorylates p66shcA on Ser36 and Subsequently Regulates p27^kip1Expression via the Akt-FOXO3a Pathway: Implication of p27^kip1in Cell Response to Oxidative Stress

2005 • 73 citations

Activation of the Hexosamine Pathway Leads to Phosphorylation of Insulin Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Insulin Biosynthetic Pathway in RIN Pancreatic β-Cells

2004 • 72 citations

Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase

2004 • 68 citations

The Recruitment of the Interleukin-1 (IL-1) Receptor-associated Kinase (IRAK) into Focal Adhesion Complexes Is Required for IL-1β-induced ERK Activation

2000 • 68 citations

Scaffold Proteins in Mammalian MAP Kinase Cascades

2004 • 66 citations

Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation

2003 • 65 citations

Adhesion Stimulates Direct PAK1/ERK2 Association and Leads to ERK-dependent PAK1 Thr212 Phosphorylation

2004 • 64 citations

The ERK Cascade As a Prototype of MAPK Signaling Pathways

2004 • 63 citations

Extracellular Signal-Regulated Kinase 1c (ERK1c), a Novel 42-Kilodalton ERK, Demonstrates Unique Modes of Regulation, Localization, and Function

2004 • 63 citations

The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop

2002 • 62 citations

ERK2- and p90Rsk2-dependent Pathways Regulate the CCAAT/Enhancer-binding Protein-β Interaction with Serum Response Factor

2001 • 62 citations

Phosphorylation of Tumor Necrosis Factor Receptor CD120a (p55) by p42 Induces Changes in Its Subcellular Localization

1999 • 60 citations

Extracellular Signal-Regulated Kinase Binds to TFII-I and Regulates Its Activation of the c-fosPromoter

2000 • 59 citations

Phosphorylation of Paxillin via the ERK Mitogen-activated Protein Kinase Cascade in EL4 Thymoma Cells

2000 • 59 citations

Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

2001 • 59 citations

Identification of Major ERK-Related Phosphorylation Sites in Gab1

2004 • 58 citations

Nuclear Receptor and Apoptosis Initiator NGFI-B Is a Substrate for Kinase ERK2

2002 • 58 citations

Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex

2005 • 55 citations

Phosphorylation of Grb2-Associated Binder 2 on Serine 623 by ERK MAPK Regulates Its Association with the Phosphatase SHP-2 and Decreases STAT5 Activation

2004 • 54 citations

Activation of ERK Induces Phosphorylation of MAPK Phosphatase-7, a JNK Specific Phosphatase, at Ser-446

2003 • 54 citations

Phosphorylation of Serine 147 of tis21/BTG2/pc3 by p-Erk1/2 Induces Pin-1 Binding in Cytoplasm and Cell Death

2005 • 53 citations

Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.

1995 • 51 citations

Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase.

1994 • 51 citations

Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5)

2005 • 49 citations

SH2-B, a Membrane-associated Adapter, Is Phosphorylated on Multiple Serines/Threonines in Response to Nerve Growth Factor by Kinases within the MEK/ERK Cascade

1999 • 47 citations

Phosphorylation and Activation of the ATP-Mg-dependent Protein Phosphatase by the Mitogen-activated Protein Kinase

1995 • 47 citations

EGFR and FGFR Signaling through FRS2 Is Subject to Negative Feedback Control by ERK1/2

2003 • 46 citations

Mitogen-activated Protein Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-mediated Destruction

2001 • 46 citations

Extracellular Signal-regulated Kinase Activated by Epidermal Growth Factor and Cell Adhesion Interacts with and Phosphorylates Vinexin

2004 • 44 citations

Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT

2004 • 40 citations

Epidermal Growth Factor Treatment Enhances the Kinase Activity of Kinase Suppressor of Ras

2000 • 39 citations

A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling

2002 • 38 citations

Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation

2004 • 37 citations

Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling.

1999 • 36 citations

Rab4 is phosphorylated by the insulin‐activated extracellular‐signal‐regulated kinase ERK1

1994 • 36 citations

Cutting Edge: Extracellular Signal-Regulated Kinase Activates Syk: A New Potential Feedback Regulation of Fcε Receptor Signaling

1999 • 34 citations

The Molecular Mechanism of MAPK / ERK Inactivation

2004 • 31 citations

Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1

2004 • 31 citations

Regulation of SPIN90 Phosphorylation and Interaction with Nck by ERK and Cell Adhesion

2003 • 28 citations

CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate

1996 • 28 citations

Phosphorylation of annexin XI (CAP-50) in SR-3Y1 cells

1993 • 26 citations

p42 MAPK phosphorylates 80 kDa MARCKS at Ser‐113

1996 • 24 citations

Phosphorylation by MAPK Regulates Simian Immunodeficiency Virus Vpx Protein Nuclear Import and Virus Infectivity

2004 • 22 citations

Identification of Phospholipase C-γ1 as a Mitogen-activated Protein Kinase Substrate

2004 • 21 citations

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2)

2003 • 21 citations

Regulation of Amphiphysin1 by Mitogen-activated Protein Kinase

2004 • 19 citations

Phosphorylation of the carboxyl terminal region of dystrophin by mitogen-activated protein (MAP) kinase

1995 • 18 citations

Phosphorylation of Grb10 by Mitogen-Activated Protein Kinase: Identification of Ser¹⁵⁰ and Ser⁴⁷⁶ of Human Grb10ζ as Major Phosphorylation Sites

2005 • 14 citations

Chromatographic Resolution and Characterization of a Nerve Growth Factor‐Dependent Kinase That Phosphorylates Microtubule‐Associated Proteins 1 and 2 in PC12 Cells

1992 • 10 citations

Phosphorylation of the C-Terminal Domain of RNA Polymerase II by the Extracellular-Signal-Regulated Protein Kinase ERK2

1995 • 10 citations

Transcriptional Repression Activity of N-MYCProtein Requires Phosphorylation by MAP Kinase

1996 • 7 citations