Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma

1985 • 803 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation

1996 • 434 citations

CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment

1997 • 428 citations

CENP-E is a putative kinetochore motor that accumulates just before mitosis

1992 • 424 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.

1987 • 407 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

1991 • 384 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

1997 • 326 citations

MAP Kinase Becomes Stably Activated at Metaphase and Is Associated with Microtubule-Organizing Centers during Meiotic Maturation of Mouse Oocytes

1993 • 300 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

1993 • 264 citations

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.

1992 • 256 citations

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

1995 • 249 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

1993 • 231 citations

CENP‐F is a ca 400 kDa kinetochore protein that exhibits a cell‐cycle dependent localization

1993 • 220 citations

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

1994 • 216 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

1993 • 205 citations

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase

1997 • 176 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein

1994 • 148 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

Chromosomal Proteins and Cytokinesis: Patterns of Cleavage Furrow Formation and Inner Centromere Protein Positioning in Mitotic Heterokaryons and Mid-anaphase Cells

1997 • 141 citations

Characterization of a Novel 350-Kilodalton Nuclear Phosphoprotein That Is Specifically Involved in Mitotic-Phase Progression

1995 • 138 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.

1993 • 121 citations

Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation

1993 • 118 citations

MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts

1997 • 102 citations

A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells

1997 • 100 citations

MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs

1997 • 89 citations

Mitogen-activated protein kinase kinase is required for the mos-induced metaphase arrest.

1994 • 83 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle

1997 • 76 citations

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1993 • 76 citations

Deciphering the MAP kinase pathway

1994 • 66 citations

Activation of the p42 Mitogen-activated Protein Kinase Pathway Inhibits Cdc2 Activation and Entry into M-Phase in CyclingXenopusEgg Extracts

1998 • 61 citations

Induction of a G₂-Phase Arrest inXenopusEgg Extracts by Activation of p42 Mitogen-activated Protein Kinase

1997 • 59 citations

Oncoprotein Signalling and Mitosis

1997 • 42 citations

MPM-2 antibody-reactive phosphorylations can be created in detergentextracted cells by kinetochore-bound and soluble kinases

1997 • 35 citations

Phosphorylation of numa occurs during nuclear breakdown and not mitotic spindle assembly

1995 • 34 citations

Mos oncogene product associates with kinetochores in mammalian somatic cells and disrupts mitotic progression.

1994 • 32 citations

High expression of ras p21 correlates with increased rate of abnormal mitosis in NIH3T3 cells.

1990 • 29 citations

Cell-Cycle-Regulated Localization of Tyrosine and Threonine Phosphoepitopes at the Kinetochores of Mitotic Chromosomes

1995 • 25 citations