Chromatographic Resolution and Characterization of a Nerve Growth Factor‐Dependent Kinase That Phosphorylates Microtubule‐Associated Proteins 1 and 2 in PC12 Cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

1985 • 506 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.

1990 • 245 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.

1990 • 196 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowth.

1986 • 154 citations

Stabilizing basic fibroblast growth factor using protein engineering

1988 • 153 citations

A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation.

1988 • 153 citations

Nerve growth factor regulates both the phosphorylation and steady-state levels of microtubule-associated protein 1.2 (MAP1.2).

1988 • 139 citations

PC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth.

1988 • 133 citations

The role of transcription-dependent priming in nerve growth factor promoted neurite outgrowth

1982 • 130 citations

Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins. Detection, partial purification, and characterization in PC12 cells.

1990 • 116 citations

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation

1990 • 107 citations

Neuritic growth from a new subline of PC12 pheochromocytoma cells: Cyclic AMP mimics the action of nerve growth factor

1987 • 100 citations

Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

1991 • 62 citations

Nerve growth factor stimulates the tyrosine phosphorylation of MAP2 kinase in PC12 cells

1991 • 56 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations

Characterization of a Nerve Growth Factor‐Stimulated Protein Kinase in PC12 Cells Which Phosphorylates Microtubule‐Associated Protein 2 and pp250

1990 • 43 citations

Singing, Speaking, and Stammering

1883 • 6 citations