Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

Maturation promoting factor, cyclin and the control of M-phase

1989 • 260 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.

1991 • 200 citations

Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.

1991 • 188 citations

Xenopus oocytes and the biochemistry of cell division

1990 • 182 citations

Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions.

1991 • 176 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

1988 • 174 citations

Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes.

1990 • 141 citations

The nuclear lamin protein family in higher vertebrates. Identification of quantitatively minor lamin proteins by monoclonal antibodies.

1986 • 134 citations

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro.

1991 • 133 citations

Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte: Antagonistic action of okadaic acid and 6-DMAP

1991 • 128 citations

Protein kinase cascades in meiotic and mitotic cell cycle control

1990 • 124 citations

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

1991 • 118 citations

The substrates of the cdc2 kinase.

1991 • 115 citations

Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization

1988 • 110 citations

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity

1991 • 108 citations

In vivo Phosphorylation and Activation of Ribosomal Protein S6 Kinases during Xenopus Oocyte Maturation

1989 • 102 citations

Characterization of a mitogen‐activated, Ca²⁺‐sensitive microtubule‐associated protein‐2 kinase

1989 • 70 citations

Role of protein phosphorylation in the maturation-induced activation of a myelin basic protein kinase from sea star oocytes.

1991 • 65 citations

p34cdc2 acts as a lamin kinase in fission yeast.

1991 • 61 citations

Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.

1990 • 60 citations

Identification of the sites in myelin basic protein that are phosphorylated by meiosis‐activated protein kinase p44^mpk

1990 • 51 citations

M-phase-specific protein kinase from mitotic sea urchin eggs: Cyclic activation depends on protein synthesis and phosphorylation but does not require DNA or RNA synthesis

1989 • 37 citations

Tyrosyl phosphorylation and activation of the myelin basic protein kinase p44mpk during sea star oocyte maturation

1991 • 29 citations

Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation

1990 • 7 citations