IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.

2001 • 425 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 ^MAPK -Dependent Phosphorylation

1999 • 414 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

1998 • 336 citations

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

2000 • 315 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

2001 • 263 citations

Identification of Novel MAP Kinase Pathway Signaling Targets by Functional Proteomics and Mass Spectrometry

2000 • 246 citations

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

2000 • 244 citations

An Immediate Response of Ribosomal Transcription to Growth Factor Stimulation in Mammals Is Mediated by ERK Phosphorylation of UBF

2001 • 240 citations

Activation of NF-κB by XIAP, the X Chromosome-linked Inhibitor of Apoptosis, in Endothelial Cells Involves TAK1

2000 • 227 citations

Regulation of carbamoyl phosphate synthetase by MAP kinase

2000 • 220 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins

1998 • 211 citations

Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria

1997 • 199 citations

Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

1992 • 166 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast

1998 • 156 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

1997 • 152 citations

Müllerian Inhibiting Substance Inhibits Breast Cancer Cell Growth through an NFκB-mediated Pathway

2000 • 131 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

1994 • 104 citations

Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways

2001 • 97 citations

Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice

2002 • 97 citations

Expression of the NF-κB target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells

2001 • 90 citations

Identification and characterization of a radiation-inducible glycosylated human early-response gene.

1996 • 89 citations

IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes

2001 • 69 citations

PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.

1996 • 54 citations

Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein.

1993 • 51 citations

A Novel Immediate Early Response Gene, IEX-1, Is Induced by Ultraviolet Radiation in Human Keratinocytes

1998 • 49 citations

Respiratory Syncytial Virus Infection Induces Expression of the Anti‐Apoptosis GeneIEX‐1Lin Human Respiratory Epithelial Cells

2000 • 47 citations

The proliferation-associated early response gene p22/PRG1 is a novel p53 target gene

1998 • 45 citations

Cloning and Characterization of a Family of Proteins Associated with Mpl

2002 • 26 citations