mTOR, translational control and human disease

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

The AMP‐Activated Protein Kinase

1997 • 1,313 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

2002 • 1,147 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

2003 • 850 citations

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

2001 • 849 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

2000 • 783 citations

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

2001 • 772 citations

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

2004 • 737 citations

S6K1^−/−/S6K2^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 • 726 citations

Sirolimus: its discovery, biological properties, and mechanism of action

2003 • 717 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

2003 • 644 citations

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

2003 • 580 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

NF1 Tumor Suppressor Gene Function

2001 • 574 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

2002 • 507 citations

TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

2003 • 501 citations

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein

1999 • 490 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

Rheb fills a GAP between TSC and TOR

2003 • 467 citations

Regulation of peptide‐chain elongation in mammalian cells

2002 • 467 citations

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

2001 • 463 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice

2003 • 445 citations

Targeting mTOR signaling for cancer therapy

2003 • 439 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

2003 • 371 citations

Molecular genetic advances in tuberous sclerosis

2000 • 354 citations

FAT: a novel domain in PIK-related kinases

2000 • 300 citations

Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

2001 • 296 citations

Rsk1 mediates a MEK–MAP kinase cell survival signal

2000 • 290 citations

Vascular Abnormalities and Deregulation of VEGF in Lkb1 -Deficient Mice

2001 • 284 citations

mTOR integrates amino acid- and energy-sensing pathways

2003 • 268 citations

A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin

2004 • 252 citations

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

2001 • 251 citations

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1997 • 240 citations

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.

1996 • 217 citations

Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin

2003 • 215 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

2002 • 201 citations

Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast

2002 • 197 citations

SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control

2004 • 192 citations

Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and Proteomics

2002 • 192 citations

Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling

1999 • 186 citations

Lost in translation

2004 • 173 citations

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus

1997 • 165 citations

Peutz-Jeghers Syndrome: A Clinicopathologic Survey of the “Harrisburg Family” With a 49-Year Follow-up

1988 • 159 citations

Analysis of bothTSC1 andTSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis

1999 • 155 citations

Enzymology and biology of CaaX protein prenylation.

1999 • 154 citations

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.

2003 • 153 citations

Ras/Erk Signaling Is Essential for Activation of Protein Synthesis by Gq Protein-Coupled Receptor Agonists in Adult Cardiomyocytes

2002 • 139 citations

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.

1990 • 133 citations

PI3-kinase and TOR: PIKTORing cell growth

2004 • 130 citations

The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake

2000 • 130 citations

Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor

2003 • 125 citations

Drug-Eluting Stents

2004 • 112 citations

Loss of Rhb1, a Rheb-Related GTPase in Fission Yeast, Causes Growth Arrest With a Terminal Phenotype Similar to That Caused by Nitrogen Starvation

2000 • 105 citations

Farnesyltransferase Inhibitors

2001 • 70 citations

TOR: The First 10 Years

2004 • 57 citations

Tuberous sclerosis complex and neurofibromatosis type 1: the two most common neurocutaneous diseases

2002 • 50 citations

Yeast TOR Signaling: A Mechanism for Metabolic Regulation

2004 • 41 citations