Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

1988 • 886 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Molecular cloning and expression of a human heat shock factor, HSF1.

1991 • 472 citations

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

1992 • 464 citations

Multisite and hierarchal protein phosphorylation

1991 • 419 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Direct Evaluation of Electronic Coupling Mediated by Hydrogen Bonds: Implications for Biological Electron Transfer

1995 • 318 citations

Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation

1996 • 294 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Multiple Layers of Regulation of Human Heat Shock Transcription Factor 1

1995 • 246 citations

Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition.

1993 • 223 citations

Transcriptional Repression of the Prointerleukin 1β Gene by Heat Shock Factor 1

1996 • 202 citations

Activation of the DNA-Binding Ability of Human Heat Shock Transcription Factor 1 May Involve the Transition from an Intramolecular to an Intermolecular Triple-Stranded Coiled-Coil Structure

1994 • 198 citations

A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function

1995 • 180 citations

A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor.

1991 • 152 citations

Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins.

1993 • 144 citations

DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells.

1990 • 143 citations

The Regulatory Domain of Human Heat Shock Factor 1 Is Sufficient To Sense Heat Stress

1996 • 137 citations

Ca2+ is essential for multistep activation of the heat shock factor in permeabilized cells.

1991 • 135 citations

[48] cDNA cloning and properties of glycogen synthase kinase-3

1991 • 131 citations

The Carboxyl-Terminal Transactivation Domain of Heat Shock Factor 1 Is Negatively Regulated and Stress Responsive

1995 • 128 citations

[10] Design and use of peptide substrates for protein kinases

1991 • 125 citations

A short element required for turning off heat shock transcription factor: evidence that phosphorylation enhances deactivation.

1994 • 123 citations

Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

1994 • 105 citations

The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor.

1994 • 72 citations

Cis-acting elements involved in the regulated expression of a human hsp70 gene

1988 • 67 citations

Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells.

1995 • 66 citations

Phosphorylation State of the RNA Polymerase II C‐Terminal Domain (CTD) in Heat‐Shocked Cells

1995 • 42 citations