Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

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1996 • 1,330 citations

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1993 • 1,313 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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Ternary complex factors: growth factor regulated transcriptional activators

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Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

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A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

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Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

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Docking domains and substrate-specificity determination for MAP kinases

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

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1999 • 281 citations

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The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

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ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

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A Role for Mitogen-Activated Protein Kinase in Mediating Activation of the Glycoprotein Hormone α-Subunit Promoter by Gonadotropin-Releasing Hormone

1995 • 224 citations

Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression

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ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

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Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

1996 • 164 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

Gain-of-Function Mutations in the Caenorhabditis elegans lin-1 ETS Gene Identify a C-Terminal Regulatory Domain Phosphorylated by ERK MAP Kinase

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1 MAP Kinases in Mitogenesis and Development

1996 • 109 citations

The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo

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Functional gene expression domains: defining the functional unit of eukaryotic gene regulation

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Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

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Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1

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A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 86 citations

Phosphorylation of the Kinase Suppressor of Ras by Associated Kinases

1999 • 35 citations

Dimer Formation by Ternary Complex Factor ELK-1

2000 • 26 citations

Regulation of Dual-specificity Phosphatases M3/6 and hVH5 by Phorbol Esters

2000 • 26 citations