A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 • 796 citations

Dual specificity phosphatases: a gene family for control of MAP kinase function

2000 • 791 citations

MAP Kinases

2001 • 759 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation

1996 • 434 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

2000 • 234 citations

The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases

2002 • 203 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

The Mechanism of Dephosphorylation of Extracellular Signal-regulated Kinase 2 by Mitogen-activated Protein Kinase Phosphatase 3

2001 • 179 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

1999 • 145 citations

Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP)

1999 • 137 citations

Interdependent Domains Controlling the Enzymatic Activity of Mitogen-Activated Protein Kinase Kinase 1

1996 • 134 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

2001 • 113 citations

The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1994 • 106 citations

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

2002 • 98 citations

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

2003 • 97 citations

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

2000 • 96 citations

Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1

2001 • 91 citations

Mechanistic Basis for Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase 3 by Extracellular Signal-regulated Kinase

2000 • 87 citations

Structure-Function Studies of p38 Mitogen-activated Protein Kinase

1997 • 83 citations

Modular Structure of a Docking Surface on MAPK Phosphatases

2002 • 74 citations

PTP-ER, a Novel Tyrosine Phosphatase, Functions Downstream of Ras1 to Downregulate MAP Kinase during Drosophila Eye Development

1999 • 73 citations

Mechanism of Activation of ERK2 by Dual Phosphorylation

2001 • 73 citations

Constitutive Activation of Extracellular Signal-regulated Kinase 2 by Synergistic Point Mutations

2001 • 71 citations

A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.

1994 • 70 citations

Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2

1999 • 65 citations

The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop

2002 • 62 citations

Identification of Two Distinct Regions of p38 MAPK Required for Substrate Binding and Phosphorylation

1999 • 32 citations

Genetic Analysis of rolled, Which Encodes a Drosophila Mitogen-Activated Protein Kinase

1999 • 27 citations

A Kinetic Approach for the Study of Protein Phosphatase-Catalyzed Regulation of Protein Kinase Activity

2002 • 13 citations