The Molecular Mechanism of MAPK / ERK Inactivation

The MAPK signaling cascade

1995 • 3,300 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Dual specificity phosphatases: a gene family for control of MAP kinase function

2000 • 791 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation

1993 • 521 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

2001 • 466 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 ^MAPK -Dependent Phosphorylation

1999 • 414 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and -2 Are Induced by the p42/p44MAPK Cascade

1997 • 358 citations

MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase

1996 • 350 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling

2002 • 312 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

2002 • 268 citations

Regulation of Protein Phosphatase 2A by Direct Interaction with Casein Kinase 2α

1997 • 266 citations

Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

1999 • 264 citations

Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

2001 • 263 citations

cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.

1992 • 234 citations

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

2000 • 216 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5

1999 • 216 citations

p38 Mitogen-Activated Protein Kinase-Dependent Activation of Protein Phosphatases 1 and 2A Inhibits MEK1 and MEK2 Activity and Collagenase 1 (MMP-1) Gene Expression

2001 • 206 citations

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

1999 • 204 citations

The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases

2002 • 203 citations

Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase

1995 • 191 citations

Expression cloning of a human dual-specificity phosphatase.

1992 • 188 citations

The Mechanism of Dephosphorylation of Extracellular Signal-regulated Kinase 2 by Mitogen-activated Protein Kinase Phosphatase 3

2001 • 179 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

Extracellular Regulated Kinases (ERK) 1 and ERK2 Are Authentic Substrates for the Dual-specificity Protein-tyrosine Phosphatase VHR

1999 • 155 citations

A Novel Regulatory Mechanism of Map Kinases Activation and Nuclear Translocation Mediated by Pka and the Ptp-Sl Tyrosine Phosphatase

1999 • 149 citations

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

1999 • 145 citations

PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression

2003 • 140 citations

Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP)

1999 • 137 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases

1998 • 123 citations

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

1996 • 116 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents

2003 • 114 citations

Evidence That Inhibition of p44/42 Mitogen-activated Protein Kinase Signaling Is a Factor in Proteasome Inhibitor-mediated Apoptosis

2002 • 113 citations

Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

2001 • 113 citations

hVH‐5: A Protein Tyrosine Phosphatase Abundant in Brain that Inactivates Mitogen‐Activated Protein Kinase

1995 • 110 citations

Discordance between the Binding Affinity of Mitogen-activated Protein Kinase Subfamily Members for MAP Kinase Phosphatase-2 and Their Ability to Activate the Phosphatase Catalytically

2001 • 109 citations

Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)

1999 • 105 citations

Regulation of stress‐activated protein kinase signaling pathways by protein phosphatases

2002 • 102 citations

The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation

2003 • 102 citations

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

2002 • 98 citations

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

2000 • 96 citations

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

2003 • 91 citations

A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity

2003 • 89 citations

Usage of Tautomycetin, a Novel Inhibitor of Protein Phosphatase 1 (PP1), Reveals That PP1 Is a Positive Regulator of Raf-1 in Vivo

2002 • 88 citations

Mechanistic Basis for Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase 3 by Extracellular Signal-regulated Kinase

2000 • 87 citations

Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes

1990 • 85 citations

Feedback regulation of MAPK signalling by an RNA-binding protein

2003 • 83 citations

ERK1b, a 46-kDa ERK Isoform That Is Differentially Regulated by MEK

2000 • 78 citations

Modular Structure of a Docking Surface on MAPK Phosphatases

2002 • 74 citations

PTP-ER, a Novel Tyrosine Phosphatase, Functions Downstream of Ras1 to Downregulate MAP Kinase during Drosophila Eye Development

1999 • 73 citations

Induction of the mitogen‐activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

1998 • 71 citations

Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2

1999 • 65 citations

Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP

1992 • 61 citations

Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

2001 • 59 citations

Altered Regulation of ERK1b by MEK1 and PTP-SL and Modified Elk1 Phosphorylation by ERK1b Are Caused by Abrogation of the Regulatory C-terminal Sequence of ERKs

2001 • 47 citations

A novel human ERK phosphatase regulates H-ras and v-raf signal transduction

1997 • 44 citations

The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP

2000 • 43 citations

Identification of Structural Elements Involved in the Interaction of Simian Virus 40 Small Tumor Antigen with Protein Phosphatase 2A

1998 • 40 citations

Two Clusters of Residues at the Docking Groove of Mitogen-activated Protein Kinases Differentially Mediate Their Functional Interaction with the Tyrosine Phosphatases PTP-SL and STEP

2002 • 33 citations

Protein tyrosine phosphatase (PC12, Br7,Sl) family: Expression characterization in the adult human and mouse

2000 • 24 citations