Molecular recognitions in the MAP kinase cascades

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

Signaling—2000 and Beyond

2000 • 2,544 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Protein modules and signalling networks

1995 • 2,447 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

The ETS-domain transcription factor family

2001 • 1,033 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

2001 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

1999 • 454 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein

2000 • 321 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

2000 • 278 citations

Pheromone response, mating and cell biology

2000 • 274 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo

2002 • 264 citations

Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

2001 • 263 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

1999 • 250 citations

The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2

2000 • 245 citations

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

2000 • 234 citations

KSR: a MAPK scaffold of the Ras pathway?

2001 • 234 citations

UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans

2001 • 231 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

The Ste5p scaffold

2001 • 226 citations

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

2000 • 219 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5

1999 • 216 citations

KSR is a scaffold required for activation of the ERK/MAPK module

2002 • 215 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1998 • 191 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

2002 • 173 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

A Novel MAPK Phosphatase MKP-7 Acts Preferentially on JNK/SAPK and p38α and β MAPKs

2001 • 157 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

A Novel Regulatory Mechanism of Map Kinases Activation and Nuclear Translocation Mediated by Pka and the Ptp-Sl Tyrosine Phosphatase

1999 • 149 citations

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1999 • 142 citations

Identification of a Cytoplasmic-Retention Sequence in ERK2

1999 • 136 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

Interaction of c-Jun Amino-terminal Kinase Interacting Protein-1 with p190 rhoGEF and Its Localization in Differentiated Neurons

1999 • 124 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

MEKK1 Binds Raf-1 and the ERK2 Cascade Components

2000 • 120 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

2001 • 113 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

Discordance between the Binding Affinity of Mitogen-activated Protein Kinase Subfamily Members for MAP Kinase Phosphatase-2 and Their Ability to Activate the Phosphatase Catalytically

2001 • 109 citations

The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1994 • 106 citations

Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1

2001 • 91 citations

Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

2001 • 86 citations

Specificity Determinants in MAPK Signaling to Transcription Factors

2002 • 80 citations

Identification of the Anti-proliferative Protein Tob as a MAPK Substrate

2002 • 80 citations

ERK1b, a 46-kDa ERK Isoform That Is Differentially Regulated by MEK

2000 • 78 citations

Modular Structure of a Docking Surface on MAPK Phosphatases

2002 • 74 citations

PTP-ER, a Novel Tyrosine Phosphatase, Functions Downstream of Ras1 to Downregulate MAP Kinase during Drosophila Eye Development

1999 • 73 citations

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

1999 • 57 citations

Creation of a Stress-activated p90 Ribosomal S6 Kinase

2000 • 39 citations

C-terminal Elements Control Location, Activation Threshold, and p38 Docking of Ribosomal S6 Kinase B (RSKB)

2001 • 34 citations

Genetic Analysis of rolled, Which Encodes a Drosophila Mitogen-Activated Protein Kinase

1999 • 27 citations