A conserved docking motif in MAP kinases common to substrates, activators and regulators

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

1998 • 1,003 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation

1996 • 434 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

1999 • 250 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5

1999 • 216 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1998 • 191 citations

The MKK7 Gene Encodes a Group of c-Jun NH₂-Terminal Kinase Kinases

1999 • 169 citations

Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells

1996 • 166 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1999 • 142 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1994 • 106 citations

PTP-ER, a Novel Tyrosine Phosphatase, Functions Downstream of Ras1 to Downregulate MAP Kinase during Drosophila Eye Development

1999 • 73 citations

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

1999 • 66 citations