Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation

1993 • 521 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.

1994 • 305 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

The molecular and cellular basis of affinity maturation in the antibody response

1992 • 278 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

Mesoderm induction in Xenopus caused by activation of MAP kinase

1995 • 223 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

Induction of neurite outgrowth by MAP kinase in PC12 cells.

1995 • 146 citations

Involvement of the MAP kinase cascade in Xenopus mesoderm induction.

1995 • 136 citations

Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.

1994 • 108 citations

Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.

1994 • 102 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

A conserved helix motif complements the protein kinase core.

1993 • 71 citations

Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.

1994 • 57 citations

Mitogen-Activated Protein Kinase and Cytoskeleton in Mitogenic Signal Transduction

1992 • 39 citations

Activation of two Isoforms of Mitogen‐Activated Protein Kinase Kinase in Response to Epidermal Growth Factor and Nerve Growth Factor

1995 • 24 citations