Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 • 796 citations

Dual specificity phosphatases: a gene family for control of MAP kinase function

2000 • 791 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

2002 • 417 citations

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 ^MAPK -Dependent Phosphorylation

1999 • 414 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

2000 • 315 citations

MAP kinase phosphatases.

2002 • 311 citations

Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases

2002 • 293 citations

CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion

2002 • 284 citations

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

2003 • 257 citations

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

2001 • 253 citations

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.

1996 • 203 citations

The Mechanism of Dephosphorylation of Extracellular Signal-regulated Kinase 2 by Mitogen-activated Protein Kinase Phosphatase 3

2001 • 179 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos

2003 • 172 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

1999 • 145 citations

The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases

2001 • 135 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

2001 • 113 citations

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1

2002 • 102 citations

Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis

2001 • 98 citations

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

2000 • 96 citations

Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway

1996 • 88 citations

Mechanistic Basis for Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase 3 by Extracellular Signal-regulated Kinase

2000 • 87 citations

Induction of the mitogen‐activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

1998 • 71 citations

Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells

2000 • 67 citations

Mitogen-activated Protein Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-mediated Destruction

2001 • 46 citations

MKP-3 Has Essential Roles as a Negative Regulator of the Ras/Mitogen-Activated Protein Kinase Pathway during Drosophila Development

2003 • 42 citations

Activation of p42 Mitogen-activated Protein Kinase (MAPK), but not c-Jun NH₂-Terminal Kinase, Induces Phosphorylation and Stabilization of MAPK PhosphataseXCL100 inXenopusOocytes

2002 • 40 citations

Inducible expression of a MAP kinase phosphatase‐3‐GFP chimera specifically blunts fibroblast growth and ras‐dependent tumor formation in nude mice

2004 • 32 citations

Transition State Analysis and Requirement of Asp-262 General Acid/Base Catalyst for Full Activation of Dual-Specificity Phosphatase MKP3 by Extracellular Regulated Kinase

2001 • 18 citations