Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

The MAPK signaling cascade

1995 • 3,300 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Sparse matrix sampling: a screening method for crystallization of proteins

1991 • 2,050 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Influence of proline residues on protein conformation

1991 • 1,125 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Use of an oriented peptide library to determine the optimal substrates of protein kinases

1994 • 645 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

A fast algorithm for rendering space-filling molecule pictures

1988 • 616 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Regulatory Subunit Of Protein Kinase A: Structure of Deletion Mutant with cAMP Binding Domains

1995 • 381 citations

Primary Structure of BMK1: A New Mammalian MAP Kinase

1995 • 345 citations

Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins

1994 • 285 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

1992 • 263 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1

1996 • 236 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria

1997 • 199 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1993 • 170 citations

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

1995 • 148 citations

The Eukaryotic Protein Kinase Superfamily

1995 • 143 citations

Mutation of Position 52 in ERK2 Creates a Nonproductive Binding Mode for Adenosine 5‘-Triphosphate^,

1996 • 136 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

Three-dimensional Structure of Mammalian Casein Kinase I: Molecular Basis for Phosphate Recognition

1996 • 125 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences.

1987 • 95 citations

Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.

1994 • 85 citations

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.

1993 • 78 citations

Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity

1996 • 73 citations

Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.

1992 • 71 citations

MAP kinase binds to the NH₂‐terminal activation domain of c‐Myc

1994 • 66 citations

Protein kinases

1994 • 60 citations

Allosteric enzymes as models for chemomechanical energy transducing assemblies

1996 • 25 citations