Isotype-Specific Functions of Raf Kinases

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

1995 • 622 citations

The ins and outs of Raf kinases

1994 • 537 citations

Activation of the cell death program by inhibition of proteasome function

1997 • 494 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1998 • 471 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation

1997 • 434 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Activation of Raf-1 by 14-3-3 proteins

1994 • 370 citations

14-3-3 and its possible role in co-ordinating multiple signalling pathways

1996 • 367 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

14-3-3ζ Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove

1998 • 355 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility

1999 • 285 citations

Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous- growth signalling pathway

1997 • 270 citations

Regulation of Protein Phosphatase 2A by Direct Interaction with Casein Kinase 2α

1997 • 266 citations

Casein kinases: pleiotropic mediators of cellular regulation

1993 • 264 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

14-3-3 proteins associate with cdc25 phosphatases.

1995 • 251 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1996 • 234 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Differential Effects of cAMP in Neurons and Astrocytes

1999 • 222 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

TAP off - tumors on

1997 • 215 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

Bcr and Raf form a complex in vivo via 14-3-3 proteins.

1995 • 201 citations

14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules

1996 • 181 citations

Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes

1995 • 176 citations

The protein kinase KSR interacts with 14-3-3 protein and Raf

1997 • 175 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Asymmetric Expression of Protein Kinase CK2 Subunits in Human Kidney Tumors

1994 • 163 citations

How ras-related proteins talk to their effectors

1996 • 162 citations

CNK, a RAF-Binding Multidomain Protein Required for RAS Signaling

1998 • 162 citations

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization

1999 • 162 citations

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

1995 • 161 citations

Role of the β subunit of casein kinase‐2 on the stability and specificity of the recombinant reconstituted holoenzyme

1992 • 157 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Activation of Brain B-Raf Protein Kinase by Rap1B Small GTP-binding Protein

1996 • 151 citations

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1998 • 151 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

1998 • 138 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

1994 • 121 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Craf-1 protein kinase is essential for mouse development

1998 • 116 citations

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

2000 • 116 citations

The Casein Kinase II β Subunit Binds to Mos and Inhibits Mos Activity

1997 • 115 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf

1998 • 102 citations

Protein Phosphorylation

1996 • 101 citations

A‐Raf kinase is a new interacting partner of protein kinase CK2 β subunit

1997 • 101 citations

Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins

1995 • 100 citations

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

1997 • 100 citations

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1998 • 100 citations

The regulatory subunit of protein kinase CK2 is a specific A‐Raf activator

1997 • 93 citations

Biosynthesis of casein kinase II in lymphoid cell lines

1994 • 93 citations

Identification of an activation region in the proteasome activator REGα

1998 • 92 citations

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

1996 • 88 citations

Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

1999 • 77 citations

Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.

1996 • 77 citations

Biochemical and Molecular Aspects of Selected Cancers

1991 • 74 citations

A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf

1999 • 73 citations

L- and M2- pyruvate kinase expression in renal cell carcinomas and their metastases

1994 • 72 citations

TC21 and Ras share indistinguishable transforming and differentiating activities

1999 • 67 citations

Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

1994 • 66 citations

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.

1992 • 63 citations

A majority of casein kinase II ? subunit is tightly bound to intranuclear components but not to the ? subunit

1993 • 58 citations

Programmed cell death and the proteasome

1998 • 57 citations

Bcl‐2, Raf‐1 and mitochondrial regulation of apoptosis

1998 • 52 citations

Phosphorylation of c-Raf-1 by Protein Kinase A Interferes with Activation

1994 • 52 citations

Structure of protein kinase CK2: Dimerization of the human β‐subunit

1996 • 52 citations

Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cells

1996 • 51 citations

Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.

1995 • 50 citations

The β subunit of CKII negatively regulates Xenopus oocyte maturation

1997 • 49 citations

Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism

1997 • 48 citations

Identification of a latent MAP kinase kinase kinase in PC12 cells as B‐raf

1994 • 37 citations

Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase

1999 • 36 citations

Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells.

1995 • 35 citations

Cell Growth and Oncogenesis

2012 • 32 citations

CK2alpha-protein phosphatase 2A molecular complex: possible interaction with the MAP kinase pathway.

1999 • 30 citations

Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.

1998 • 27 citations

Different Effects of Various Phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf Activation

1996 • 22 citations

Pyruvate Kinase in Selected Human Tumors

1991 • 20 citations

Cell Growth and Oncogenesis

1998 • 14 citations

Apoptosis Regulation by Raf, Bcl-2, and R-Ras

1997 • 10 citations

Difference in the Mechanism of Interaction of Raf-1 and B-Raf with H-Ras

1996 • 8 citations

Raf-dependent signaling pathways in cell growth and differentiation

1998 • 5 citations

Deleted Work

1955 • 0 citations