Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

2000 • 503 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

1998 • 311 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Identification of a Cytoplasmic-Retention Sequence in ERK2

1999 • 136 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo

1999 • 107 citations

MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

1999 • 93 citations

Deuterium Exchange Mass Spectrometry as a Probe of Protein Kinase Activation. Analysis of Wild-Type and Constitutively Active Mutants of MAP Kinase Kinase-1

1998 • 70 citations

The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells

1998 • 69 citations

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

1999 • 66 citations

Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

2001 • 59 citations

Creation of a Stress-activated p90 Ribosomal S6 Kinase

2000 • 39 citations