EGFR and FGFR Signaling through FRS2 Is Subject to Negative Feedback Control by ERK1/2

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

2002 • 973 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Signal transduction by fibroblast growth factor receptors

1999 • 419 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

2000 • 355 citations

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

1998 • 322 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

1999 • 291 citations

Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

2001 • 287 citations

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

1999 • 231 citations

Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

2000 • 230 citations

Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by Protein Kinase B Positively Regulates IRS-1 Function

1999 • 195 citations

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

1993 • 170 citations

Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins

1998 • 167 citations

Insulin Stimulates PKCζ-mediated Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

2001 • 157 citations

The Docking Protein FRS2α Controls a MAP Kinase-Mediated Negative Feedback Mechanism for Signaling by FGF Receptors

2002 • 155 citations

ERK Negatively Regulates the Epidermal Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase

2002 • 144 citations

Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade

2001 • 136 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Neurite growth promotion by nerve growth factor and insulin‐like growth factor‐1 in cultured adult sensory neurons: Role of phosphoinositide 3‐kinase and mitogen activated protein kinase

2001 • 112 citations

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

2001 • 107 citations

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1999 • 104 citations

Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.

1996 • 102 citations

Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.

1993 • 95 citations

Positive and Negative Regulatory Role of Insulin Receptor Substrate 1 and 2 (IRS-1 and IRS-2) Serine/Threonine Phosphorylation

2002 • 93 citations

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2

2002 • 87 citations

ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase

2001 • 65 citations

SHP2 Associates Directly with Tyrosine Phosphorylated p90 (SNT) Protein in FGF-Stimulated Cells

1997 • 51 citations

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

2001 • 47 citations

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation

1995 • 47 citations

Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.

1996 • 43 citations

Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1

1999 • 37 citations

Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2

1999 • 33 citations

Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor‐induced signaling

2002 • 23 citations

Potential Involvement of FRS2 in Insulin Signaling1

2000 • 18 citations

Potential Involvement of FRS2 in Insulin Signaling

2000 • 2 citations