Molecular Mechanisms of Treg-Mediated T Cell Suppression

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Regulation and Function of NF-κB Transcription Factors in the Immune System

2009 • 2,403 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 • 2,075 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

T Cell Activation

2009 • 1,898 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Regulatory T Cells

2000 • 1,827 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

2011 • 1,570 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

2007 • 1,418 citations

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

2009 • 1,338 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

2006 • 1,227 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Calcium signalling in lymphocyte activation and disease

2007 • 990 citations

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

2006 • 982 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

2009 • 934 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

2009 • 898 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

2011 • 834 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

2009 • 798 citations

IL-35-mediated induction of a potent regulatory T cell population

2010 • 791 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

2010 • 760 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

Regulatory T cells and infection: a dangerous necessity

2007 • 728 citations

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 • 715 citations

CD28-mediated co-stimulation: a quantitative support for TCR signalling

2003 • 713 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

2007 • 686 citations

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

2001 • 680 citations

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

2010 • 675 citations

Stability of the Regulatory T Cell Lineage in Vivo

2010 • 675 citations

Foxp3⁺natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation

2008 • 663 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 • 657 citations

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

2006 • 652 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

2007 • 618 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Infectious Tolerance

2002 • 614 citations

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

2000 • 591 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Reversal of the TCR Stop Signal by CTLA-4

2006 • 584 citations

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

2008 • 582 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

2008 • 573 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

2011 • 568 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Interleukin‐2 is essential for CD4⁺CD25⁺ regulatory T cell function

2004 • 521 citations

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

2008 • 509 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

2006 • 502 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

2009 • 495 citations

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

2008 • 494 citations

Regulatory Lymphocytes and Intestinal Inflammation

2009 • 489 citations

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

2011 • 488 citations

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

2010 • 486 citations

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

2007 • 477 citations

Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation

2006 • 475 citations

IL-17–producing human peripheral regulatory T cells retain suppressive function

2009 • 471 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5′-Adenosine Monophosphate to Adenosine

2006 • 440 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo

2006 • 422 citations

MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells

2006 • 416 citations

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

2011 • 407 citations

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

2006 • 407 citations

Developmental plasticity of Th17 and Treg cells

2009 • 405 citations

Calcium signaling in lymphocytes

2008 • 394 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

2008 • 377 citations

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

2004 • 377 citations

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells

2006 • 377 citations

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+ Regulatory T Cells

2009 • 363 citations

The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor

1998 • 363 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Transient regulatory T-cells: A state attained by all activated human T-cells

2006 • 336 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

2008 • 333 citations

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Ca _V 1.2 Channels

2010 • 329 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner

2008 • 323 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

2010 • 317 citations

Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4⁺ CD25⁺ regulatory T‐cell‐mediated suppression

2006 • 315 citations

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose

1999 • 308 citations

Activation requirements for the induction of CD4⁺CD25⁺ T cell suppressor function

2004 • 307 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

2004 • 297 citations

The ‘short’ history of regulatory B cells

2007 • 277 citations

Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression

2009 • 274 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

2011 • 270 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

DC activated via dectin‐1 convert Treg into IL‐17 producers

2008 • 262 citations

Regulatory T cells and treatment of cancer

2008 • 253 citations

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2009 • 250 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

CD4+ regulatory T cells

2001 • 241 citations

Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous

1999 • 236 citations

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

2005 • 225 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

2006 • 200 citations

Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance

2011 • 199 citations

CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production

2005 • 198 citations

NFAT pulls the strings during CD4+ T helper cell effector functions

2010 • 198 citations

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

2008 • 194 citations

T cell receptor signalling

2001 • 188 citations

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

2010 • 187 citations

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

2009 • 184 citations

IL-27 inhibits the development of regulatory T cells via STAT3

2007 • 180 citations

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

2011 • 180 citations

Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10

2003 • 176 citations

Protein Kinase C and Calcineurin Synergize to Activate IκB Kinase and NF-κB in T Lymphocytes

1999 • 168 citations

Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

2008 • 165 citations

A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell–mediated suppression

2008 • 164 citations

Regulation of Interferon-γ Gene Expression

1996 • 160 citations

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

2011 • 154 citations

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4+CD25+ regulatory T cells

2007 • 150 citations

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

2009 • 150 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

Extracellular redox modulation by regulatory T cells

2009 • 139 citations

CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation

2005 • 139 citations

CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy

2001 • 137 citations

IL-15 Renders Conventional Lymphocytes Resistant to Suppressive Functions of Regulatory T Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway

2009 • 134 citations

Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells

2006 • 128 citations

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

2011 • 127 citations

Suppressive properties of human CD4⁺CD25⁺ regulatory T cells are dependent on CTLA‐4 expression

2004 • 126 citations

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-κB induction

2002 • 123 citations

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals

2007 • 121 citations

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

2004 • 120 citations

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

2008 • 114 citations

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

2009 • 112 citations

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

2010 • 111 citations

Rapid Suppression of Cytokine Transcription in Human CD4+CD25− T Cells by CD4+Foxp3+ Regulatory T Cells: Independence of IL-2 Consumption, TGF-β, and Various Inhibitors of TCR Signaling

2007 • 109 citations

Calcium-dependent activation of T-lymphocytes

2004 • 107 citations

Second Messenger Function of Nicotinic Acid Adenine Dinucleotide Phosphate Revealed by an Improved Enzymatic Cycling Assay

2006 • 101 citations

Transplantation Survival Is Maintained by Granzyme B+ Regulatory Cells and Adaptive Regulatory T Cells

2008 • 99 citations

The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

2011 • 98 citations

Ca²⁺/Calmodulin-Dependent Protein Kinase II Is a Modulator of CARMA1-Mediated NF-κB Activation

2006 • 96 citations

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation

2011 • 92 citations

Acquisition of Suppressive Function by Activated Human CD4+CD25− T Cells Is Associated with the Expression of CTLA-4 Not FoxP3

2008 • 83 citations

Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10

2011 • 83 citations

NFATc1 autoregulation: a crucial step for cell-fate determination

2006 • 82 citations

Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

2009 • 81 citations

CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1

2004 • 78 citations

Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression

2007 • 77 citations

Immune Regulation by Self-Reactive T Cells is Antigen Specific

2004 • 76 citations

Regulatory T cells in experimental autoimmune disease

2006 • 74 citations

Selective function of PKC-theta in T cells.

2006 • 70 citations

Cutting Edge: Regulatory T Cells Do Not Require Stimulation through Their TCR to Suppress

2009 • 69 citations

Early Kinetic Window of Target T Cell Susceptibility to CD25+ Regulatory T Cell Activity

2005 • 68 citations

ICER/CREM‐mediated transcriptional attenuation of IL‐2 and its role in suppression by regulatory T cells

2007 • 66 citations

Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis

2005 • 66 citations

Calcium channels in lymphocytes

2001 • 63 citations

Suppression of T cell function: a potential role for transcriptional repressor ICER

2000 • 63 citations

Human Regulatory T Cells Rapidly Suppress T Cell Receptor–Induced Ca ²⁺ , NF-κB, and NFAT Signaling in Conventional T Cells

2011 • 60 citations

Knock-down of the Type 3 Ryanodine Receptor Impairs Sustained Ca2+ Signaling via the T Cell Receptor/CD3 Complex

2002 • 59 citations

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

2011 • 59 citations

Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation

2009 • 53 citations

Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells

2005 • 52 citations

Dephosphorylation of Bcl‐10 by calcineurin is essential for canonical NF‐κB activation in Th cells

2011 • 52 citations

Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing

2008 • 51 citations

T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity

2009 • 49 citations

‘Vive la Résistance!’ – the PI3K–Akt pathway can determine target sensitivity to regulatory T cell suppression

2007 • 46 citations

Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation

2010 • 45 citations

Transcriptional regulation of T cell tolerance

2007 • 41 citations

Imaging the function of regulatory T cells in vivo

2006 • 41 citations

Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells

2009 • 36 citations

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

2009 • 35 citations

Regulatory T cell-mediated suppression: potential role of ICER

2006 • 33 citations

IP3 Receptor-Mediated Ca2+ Release in Naive CD4 T Cells Dictates Their Cytokine Program

2008 • 32 citations

Distinct Molecular Program Imposed on CD4+ T Cell Targets by CD4+CD25+ Regulatory T Cells

2006 • 32 citations

Regulatory T Cells Inhibit Protein Kinase Cθ Recruitment to the Immune Synapse of Naive T Cells with the Same Antigen Specificity

2006 • 32 citations

Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-β-dependent mechanism

2008 • 32 citations

Keeping the (Kinase) Party Going: SLP-76 and ITK Dance to the Beat

2007 • 30 citations

Identification of IL-17-producing FOXP3+ regulatory T cells in humans (89.1)

2009 • 29 citations

CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB

2011 • 29 citations

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

2006 • 27 citations

Oxidized Low-density Lipoprotein-induced Proinflammatory Cytokine Response in Macrophages are Suppressed by CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;+&lt;/sup&gt;Foxp3&lt;sup&gt;+&lt;/sup&gt; Regulatory T Cells Through Downregulating Toll Like Receptor 2-mediated Activation of NF-ĸB

2010 • 26 citations

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

2011 • 26 citations

Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways

2011 • 24 citations

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2009 • 22 citations

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

2011 • 19 citations

CD4+CD25+ Regulatory T Cells Attenuate the Phosphatidylinositol 3-Kinase/Akt Pathway in Antigen-Primed Immature CD8+ CTLs during Functional Maturation

2005 • 16 citations

Tregs utilize β-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation

2009 • 16 citations

Interaction of calmodulin with Bcl10 modulates NF-κB activation

2010 • 15 citations

Antibody blocking of MHC II on human activated regulatory T cells abrogates their suppressive potential

2007 • 14 citations

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

2011 • 9 citations

Cord Blood CD4+CD25+ Derived T Regulatory Cell Lines Express FoxP3 Protein and Manifest Potent Suppressor Function.

2004 • 8 citations

Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

2009 • 8 citations

Vive la resistance

2006 • 7 citations

Deleted Work

1955 • 0 citations