Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Cyclic AMP

1968 • 954 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

1993 • 592 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent

2005 • 507 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1957 • 486 citations

Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease

2001 • 384 citations

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

1999 • 259 citations

The Permeability of Gap Junction Channels to Probes of Different Size Is Dependent on Connexin Composition and Permeant-Pore Affinities

2004 • 258 citations

Connexins and their channels in cell growth and cell death

2005 • 232 citations

Regulation of interleukin 2 synthesis by cAMP in human T cells.

1987 • 197 citations

Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication

2001 • 196 citations

Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo

2005 • 147 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling

2004 • 141 citations

Selective Permeability of Different Connexin Channels to the Second Messenger Cyclic AMP

2005 • 98 citations

cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

1988 • 97 citations

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

1996 • 91 citations

Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)

2001 • 66 citations

Flow cytometry analysis of gap junction‐mediated cell–cell communication: Advantages and pitfalls

2006 • 41 citations

Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: suppression of disease by a phosphodiesterase inhibitor

2005 • 41 citations

PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes

2006 • 40 citations

Potential Use of an Antagonist of Camp-Dependent Protein Kinase to Block Inhibition and Modulate T-Cell Receptor-Triggered Activation of Cytotoxic T-Lymphocytes

1989 • 22 citations