Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

T cell killing does not require the formation of a stable mature immunological synapse

2004 • 569 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

The Role of Calcium in the Regulation of Apoptosis

1997 • 460 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

The Ca2+ pump of the plasma membrane.

1992 • 382 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

Protein kinase Cθ: a new essential superstar on the T-cell stage

2000 • 144 citations

The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

1995 • 143 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

NF-κB activation induced by TCR/CD28 costimulation is mediated by PKC-θ

2000 • 124 citations

Calcium signalling in lymphocytes

2003 • 119 citations

Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec

2004 • 93 citations

SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway

2004 • 89 citations

PKCθ Signals Activation versus Tolerance In Vivo

2004 • 84 citations

PLC gamma 1, a possible mediator of T cell receptor function.

1991 • 73 citations

Positive feedback regulation of PLCγ1/Ca²⁺ signaling by PKCθ in restimulated T cells via a Tec kinase‐dependent pathway

2004 • 66 citations

Ca2+ Signaling in T-Lymphocytes

1998 • 65 citations

A Role for Protein Kinase CβI in the Regulation of Ca2+ Entry in Jurkat T Cells

1997 • 35 citations

Inhibition of T-Cell Antigen Receptor-Mediated Transmembrane Signaling by Protein Kinase C Activation

1988 • 32 citations

Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation.

1988 • 21 citations