Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

2003 • 1,267 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

2005 • 439 citations

Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD

2004 • 420 citations

Quantification of regulatory T cells in patients with systemic lupus erythematosus

2003 • 417 citations

Human CD4+CD25+ regulatory T cells

2004 • 389 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Effective treatment of collagen‐induced arthritis by adoptive transfer of CD25+ regulatory T cells

2005 • 378 citations

L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

2004 • 360 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4

2003 • 301 citations

A peripheral circulating compartment of natural naive CD4+ Tregs

2005 • 299 citations

Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

2004 • 297 citations

In vivo peripheral expansion of naive CD4+CD25highFoxP3+ regulatory T cells in patients with multiple myeloma

2006 • 290 citations

Persistence of naive CD45RA+ regulatory T cells in adult life

2005 • 267 citations

Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network

2005 • 235 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4+25+ T cells to allow an effective graft-versus-leukemia response

2003 • 199 citations

Regulatory T-cell therapy: is it ready for the clinic?

2005 • 195 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

2005 • 180 citations

Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation

2004 • 174 citations

Regulatory T cells in spontaneous autoimmune encephalomyelitis

2001 • 162 citations

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

2006 • 161 citations

Antigen-specific regulatory T cells—Ex vivo expansion and therapeutic potential

2006 • 136 citations

Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells

2006 • 135 citations

L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated T Lymphocytes

2003 • 133 citations

Isolation of CD4+CD25+ Regulatory T Cells for Clinical Trials

2006 • 133 citations

Clinical application of expanded CD4+25+ cells

2006 • 94 citations

Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation.

1988 • 80 citations

Early Kinetic Window of Target T Cell Susceptibility to CD25+ Regulatory T Cell Activity

2005 • 68 citations

CD4+CD25+ Regulatory T Cells and Graft-Versus-Host Disease

2006 • 58 citations