T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

2004 • 2,381 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Semisynthesis of Proteins by Expressed Protein Ligation

2003 • 684 citations

Inhibition of p38 MAP kinase as a therapeutic strategy

2000 • 463 citations

Regulation of the MEF2 Family of Transcription Factors by p38

1999 • 429 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases

2005 • 292 citations

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.

1999 • 290 citations

Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase α, β, γ, and δ in Inflammatory Cell Lineages

1999 • 238 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH₂-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5

1999 • 212 citations

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

2002 • 202 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors

2000 • 196 citations

Bcl-2 Phosphorylation by p38 MAPK

2006 • 192 citations

The JNK and P38 MAP kinase signaling pathways in T cell–mediated immune responses44This team of investigators has contributed extensively to the field of MAP kinase signal transduction in thymocyte and T cell differentiation.

2000 • 161 citations

The structure of phosphorylated P38γ is monomeric and reveals a conserved activation-loop conformation

1999 • 129 citations

Gadd45β is important for perpetuating cognate and inflammatory signals in T cells

2003 • 129 citations

Unwinding the loop of Bcl-2 phosphorylation

2001 • 129 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors

2006 • 112 citations

Stability of the ATF2 Transcription Factor Is Regulated by Phosphorylation and Dephosphorylation

2000 • 107 citations

The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway

2005 • 98 citations

Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8⁺ but Not CD4⁺ T Cells

2000 • 98 citations

Stress-activated protein kinases—tumor suppressors or tumor initiators?

2004 • 92 citations

The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors.

1997 • 91 citations

Isolation of Hyperactive Mutants of the MAPK p38/Hog1 That Are Independent of MAPK Kinase Activation

2001 • 78 citations

p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8⁺ T Cells

2006 • 77 citations

The Kinetic Mechanism of the Dual Phosphorylation of the ATF2 Transcription Factor by p38 Mitogen-activated Protein (MAP) Kinase α

2001 • 76 citations

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

2008 • 72 citations

Active Mutants of the Human p38α Mitogen-activated Protein Kinase

2004 • 71 citations

Structures of p38α Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation

2006 • 67 citations

The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop

2002 • 62 citations

Selective Requirement of p38α MAPK in Cytokine-Dependent, but Not Antigen Receptor-Dependent, Th1 Responses

2006 • 55 citations

Catalysis and Function of the p38α·MK2a Signaling Complex

2004 • 50 citations

Hydrogen-Exchange Mass Spectrometry Reveals Activation-Induced Changes in the Conformational Mobility of p38α MAP Kinase

2008 • 39 citations

p38α Is Active in Vitro and in Vivo When Monophosphorylated at Threonine 180

2009 • 38 citations

Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor–mediated p38α activation and impairs interferon-γ production

2008 • 36 citations

A mechanism underlying STAT4-mediated up-regulation of IFN- induction inTCR-triggered T cells

2004 • 27 citations

Stress-Activated Protein Kinases

2008 • 17 citations