Dephosphorylation of Bcl‐10 by calcineurin is essential for canonical NF‐κB activation in Th cells

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Signaling to NF-κB

2004 • 3,768 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Essential function for the kinase TAK1 in innate and adaptive immune responses

2005 • 927 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

IκB kinase complexes: gateways to NF-κB activation and transcription

2006 • 628 citations

Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

2000 • 453 citations

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

2000 • 445 citations

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

1999 • 383 citations

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

2004 • 378 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

Roles of the NF- B Pathway in Lymphocyte Development and Function

2009 • 285 citations

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

2008 • 284 citations

Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import

2004 • 224 citations

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

2010 • 211 citations

Protein kinase C theta (PKCθ): A key player in T cell life and death

2007 • 183 citations

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

2003 • 183 citations

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

1997 • 154 citations

Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

2004 • 135 citations

Essential Role for IκB Kinase β in Remodeling Carma1-Bcl10-Malt1 Complexes upon T Cell Activation

2006 • 131 citations

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-κB induction

2002 • 123 citations

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

2004 • 113 citations

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

2009 • 102 citations

Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways

2007 • 102 citations

Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors

2006 • 101 citations

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

2004 • 92 citations

Dynamic regulation of T‐cell costimulation through TCR–CD28 microclusters

2009 • 90 citations

Negative feedback loop in T cell activation through IκB kinase-induced phosphorylation and degradation of Bcl10

2007 • 89 citations

Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol

2001 • 85 citations

Cyclosporin A interferes with the inducible degradation of NF-xB inhibitors, but not with the processing of p105/NF-xB1 in T cells

1997 • 79 citations

Post-translational modifications regulate distinct functions of CARMA1 and BCL10

2007 • 51 citations

Morpholino Antisense Oligonucleotide-Mediated Gene Knockdown During Thymocyte Development Reveals Role for Runx3 Transcription Factor in CD4 Silencing During Development of CD4−/CD8+ Thymocytes

2003 • 50 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II

2006 • 38 citations

Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation

2007 • 37 citations

Substitution in Position 3 of Cyclosporin A Abolishes the Cyclophilin-mediated Gain-of-function Mechanism but Not Immunosuppression

2004 • 36 citations

Inhibition of calcineurin‐NFAT signaling by the pyrazolopyrimidine compound NCI3

2007 • 24 citations

UV-light induces p38 MAPK-dependent phosphorylation of Bcl10

2003 • 15 citations