Calcium signaling in lymphocytes

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

2005 • 2,020 citations

Transcriptional regulation by calcium, calcineurin, and NFAT

2003 • 1,893 citations

STIM1, an essential and conserved component of store-operated Ca2+ channel function

2005 • 1,757 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

Orai1 is an essential pore subunit of the CRAC channel

2006 • 1,305 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Calcium signalling in lymphocyte activation and disease

2007 • 990 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

2006 • 838 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

2006 • 772 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

2007 • 649 citations

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 • 630 citations

STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels

2006 • 627 citations

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca ²⁺ store depletion

2007 • 592 citations

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

2006 • 576 citations

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

2008 • 573 citations

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

2006 • 571 citations

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 • 555 citations

Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 • 547 citations

The molecular choreography of a store-operated calcium channel

2007 • 502 citations

Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

2000 • 453 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY

2005 • 434 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance

2005 • 406 citations

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

2003 • 400 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels

2007 • 388 citations

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

2008 • 387 citations

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

2006 • 383 citations

Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

2006 • 382 citations

Biochemical and Functional Characterization of Orai Proteins

2007 • 375 citations

Integration of calcium and RAS signalling

2002 • 375 citations

CRACM1, CRACM2, and CRACM3 Are Store-Operated Ca2+ Channels with Distinct Functional Properties

2007 • 369 citations

Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses

2007 • 331 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Antigen-Receptor Signaling to Nuclear Factor κB

2006 • 320 citations

Coupling of STIM1 to store-operated Ca ²⁺ entry through its constitutive and inducible movement in the endoplasmic reticulum

2006 • 300 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 294 citations

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

1998 • 271 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

2008 • 255 citations

Delivering the kiss of death: progress on understanding how perforin works

2007 • 250 citations

Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 Complex

2007 • 247 citations

STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry

2006 • 241 citations

Mapping the Interacting Domains of STIM1 and Orai1 in Ca2+ Release-activated Ca2+ Channel Activation

2007 • 237 citations

Calcium Inhibition and Calcium Potentiation of Orai1, Orai2, and Orai3 Calcium Release-activated Calcium Channels

2007 • 236 citations

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment

2005 • 235 citations

Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation

2006 • 230 citations

Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

2006 • 225 citations

Calcium signalling and cell-fate choice in B cells

2007 • 219 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

2007 • 206 citations

Identification of stromal cell products that interact with pre-B cells.

1996 • 188 citations

A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1

2004 • 178 citations

Integration of Notch 1 and Calcineurin/NFAT Signaling Pathways in Keratinocyte Growth and Differentiation Control

2005 • 176 citations

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1995 • 174 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

2002 • 153 citations

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

2008 • 147 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings

1996 • 127 citations

Dissecting ICRAC, a store-operated calcium current

2007 • 113 citations

Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice.

1988 • 111 citations

The Calcineurin Phosphatase Complex Modulates Immunogenic B Cell Responses

2006 • 101 citations

Ca2+ Signals in CD4+ T Cells during Early Contacts with Antigen-Bearing Dendritic Cells in Lymph Node

2007 • 88 citations

Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

2007 • 65 citations

Selective Role of NFATc3 in Positive Selection of Thymocytes

2007 • 46 citations

Distinct NFAT Family Proteins Are Involved in the Nuclear NFAT-DNA Binding Complexes from Human Thymocyte Subsets

1998 • 42 citations

A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation

2007 • 38 citations