Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

2005 • 844 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

2003 • 458 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

Stat5a/b are essential for normal lymphoid development and differentiation

2006 • 369 citations

Stat5 Activation Plays a Critical Role in Th2 Differentiation

2003 • 357 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media.

1980 • 291 citations

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

2001 • 270 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

IL-7: maintaining T-cell memory and achieving homeostasis

2005 • 232 citations

TH1 and TH2 cells: a historical perspective

2002 • 230 citations

IL-27 Limits IL-2 Production during Th1 Differentiation

2006 • 213 citations

IL-2 Secretion by CD4+ T Cells In Vivo Is Rapid, Transient, and Influenced by TCR-Specific Competition

2004 • 166 citations

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

1984 • 141 citations

Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement.

1993 • 139 citations

IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508

2005 • 138 citations

Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation

2004 • 137 citations

In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells

2001 • 113 citations

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common γ-Chain

1998 • 83 citations

Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy

2001 • 55 citations