Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance

How regulatory T cells work

2008 • 3,048 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Infectious immunological tolerance.

1971 • 811 citations

IL-35-mediated induction of a potent regulatory T cell population

2010 • 791 citations

Infectious Tolerance

2002 • 614 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Regulatory T Cell Suppression Is Potentiated by Target T Cells in a Cell Contact, IL-35- and IL-10-Dependent Manner

2009 • 248 citations

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

2007 • 218 citations

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

2008 • 194 citations

In Vitro Treg Suppression Assays

2011 • 189 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Infectious tolerance and the long‐term acceptance of transplanted tissue

2006 • 168 citations

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

2008 • 114 citations

T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects

2008 • 107 citations

Human rhinoviruses induce IL‐35‐producing Treg via induction of B7‐H1 (CD274) and sialoadhesin (CD169) on DC

2009 • 81 citations

Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic Hepatitis B patients

2011 • 53 citations