T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Mast cells are essential intermediaries in regulatory T-cell tolerance

2006 • 742 citations

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 • 715 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 • 657 citations

Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

2007 • 481 citations

Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

2007 • 475 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

2008 • 418 citations

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

2008 • 400 citations

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

2006 • 390 citations

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

2008 • 377 citations

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

2003 • 312 citations

SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment

2008 • 311 citations

Requirement of Endogenous Stem Cell Factor and Granulocyte-Colony-Stimulating Factor for IL-17-Mediated Granulopoiesis

2000 • 266 citations

Mast Cell-Associated TNF Promotes Dendritic Cell Migration

2006 • 262 citations

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

2008 • 261 citations

Mast cells are an essential hematopoietic component for polyp development

2007 • 242 citations

Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

2008 • 232 citations

Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma

2000 • 218 citations

High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas

2007 • 210 citations

CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.

2003 • 206 citations

CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice

2005 • 203 citations

Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma

2002 • 201 citations

Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

2008 • 193 citations

Mast cell–derived TNF can promote Th17 cell–dependent neutrophil recruitment in ovalbumin-challenged OTII mice

2006 • 157 citations

Interleukin-10 Inhibits Tumor Metastasis, Downregulates MHC Class I, and Enhances NK Lysis

1997 • 138 citations

Mast cell infiltration around gastric cancer cells correlates with tumor angiogenesis and metastasis

1999 • 125 citations

Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

2007 • 124 citations

Mast Cells Have a Pivotal Role in TNF-Independent Lymph Node Hypertrophy and the Mobilization of Langerhans Cells in Response to Bacterial Peptidoglycan

2006 • 119 citations

The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer

2006 • 118 citations

Association of Mast Cells with Microvessel Density in Renal Cell Carcinomas

2006 • 89 citations

Mast Cells Have Prognostic Value in Merkel Cell Carcinoma

2008 • 88 citations

Mast cells and eosinophils in invasive breast carcinoma

2007 • 78 citations

Mast cells in colorectal neoplasias and premalignant disorders

1995 • 66 citations

IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells

2007 • 55 citations

Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation

2008 • 52 citations

Secretory granules of mast cells accumulate mature and immature MHC class II molecules

2001 • 43 citations