Regulatory Lymphocytes and Intestinal Inflammation

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

2004 • 4,044 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

A microbial symbiosis factor prevents intestinal inflammatory disease

2008 • 2,187 citations

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 • 2,075 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2008 • 1,801 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

2008 • 1,624 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

2000 • 1,406 citations

Anatomical basis of tolerance and immunity to intestinal antigens

2003 • 1,365 citations

Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

2006 • 1,344 citations

IL-22 Increases the Innate Immunity of Tissues

2004 • 1,330 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

2008 • 1,062 citations

Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

2003 • 1,023 citations

The Biology of Interleukin-2

2007 • 986 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

2008 • 969 citations

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

2007 • 968 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation

2002 • 929 citations

The genetics and immunopathogenesis of inflammatory bowel disease

2008 • 920 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Dendritic cells in intestinal immune regulation

2008 • 745 citations

A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease

2004 • 724 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

2007 • 686 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

2007 • 676 citations

Newly identified genetic risk variants for celiac disease related to the immune response

2008 • 669 citations

Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

2006 • 664 citations

The regulation of IgA class switching

2008 • 654 citations

Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells

2002 • 639 citations

Peripheral and Intestinal Regulatory CD4+CD25high T Cells in Inflammatory Bowel Disease

2005 • 604 citations

Trefoil factors: initiators of mucosal healing

2003 • 601 citations

TH1 cells control themselves by producing interleukin-10

2007 • 599 citations

Reversal of the TCR Stop Signal by CTLA-4

2006 • 584 citations

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

2008 • 582 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

Oral tolerance

2005 • 573 citations

M<scp>olecular</scp>D<scp>efects in</scp>H<scp>uman</scp>S<scp>evere</scp>C<scp>ombined</scp>I<scp>mmunodeficiency and</scp>A<scp>pproaches to</scp>I<scp>mmune</scp>R<scp>econstitution</scp>

2004 • 524 citations

Interleukin‐2 is essential for CD4⁺CD25⁺ regulatory T cell function

2004 • 521 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Control of intestinal inflammation by regulatory T cells

2001 • 496 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

2007 • 477 citations

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

2005 • 474 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

Interleukin-22, a Member of the IL-10 Subfamily, Induces Inflammatory Responses in Colonic Subepithelial Myofibroblasts

2005 • 474 citations

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

2002 • 461 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo

2006 • 422 citations

TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive Milieu

2001 • 414 citations

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes

2006 • 408 citations

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

1996 • 399 citations

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

2008 • 393 citations

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

2006 • 390 citations

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

2007 • 388 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

Celiac disease: pathogenesis of a model immunogenetic disease

2007 • 387 citations

The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor

1998 • 363 citations

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

2006 • 361 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4⁺ CD25⁺ regulatory T‐cell‐mediated suppression

2006 • 315 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

Intraepithelial T Cells of the TcRγ/δ⁺CD8⁻ and Vδ1/Jδ1⁺ Phenotypes are Increased in Coeliac Disease

1989 • 311 citations

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

2006 • 305 citations

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

2007 • 302 citations

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

2007 • 298 citations

Not always the bad guys: B cells as regulators of autoimmune pathology

2008 • 293 citations

Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease

2007 • 285 citations

Altered Immune Responses in Interleukin 10 Transgenic Mice

1997 • 279 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin β Receptor, and TNF Receptor I Function

2003 • 271 citations

The response of the lymphatic tissue to the microbial flora. Studies on germfree mice.

1963 • 251 citations

Transforming growth factor induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

2005 • 237 citations

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

1996 • 236 citations

Cutting Edge: Critical Role for A2A Adenosine Receptors in the T Cell-Mediated Regulation of Colitis

2006 • 233 citations

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

2008 • 232 citations

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut Integrity

2002 • 227 citations

Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice

2003 • 226 citations

Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins

2007 • 217 citations

Chronic active hepatitis in mice caused by Helicobacter hepaticus.

1994 • 211 citations

Bacterial-Reactive T Regulatory Cells Inhibit Pathogenic Immune Responses to the Enteric Flora

2002 • 203 citations

The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells

2007 • 197 citations

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

2008 • 196 citations

Revival of CD8+ Treg–mediated suppression

2008 • 192 citations

IL‐27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

2007 • 188 citations

Loss of transforming growth factor β signalling in the intestine contributes to tissue injury in inflammatory bowel disease

2001 • 187 citations

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

2007 • 186 citations

Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease

2008 • 182 citations

Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients with Inflammatory Bowel Disease

2005 • 182 citations

WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells

2007 • 181 citations

Ligation of intestinal epithelial CD1d induces bioactive IL-10: Critical role of the cytoplasmic tail in autocrine signaling

1999 • 179 citations

Transforming Growth Factor-β Mediates Intestinal Healing and Susceptibility to Injury in Vitro and in Vivo Through Epithelial Cells

2003 • 178 citations

MR1-Restricted Vα19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response

2006 • 167 citations

IL-23 and Th17 cytokines in intestinal homeostasis

2008 • 157 citations

Mucosal T Cells Bearing TCRγδ Play a Protective Role in Intestinal Inflammation

2004 • 152 citations

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

2007 • 150 citations

Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

2004 • 149 citations

Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells

2003 • 142 citations

Gliadin-Specific Type 1 Regulatory T Cells from the Intestinal Mucosa of Treated Celiac Patients Inhibit Pathogenic T Cells

2006 • 135 citations

Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine

2007 • 131 citations

CD1d- and MR1-restricted invariant T cells: of mice and men

2006 • 129 citations

CCR4-dependent regulatory T cell function in inflammatory bowel disease

2007 • 128 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis

2005 • 124 citations

Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications

2006 • 122 citations

CD8+CD28− Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice

2006 • 109 citations

Intestinal Lamina Propria Retaining CD4+CD25+ Regulatory T Cells Is A Suppressive Site of Intestinal Inflammation

2007 • 101 citations

γδ T cells: firefighters or fire boosters in the front lines of inflammatory responses

2007 • 97 citations

Role of TCR specificity in CD4⁺CD25⁺ regulatory T‐cell selection

2006 • 95 citations

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes

2008 • 94 citations

Regulation of Immunity by a Novel Population of Qa-1-Restricted CD8αα+TCRαβ+ T Cells

2006 • 92 citations

Th3 Cells in Peripheral Tolerance. II. TGF-β-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity

2007 • 78 citations

The immunoregulatory effects of Qa‐1

2006 • 72 citations

Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium -Induced Colitis

2008 • 67 citations

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

1999 • 66 citations

Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease

2007 • 62 citations

β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse

1999 • 54 citations

The Role of the CTLA4 Blockade in the Treatment of Malignant Melanoma

2007 • 48 citations

Role of NKT Cells in the Digestive System. III. Role of NKT cells in intestinal immunity

2007 • 41 citations

Virus-Induced Activation of Self-Specific TCRαβ CD8αα Intraepithelial Lymphocytes Does Not Abolish Their Self-Tolerance in the Intestine

2004 • 41 citations

Serodiagnosis of Helicobacter hepaticus infection in mice by an enzyme-linked immunosorbent assay

1997 • 34 citations

Long-term treatment with anti-α4 integrin antibodies aggravates colitis in Gαi2-deficient mice

2005 • 32 citations

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

2004 • 32 citations

rHuKGF ameliorates symptoms in DSS and CD4⁺CD45RB^HiT cell transfer mouse models of inflammatory bowel disease

2002 • 29 citations

DX5⁺NKT cells induce the death of colitis‐associated cells: involvement of programmed death ligand‐1

2006 • 29 citations

An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells☆

2004 • 28 citations

Mucosal immunity

2005 • 15 citations

Gastrointestinal Manifestations of AIDS

2004 • 6 citations