‘Vive la Résistance!’ – the PI3K–Akt pathway can determine target sensitivity to regulatory T cell suppression

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Distinct molecular mechanism for initiating TRAF6 signalling

2002 • 642 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

The role of PI3K in immune cells

2003 • 460 citations

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

2004 • 384 citations

PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

2004 • 369 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

2003 • 243 citations

Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells

2005 • 213 citations

TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

2006 • 200 citations

Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

2003 • 199 citations

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

2006 • 190 citations

Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation

2005 • 179 citations

Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

2000 • 178 citations

NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cells

2001 • 158 citations

SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity

1999 • 157 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo

2006 • 138 citations

MRL/Mp CD4+,CD25− T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: A novel defect of T cell regulation in systemic lupus erythematosus

2005 • 131 citations

Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling

2004 • 130 citations

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

2004 • 120 citations

TGF‐β1 production by CD4⁺CD25⁺ regulatory T cells is not essential for suppression of intestinal inflammation

2005 • 115 citations

High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell‐mediated suppression in vitro

2003 • 90 citations

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

2001 • 81 citations

Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-4

2000 • 53 citations

Bcr–Abl activates the AKT/FoxO3 signalling pathway to restrict transforming growth factor‐β‐mediated cytostatic signals

2005 • 28 citations

Inhibition of transforming growth factor-β/Smad signaling by phosphatidylinositol 3-kinase pathway

2006 • 10 citations

Protein tyrosine phosphatase 1B regulates TGFβ1-induced Smad2 activation through PI3 kinase-dependent pathway

2006 • 10 citations