Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

CD4 T cells: fates, functions, and faults

2008 • 1,618 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

2007 • 618 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo

2006 • 422 citations

Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling

2002 • 404 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

The main function of IL-2 is to promote the development of T regulatory cells

2003 • 323 citations

Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems

2006 • 321 citations

Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action

1999 • 306 citations

Emerging Challenges in Regulatory T Cell Function and Biology

2007 • 245 citations

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4⁺ and CD8⁺ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

1996 • 218 citations

CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production

2005 • 198 citations

Regulation of CD4⁺CD25⁺ regulatory T cell activity: it takes (IL‐)two to tango

2005 • 167 citations

Adenylyl cyclases: structure, regulation and function in an enzyme superfamily

1997 • 151 citations

Higher-order organization and regulation of adenylyl cyclases

2006 • 146 citations

TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling

2004 • 141 citations

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

1996 • 91 citations

3′,5′-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues

2005 • 73 citations

Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes

2006 • 59 citations

Mechanism of Prostaglandin (PG)E2-Induced Prolactin Expression in Human T Cells: Cooperation of Two PGE2 Receptor Subtypes, E-Prostanoid (EP) 3 and EP4, Via Calcium- and Cyclic Adenosine 5′-Monophosphate-Mediated Signaling Pathways

2004 • 45 citations

Expression of GAGE family proteins in malignant melanoma

2006 • 27 citations

Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression

2007 • 19 citations