Interaction of NF-κB and NFAT with the Interferon-γ Promoter

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

The ins and outs of Raf kinases

1994 • 537 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Estrogen regulates the IFN-gamma promoter.

1991 • 409 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.

1991 • 138 citations

Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).

1993 • 135 citations

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

1992 • 134 citations

Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

1995 • 130 citations

Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages.

1994 • 121 citations

NF-AT-AP-1 and Rel-bZIP: Hybrid vigor and binding under the influence

1994 • 118 citations

One-signal requirement for interferon-gamma production by human large granular lymphocytes.

1987 • 116 citations

Interferon-γ: Producer cells, activation stimuli, and molecular genetic regulation

1990 • 110 citations

Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line

1995 • 108 citations

Synthesis of Type 1 (IFNyγ) and Type 2 (IL‐4, IL‐5, and IL‐10) Cytokines by Human Eosinophils

1996 • 96 citations

Induced expression of mRNA for IL-5, IL-6, TNF-alpha, MIP-2 and IFN-gamma in immunologically activated rat peritoneal mast cells: inhibition by dexamethasone and cyclosporin A.

1995 • 95 citations

Differential Transcription Directed by Discrete Gamma Interferon Promoter Elements in Naive and Memory (Effector) CD4 T Cells and CD8 T Cells

1997 • 92 citations

A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence “cytokine-1”.

1992 • 90 citations

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

1992 • 87 citations

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

1992 • 83 citations

Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin.

1996 • 76 citations

Characterization of a silencer regulatory element in the human interferon-gamma promoter.

1994 • 62 citations

Interferon-γ: A Key Immunoregulatory Lymphokine

1993 • 62 citations

Identification of enhancer-like elements in human IFN-gamma genomic DNA.

1990 • 61 citations

IDENTIFICATION OF A CALCIUM-INDUCIBLE, CYCLOSPORINE-SENSITIVE ELEMENT IN THE IFN-?? PROMOTER THAT IS A POTENTIAL NFAT BINDING SITE1

1996 • 61 citations

Molecular dissection of the mouse interleukin-4 promoter.

1993 • 59 citations

The human interferon‐γ gene contains an inducible promoter that can be transactivated by tax I and II

1991 • 58 citations

Interleukin-12 Stimulates B Cell Growth by Inducing IFN-γ

1996 • 51 citations

A model of human cytokine regulation based on transfection of gamma interferon gene fragments directly into isolated peripheral blood T lymphocytes.

1990 • 44 citations

Epidermal Keratinocyte Production of Interferon-γ Immunoreactive Protein and mRNA Is an Early Event in Allergic Contact Dermatitis

1996 • 38 citations

Constitutive and inducible protein/DNA interactions of the interferon-γ promoter inin vivo CD45RA and CD45RO T helper subsets

1997 • 31 citations

Characterization of NF(P), the Nuclear Factor That Interacts with the Regulatory P Sequence (5′-CGAAAATTTCC-3′) of the Human Interleukin-4 Gene: Relationship to NF-κB and NF-AT

1994 • 20 citations

Regulation of cellular gene expression by interferon-gamma: Involvement of multiple pathways

1990 • 13 citations

IFN-Gamma Production from Human Th1 Cells Is Controlled by Raf Kinase

1997 • 6 citations