STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 • 1,238 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice

2001 • 486 citations

Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells

2006 • 482 citations

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

1998 • 426 citations

STAT3 Is Required for Flt3L-Dependent Dendritic Cell Differentiation

2003 • 328 citations

STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

2006 • 308 citations

Chromatin Remodeling of Interleukin-17 (IL-17)-IL-17F Cytokine Gene Locus during Inflammatory Helper T Cell Differentiation

2007 • 296 citations

Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes

2006 • 230 citations

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils

2006 • 187 citations

Cell fate decision: T-helper 1 and 2 subsets in immune responses.

2000 • 130 citations

Phospholipase Cγ2 Provides Survival Signals via Bcl2 and A1 in Different Subpopulations of B Cells

2003 • 39 citations

NABP1, a novel RORγ-regulated gene encoding a single-stranded nucleic-acid-binding protein

2006 • 29 citations